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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | On secret sharing systems显示文摘 | Greene J W Hellman M E | 1983 | IEEE Transactions on Information Thcory1983，29，1： | 1 |
| 3 | Identification of novel Smad binding proteins 显示文摘 | Warner D R Roberts E A Greene R M | 2003 | Biochem Biophys Res Commun2003，312，4： | 1 |
| 4 | The ratio of ELR_ to ELR- CXC chemokines affects the lung and liver injury following hepatic ischemia/reperfusion in the rat 显示文摘 | Colletti L M Green M E Burdick M D | 2000 | Hepatology2000，31，： | 1 |
| 5 | Concurrent and predictive validity of a self-reported measure of medication adherence显示文摘 | MORISKY D E GREEN L W LEVINE D M | 1986 | Med Care1986，24，1： | 1 |
| 6 | Seed mass and early survivorship of tree species in upland clearings and shelterwoods显示文摘 | GREENE D F JOHNSON E A | 1998 | Canadian Journal of Forest Research1998，28，： | 1 |
| 7 | Coneurrent and pre-dictive va-lidity of aself-reported measure of medieation ad-herenee显示文摘 | MORLSKY D E GREEN L W LEVINE D M | 1986 | MedCare1986，24，1： | 1 |
| 8 | Foliar morphology and canopy nitrogen as predictors of lightuse efficiency in terrestrial vegetation显示文摘 | Green D S Erickson J E Kruger E L | 2003 | Agricultural and Forest Meteorology2003，115，： | 1 |
| 9 | Referendum contingent valuation anchoring and willingness to pay for poblic goods显示文摘 | GREEN D JACOWITZ K E KAHNEMAN D | 1998 | Resources and Energy Economic1998，20，： | 1 |
| 10 | Open systems: panoramic views of gene expression 显示文摘 | Green C D Simons J F Taillon B E | 2001 | Journal of Immunological Methods2001，250，12： | 1 |
| 11 | Microstructure and oxidation-resistance of Til-xy-zAlxCryYzN layers grown by combined steered-arc/ unbalanced-magnetron-sputter deposition显示文摘 | DONOHUE L A SMITH I J MNNZ W D PETROV I GREENE J E | 1997 | Surface and Coatings Technology1997，9495，： | 1 |
| 12 | Discrimination of Aspergillus isolates at the species and strain level by matrix-assisted laser desorption/i- onization time-of-flight mass spectrometry fingerprinting 显示文摘 | Hettick J M Green B J Buskirk A D Kashon M L Slaven J E Janotka E | 2008 | Analytical biochemistry2008，380，2： | 1 |
| 13 | Devonian matrix dolomites and deep burial carbonate cements:a comparison between the Rimbey-Meadowbrook reef trend and the deep basin of west-central Alberta显示文摘 | Mountjoy E W Green D G Machel H G | 1999 | Bulletin of Canadian Petroleum Geology1999，47，： | 1 |
| 14 | Laparoscopic colectomy for cancer is not inferior to open surgery based on 3-year data from the COST Study Group trial显示文摘 | Fleshman J Sargent D J Green E | 2007 | Ann Surg2007，246，4： | 1 |
| 15 | A new continuum-source atomic ab-sorption spectrometer显示文摘 | WILLIAMS D T GREEN A E S | 1994 | Review of Scientific Instruments1994，65，11： | 1 |
| 16 | British Society of Gastroenterology 显示文摘 | Williams E Green J Beckingham I Parks R Martin D Lombard M | 2013 | Guidelines on the manage- ment of common bile duct stones (CBDS)2013，57，7： | 1 |
| 17 | On Sharing Secret Systems显示文摘 | Karnin E D Greene J W Hellman M E | 1983 | IEEE Transactions on Information Theory1983，29，1： | 1 |
| 18 | Concurrent and predic' tive validity of a self-reported measure of medication adherence显示文摘 | Morisky D E Green L w Levine D M | 1986 | Med Care1986，24，1： | 1 |
| 19 | Laparoscopic colectomy for cancer is not inferior to open surgery based on 5-year data from the COST Study Group trial显示文摘 | Fleshman J Sargent D J Green E | 2007 | Ann Surg2007，246，4： | 1 |
| 20 | Fracture behavior of low density fibrous ceramics显示文摘 | GREEN D J RITTER J E LANGE F F | 1982 | J Am Ceram Soc1982，65，3： | 1 |
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