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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non- small cell lung cancer显示文摘 | Greco F A Bonomi P Crawford J | 2008 | Lung Cancer2008，61，1： | 1 |
| 3 | Late,but not early,paternal effect on human embryo development is related to sperm DNA fragmentation显示文摘 | Tesarik J Greco E Mendoza C | 2004 | Hum Reprod2004，19，3： | 1 |
| 4 | Oxidized-LDL/beta(2)- glycoprotein I complexes are associa- ted with disease severity and increased risk for adverse out- comes in patients with acute coronary syndromes显示文摘 | GRECO T P CONTI-KELLY A M ANTHONY J R | 2010 | Am J Clin Pathol2010，133，5： | 1 |
| 5 | Corrosion of iron in an H2 S - CO2 - H20 system: Corrosion filrm properties on pure iron 显示文摘 | ASardisco J B Wright W B Greco E C | 1963 | Corrosion1963，19，10： | 1 |
| 6 | Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells 显示文摘 | Steven J Greco Sraboni Sarkar Jane M Johnston | 2008 | Biochemical and Biophysical Research Communications2008，376，3： | 1 |
| 7 | Paternal effects acting during the first cell cycle of human preimplantation development after ICSI显示文摘 | Tesarik J Mendoza C Greco E | 2002 | Hum Reprod2002，17，1： | 1 |
| 8 | Multi - criteria classifica- tion--a new scheme for application of dominance - basec deci- sion rules显示文摘 | Blaszczynski J Greco S Slowinski R | 2007 | European Journal of Operational Research2007，181，3： | 1 |
| 9 | RE-l-silen- cing transcription factor shows tumor-suppressor func- tions and negatively regulates the oncogenic TAC1 in breast cancer cells 显示文摘 | Reddy B Y Greco S J Patel P S | 2009 | Proc Natl Acad Sci U S A2009，106，11： | 1 |
| 10 | Coherent radar targetdetection in heavy-tailed compound-Gaussian clutter 显示文摘 | Sangston K J Gini Fulvio Greco M S | 2012 | IEEETransactions on Aerospace and Electronic Systems2012，48，1： | 1 |
| 11 | Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non- small cell lung cancer显示文摘 | Greco FA Bonomi P Crawford J | 2008 | Lung Cancer2008，61，1： | 1 |
| 12 | Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells显示文摘 | Greco S J Sarkar S Johnston J M | 2009 | Biochemical and Biophysical Research Communications2009，380，1： | 1 |
| 13 | The SMAA-PROMETHEE methods显示文摘 | CORRENTE S FIGUEIRA J R GRECO S | 2014 | European Journal of Operational Research2014，239，2： | 1 |
| 14 | Transpositional behaviour of an Ac/Ds system for revere genetics in rice显示文摘 | Ouwerkerk P B De Kam R J | 2003 | Theor Appl Genet2003，108，1： | 1 |
| 15 | Effect of lesions of the ventrolateral preoptic nucleus on NREM and REM sleep显示文摘 | Lu J Greco MA Shiromani P | 2000 | J Neurosci2000，20，： | 1 |
| 16 | Continuum damage-healing mechanics with application to self-healing composite显示文摘 | Barbero E J Greco F Lonetti P | 2005 | International Journal of Damage Mechanics2005，14，1： | 1 |
| 17 | Differentiation of spermatogenic cells during in-vitro culture of testicular biopsy samples from patients with obstructive azoospermia:effect of recombinant follicle stimulating hormone显示文摘 | Tesarik J Greco E Rienzi L | 1998 | Hum Reprod1998，13，： | 1 |
| 18 | Robust ranking of multi-criteria alternatives using value functions compatible with holistic preference information 显示文摘 | SLOWINSKI R GRECO S FIGUEIRA J R | 2008 | Journal of Chongqing University of Posts and Telecommunications( Natural Science Edition)2008，20，3： | 1 |
| 19 | Interaction between the GROWTH-REGULATING FACTOR and KNOTTED1-LIKE HOMEOBOX Families of Transcription Factors 显示文摘 | Kuijt S J H Greco R Agalou A | 2014 | Plant Physiology2014，164，4： | 1 |
| 20 | Laparoscopic adrenalectomy in urological centres-the experience of the German Laparoscopic Working Group显示文摘 | Greco F Hoda M R Rassweiler J | 2011 | BJU Int2011，108，10： | 1 |
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