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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Apoptosis after intestinal ischemia-reperfusion injury显示文摘 | Shah K A Shndra S Green C J | 1997 | Transplantation1997，64，10： | 3 |
| 3 | DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice显示文摘 | Meira Lisiane B Bugni James M Green Stephanie L Lee Chung-Wei Pang Bo Borenshtein Diana Rickman Barry H Rogers Arlin B Moroski-Erkul Catherine A McFaline Jose L Schauer David B Dedon Peter C Fox James G Samson Leona D | 2008 | Journal of Clinical Investigation2008，，7： | 2 |
| 4 | Comparative DNA sequence analysis of wheat and rice genomes显示文摘 | La Rota M Bermudez-Kandianis C E Greene R A Kantety R | 2003 | Genome Res2003，13，： | 1 |
| 5 | Use of ozone in the food industry显示文摘 | Zeynep B Guzel-Seydim Annel K Greene A C Seydim | 2004 | Lebensm-Wissu-Technol2004，37，： | 1 |
| 6 | Vitamin C degradation in plant cells via enzymatic hydrolysis of 4-0 oxalyl-L threonate显示文摘 | GREEN M A FRY S C | 2005 | Nature2005，433，： | 1 |
| 7 | Wound-induced proteinase inhibitor in plant leaves:a possible defense mechanism against insects显示文摘 | GREEN T R RYAN C A | 1972 | Science1972，175，： | 1 |
| 8 | Use of ozone in the food industry显示文摘 | Zeynep B Guzel-Seydim Annel K Greene A C Seydim | 2004 | Lebensm -Wiss u -Technol2004，37，： | 1 |
| 9 | Buried contact silicon solar cells显示文摘 | Wenham S R Honsberg C R Green M A | 1994 | Solar Energy Matrials and Solar Cells1994，34，： | 1 |
| 10 | Shape - controlled synthesis of colloidal platinum nanoparticles 显示文摘 | T S Ahmadi Z L Wang T C Green A Henglein M A El- Sayed | 1996 | Science1996，272，： | 1 |
| 11 | Fuel Consumption Minimization of a Microgrid 显示文摘 | Carlos A Hernandez-Arambur Tim C Green Nicolas Mugniot | 2005 | IEEE Transactions on Industry Applications2005，41，3： | 1 |
| 12 | Response and modeling of cantilever retaining walls subjected to seismic motions显示文摘 | GREEN R A OLGUN C G CAMERON W I | 2008 | Computer-Aided Civil and Infrastructure Engineering2008，23，4： | 1 |
| 13 | The Tobacco Chemists' Research Conference: a half century forum for advances in analytical methodology of tobacco and its products显示文摘 | GREEN C R RODGMAN A | 1996 | Recent Advances in Tobacco Science1996，22，13： | 1 |
| 14 | Electron energy distributions in e- beam generated Xe and Ar plasmas 显示文摘 | Elliott C J Greene A E | 1976 | Journal of Applied Physics1976，47，7： | 1 |
| 15 | A single institution review of new breast malignancies identified solely by sonography显示文摘 | Greene T Cocilovo C Estabrook A | 2006 | J Am Coll Surg2006，203，6： | 1 |
| 16 | Does entrepreneurial self- efficacy distinguish entrepreneurs from managers 显示文摘 | Chen C C Greene P G Crick A | 1998 | Journal of Business Venturing1998，，13： | 1 |
| 17 | Deve- lopment and validation of the Infertility Self-Efficacy Scale显示文摘 | Cousineau T M Green T C Corsini E A | 2006 | Fertil Steril2006，85，6： | 1 |
| 18 | Does entrepreneurial self-efficacy distinguish entrepreneur from managers显示文摘 | Chen C Greene P Crick A | | 0，，13： | 1 |
| 19 | Laboratory investigation of a passive acoustic method for measurenlent of underwater gas seep ebullition显示文摘 | GREENE C A WILSON P S | 2012 | The Journal of Ihe Acoustical So-ciety of America2012，131，1： | 1 |
| 20 | Using a GIS-based Network Analysis to Determine Urban Greenspace Accessibility for Different Ethnic and Religious Groups显示文摘 | Comber A Brunsdon C Green E | 2008 | Landscape and Urban Planning2008，86，1： | 1 |
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