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| 1 | Prognostically relevant gene signatures of high-grade serous ovarian carcinoma显示文摘 | Verhaak Roel G W Tamayo Pablo Yang Ji-Yeon Hubbard Diana Zhang Hailei Creighton Chad J Fereday Sian Lawrence Michael Carter Scott L Mermel Craig H Kostic Aleksandar D Etemadmoghadam Dariush Saksena Gordon Cibulskis Kristian Duraisamy Sekhar | 2013 | Journal of Clinical Investigation2013，，1： | 2 |
| 2 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 3 | Liquid chromatographic determination of Fumonisins B1,B2, and B3 in foods and feeds显示文摘 | Eric W Sydenham Gordon S Shephard Pieter G Thiel | 1992 | Mycotoxins1992，75，： | 1 |
| 4 | The quantity and quality of physiealaetivity among those trying to lose weight 显示文摘 | Gordon P M Heath G W Holmes A | 2000 | American Journal of Preventive Medicine2000，18，1： | 1 |
| 5 | Genetic transformation of mouse embryos by microinjection of purified DNA显示文摘 | Gordon J W Seangos G A Diane J | 1980 | Proc Natl Acad Sci USA1980，77，： | 1 |
| 6 | Quantitative fluorescence resonance energy transfer measurements using fluroescnece miscroscop显示文摘 | Gordon G W Berry G Liang X H Levine B Herman B | | 0，，： | 1 |
| 7 | When bad things happen to good trees显示文摘 | AIVALIOTIS M GORDON G GRAVEMAN W | 2001 | Graph Theory2001，37，： | 1 |
| 8 | Temporal analysis of hepatocyte differentiation by small hepatocyte-like progenitor cells during liver regeneration in retrorsine-exposed rats显示文摘 | Gordon G Coleman W Grisham J | 2000 | Am J Pathol2000，157，： | 1 |
| 9 | The use of aer- ation to enhance ammonia nitrogen removal in constructed wetlands 显示文摘 | Jamieson T S Stratton G W Gordon R | 2003 | Canadian Biosystems Engineering2003，，45： | 1 |
| 10 | Genetic transformation of mouse embryos by microinjection of purified DNA显示文摘 | Gordon J W Scangos G A Plotkin D J | 1980 | Proc Natl Acad Sci USA1980，77，： | 1 |
| 11 | Genetic transformation of mouse embryos by microinjection of purified DNA显示文摘 | Gordon J W Scangos G A Plotkin D J | 1980 | Proc Natl Aead Sci USA1980，77，12： | 1 |
| 12 | Cryptogenic cirrhosis: elinicopathologic findings at and after liver transplantation显示文摘 | AYTA G GORDON F D LEWIS W D | 2002 | Hum Pathol2002，33，11： | 1 |
| 13 | Differential global geneexpression in red and white skeletal muscle显示文摘 | Campell W G Gordon S E Carlson C J | 2001 | Am J Physiol Cell Physiol(C)2001，280，： | 1 |
| 14 | Genetic transformationof mouseembryos by microinjection of purified DNA显示文摘 | Gordon J W Scangos G A Plotkin D J | 1980 | Proceedings of the National Academy of Sciences1980，77，12： | 1 |
| 15 | An abinitio study of potentialenergy surfaces for N8 isomers显示文摘 | Chung G S Schimidt M W Gordon M S | 2000 | J Phys Chem A2000，104，： | 1 |
| 16 | Investigation into the mechanisms of flame retardation on wool显示文摘 | GORDON P G MCMAHON D T W STEPHENS L J | 1977 | Text Res J1977，47，11： | 1 |
| 17 | Composition and size distributions of particles released in refuse incineration显示文摘 | Greenberg R R Zoller W H Gordon G E | 1978 | Environ Sci Technol1978，12，5： | 1 |
| 18 | Efficacy and safety of galantamine in patients with mild to moderate Alzheimer's disease:multicentre randomised controlled trail显示文摘 | GORDON K W SEAN L ELS G | 2000 | BMJ2000，321，： | 1 |
| 19 | Genetic transfor- mation of mouse embryos by mieroiniection 显示文摘 | Gordon J W Scangos G A Plotkin D J | 1980 | Proe Natl Acad Sci USA1980，77，： | 1 |
| 20 | Docosahexaenoic acid signalolipidomics in nutrition:significance in aging,neuroinflammation,macular degeneration,Alzheimer's,and other neurodegenerative diseases显示文摘 | Bazan N G Molina M F Gordon W C | 2011 | Annu Rev Nutr2011，31，： | 1 |
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