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| 1 | GRADE指南:Ⅵ.证据质量评价--不精确性(随机误差)显示文摘GRADE建议通过检查95%可信区间(CI)为决定不精确性的最佳方法。在指南实际运用中,如果CI的上、下限值代表了真实效应,而临床实际情况与之不符时,必须降低证据质量级别(即对效应估计值的把握度)。除外当效应值很大且可信区间提示效应稳健,而总样本量不大且事件数很少的情况,其他应考虑因不精确性而降低证据质量级别。作此决定时,可计算有足够检验效能的单个试验所需的病例数(定义为'最优信息样本量',即optimal information size,OIS)。对连续型变量,我们建议用类似方法,首先考虑可信区间上、下限值,再计算OIS。系统评价(SR)所需方法略有不同。如果95%CI不包括相对危险度(RR)为1,且总事件发生数或病例数超过OIS标准,则精确性良好。如果95%CI包括了明显获益或危害(我们建议以RR值<0.75或>1.25作粗标准),即使达到OIS要求,因不精确性而降低证据质量级别较恰当。 | Gordon Guyatt Andrew D.Oxman Regina Kunz Jan Brozek Pablo Alonso-Coello David Rind PJ Devereaux Victor M.Montori Bo Freyschuss Gunn Vist Roman Jaeschke John W.Williams Jr. Mohammad Hassan Murad David Sinclairk Yngve Falck-Ytter Joerg Meerpohl Craig Whittington Kristian orlund Je Andrews Holger J.Schünemann 代表GRADE工作组 李幼平 王莉 陈尹 高霑 | 2011 | 中国循证医学杂志2011，11，12： | 43 |
| 2 | 血管紧张素Ⅱ诱导的高血压所引起的T淋巴细胞活化与血管炎症的中枢和外周机制显示文摘研究者先前就发现,T淋巴细胞对血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)诱导的高血压的发生发展是必需的,但是,高血压发生过程中的T细胞活化机制尚不明确。该文研究者探讨了中枢神经系统和血压升高在AngⅡ导致的T细胞活化与血管炎症中的作用。 | 张玲玉 叶鹏 Marvar PJ Thabet SR Guzik TJ Lob HE McCann LA Weyand C Gordon FJ Harrison DG | 2010 | 中华高血压杂志2010，18，12： | 15 |
| 3 | 循证实践中的医患选择——医疗决策不能迷信证据而要靠人显示文摘 | R Brain Haynes PJ Devereaux Gordon H Guyatt 陈霖 | 2003 | 中国循证医学杂志2003，3，4： | 7 |
| 4 | Factors affecting saphenous vein graft patency: clinical and angiographic study in 1402 symptomatic pa- tients operated on between 1977 and 1999 显示文摘 | Shah PJ Gordon I Fuller J | 2003 | J Thorac Cardiovase Surg2003，126，6： | 1 |
| 5 | Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit caccine candidates by comparative genomics显示文摘 | PJ Cockle SV Gordon A Lalvani | | 0，，： | 1 |
| 6 | QIIME allows analysis of high-throughput community sequencing data 显示文摘 | Caporaso JG Kuczynski J Stombaugh J Bittinger K Bushman FD Costello EK Fierer N Pena AG Goodrich JK Gordon JI Huttley GA Kelley ST Knights D Koenig JE Ley RE Lozupone CA Mcdonald D Muegge BD Pirrung M Reeder J Sevinsky JR Tumbaugh PJ Walters WA Widmann J Yatsunenko T Zaneveld J Knight R | 2010 | Nat Methods2010，7，5： | 1 |
| 7 | Prevalence of picky eatersamong infants and toddlers and their caregivers' decisinns abotlt ofh*ring a new food显示文摘 | Carruth BR Ziegler PJ Gordon A | 2004 | J Am Diet Assoc2004，，： | 1 |
| 8 | The core gut microbiome,energy balance and obesity显示文摘 | Turnbaugh PJ Gordon JI | | 0，，： | 1 |
| 9 | Reproducibility of left ventricular volume by two-dimensional echocardiography显示文摘 | Gordon EP Schnittger I Fitzgerald PJ | 1983 | J Am Coll Cardiol1983，2，： | 1 |
| 10 | Role of vagal afferetns in the mediation of chlorpyr ifos-induced fever in the rat显示文摘 | Rowsey PJ | 2000 | Journal of Thermal Biology2000，25，12： | 1 |
| 11 | Phototesting prior to narrowband (TL-01) ultraviolet B phototherapy显示文摘 | Gordon PM Saunders PJ Diffey BL | 1998 | Br J Dermatol1998，139，5： | 1 |
| 12 | Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics显示文摘 | Cockle PJ Gordon SV Lalvani A | 2002 | Infect Immun2002，70，12： | 1 |
| 13 | Factors affecting saphenous vein graft patency:clinical and angiographic study in 1 402 symptom- atic patients operated on between 1977 and 1999显示文摘 | Shah PJ Gordon I Fuller J | 2003 | J Thorac Cardiovasc Surg2003，126，6： | 1 |
| 14 | Thermoregulation and its influence on toxicity assessment 显示文摘 | Gordon C J Spencer PJ Hotchkiss J | 2008 | Toxicology2008，244，23： | 1 |
| 15 | Computerized quantitative analysis of left ventricular wall motion by two-dimensional echocardiography显示文摘 | Schnittger I Fitzgerald PJ Gordon EP | 1984 | Circulation1984，70，： | 1 |
| 16 | Factors affeeting saphenous vein graft patency:clinical and angiographie study in 1402 symptomatic patients operated on between 1977and 1999显示文摘 | Gordon I Fuller J | 2003 | J Thorac Cardiovasc Surg2003，126，6： | 1 |
| 17 | Factors affecting saphenous vein graft patency: clinical and angiographic study in 1 402 symptomatic patients operated on between 1977 and 1999 显示文摘 | Shah PJ Gordon I Fuller J | 2003 | J Thorac Cardiovasc Surg2003，126，6： | 1 |
| 18 | Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics显示文摘 | Cockle PJ Gordon SV Lalvani A | 2002 | Infect Immun2002，70，12： | 1 |
| 19 | Field evaluation of a novel differential diagnostic reagent for detection of Mycobacterium bovis in cattle显示文摘 | Cockle PJ Gordon SV Hewinson RG Vordermeier HM | 2003 | Comp Med2003，53，6： | 1 |
| 20 | Factors affecting saphenous vein graft patency: clinical and angiographic study in 1402 symptomatic patients operated on between 1977 and 1999显示文摘 | Shah PJ Gordon I Fuller J | 2003 | J Thorac Cardiovasc Surg2003，126，6： | 1 |
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