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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation and mechanical properties显示文摘 | Gomes M E Godinho J S Tchalamov D | 2002 | Materials Science and Engineering2002，，19： | 2 |
| 3 | Robust Stability of Uncertain Polytopic Linear Time-Delay Systems with Saturating Inputs: An LMI Approach显示文摘 | Tarbouriech S Garcia G Gomes J M | 2002 | Computers and Electrical Engineering2002，28，3： | 1 |
| 4 | A munn type representation for a class of E-semiadequate semigroups显示文摘 | FOUTAIN J GOMES M S G GOULD V | 1999 | Journal of Algebra1999，218，： | 1 |
| 5 | Estimation in vivo of the body and carcass chemical composition of growing lambs by real-time ultrasonography显示文摘 | SILVA S R GOMES M J MAS-DA-SILVA A | 2005 | Journal of Animal Science2005，83，： | 1 |
| 6 | Fundanmental Ehresmann semigroups显示文摘 | GOMES G M S GOULD V | 2001 | Semigroup Forum2001，63，： | 1 |
| 7 | Separation of biodiesel and glycerol using ceramic membranes显示文摘 | SERGI GOMES M C PEREIRA N C DAVANTEL DE BARROS S T | 2010 | JournalofMembraneScience2010，352，2： | 1 |
| 8 | Delay- dependent anti-windup strategy for linear systems with saturat- ing inputs and delayed outputs显示文摘 | Tarbouriech S Gomes Da Silva Jr J M Garcia G | 2004 | International Journal of Ro- bust and Nonlinear Control2004，14，7： | 1 |
| 9 | Fundamental Ehresmann semigroups显示文摘 | Gomes G M S V Gould | 2001 | Semigroup Forum2001，63，： | 1 |
| 10 | Laser action in strongly scattering media显示文摘 | Lawandy N M Balachandran R M Gomes A S L | 1994 | Nature1994，，368： | 1 |
| 11 | Daily supplementation with mushroom ( Agaricus bisporus ) improves balance and working memory in aged rats 显示文摘 | THANGTHAENG N MILLER M GOMES S M | 2015 | Nutrition Re- search2015，35，12： | 1 |
| 12 | On the ranks of certain finite semigroups of transformations显示文摘 | GOMES G M S HOWIE J M | 1987 | Math Proc Cambridge Phil Soc1987，101，3： | 1 |
| 13 | An amperometric biosensor for polyphenolic compounds in red wine 显示文摘 | Gomes S A S S Nogneim J M F Rebelo M J F | 2004 | Biosensors and Bioelectronies2004，20，6： | 1 |
| 14 | Numerical modeling of an industrial aluminum melting furnace显示文摘 | Nieckele A O Naccache M F Gomes M S P | 2004 | Journal of Energy Resources Technology2004，126，1： | 1 |
| 15 | On the ranks of certain semigroups of order-preserving transformations显示文摘 | GOMES G M S HOWIE J M | 1992 | Semigroup Forum1992，45，3： | 1 |
| 16 | Biofuels production and the environmental indicators显示文摘 | GOMES M S P MUYLAERT DE ARAUJO M S | 2009 | Renew Sustain Energy Rev2009，13，8： | 1 |
| 17 | Heat stress impairs performance and induces intestinal inflammation in broiler chickens infected with Salmonella Enteritidis显示文摘 | Quinteiro Filho W M Gomes A V S Pinheiro M L | 2012 | Avian Pa-thology2012，41，5： | 1 |
| 18 | On the ranks of certain sernigroups of order-preserving transformations显示文摘 | Gomes G M S HowieJ M | 1992 | Semigroup Forum1992，450，： | 1 |
| 19 | Decolorization of textile dyes by laccase from a newly isolated strain of Trametes modesta 显示文摘 | Nyanhongo G S Gomes J Gubitz G M | 2002 | Water Research2002，36，6： | 1 |
| 20 | Degradation of 3-chlorobenzoate under low- oxygen conditions in pure and mixed cultures of the anoxygenic photoheterotroph Rhodopseudomonas palustris DCP3 and an aerobic aerobic Alcaligenes species 显示文摘 | KROONEMAN J VANDER AKKER S GOMES T M P | 1999 | Appl Environ Microbiol1999，65，1： | 1 |
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