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| 1 | Morphological properties and residual strain along the small intestine in rats显示文摘瞄准:剩余应力和紧张为胃肠的功能是重要的并且联系到几何配置,装载条件和胃肠的道的零压力的状态。这个工程的目的是提供 morphometric 数据,剩余为老鼠拉紧小肠(n =11 ) 。方法:走近以资产净值出售的州,肠通过手术被切除,转了到机关洗澡并且横着切了进短圆形的片断。每枚戒指为获得零压力的状态放射状地被切。剩余压力能被一个开的角度描述。零压力的状态和以资产净值出售的状态之间的紧张差别被称为剩余紧张。结果:大 morphometric 变化沿着小肠被发现。墙厚度在近似十二指肠是最高的并且沿着小肠(P<0.001 ) 的轴在远侧的方向减少了。内部、外部的表面的环绕的长度由 30-50%(P<0.001 ) 沿着十二指肠的长度很快减少了。墙区域和腔区域显示出一个类似的模式(P<0.001 ) 。处于零压力的状态,戒指总是在做切割以后开口了。当时,实验导致了更大的内部环绕的长度和更小的外部环绕的长度与以资产净值出售的状态相比。墙厚度和墙区域没在以资产净值出售、零压力的状态之间不同。沿着十二指肠的长度增加并且有它的最高的价值的开的角度和正切旋转角度 30% 击倒肠。进一步,在肠下面,它再减少了(P<0.001 ) 。serosal 剩余紧张近与最高的价值是张力的到 Treitz (P<0.001 ) 的系带。mucosal 剩余紧张近在有在 -0.25 和 -0.4 之间的平均价值并且与最低价值的小肠的所有片断是压缩的到 Treitz (P<0.001 ) 的系带。结论:在 morphometric 性质和剩余紧张的轴的变化在小肠被发现。大剩余紧张的存在显示零压力的状态必须在胃肠的道在未来简历被认为机械研究。 | Hans Gregersen | 2002 | World Journal of Gastroenterology2002，8，2： | 3 |
| 2 | Relationships of CDXs and apical sodium-dependent bile acid transporter in Barrett's esophagus显示文摘Barrett's esophagus (BE) is characterized by intestinal metaplasia with the differentiated epithelium replaced by another type of epithelium morphologically similar to normal intestinal epithelium. The metaplasia is preceded by bile and acid reflux into the esophagus. BE is a premalignant condition associated with increased risk of esophageal cancer, especially esophageal adenocarcinoma. The Caudal-related homeodomain transcription factors Caudal-related homeodomain transcription factor CDX1 and CDX2 are expressed exclusively in the small and large intestine, playing important roles in proliferation and differentiation of intestinal epithelial cells. Ectopic expression of CDX1 and CDX2 occurs in BE. The apical sodium-dependent bile acid transporter (ASBT) is expressed primarily in terminal ileum where it is a key factor for intestinal reabsorption of bile salts. In addition to upregulation of CDX1 and CDX2, ASBT expression is up-regulated in BE. Furthermore, both CDX1/CDX2 and ASBT expressions are down-regulated in high-grade esophageal dysplasia. The alteration of the above-mentioned factors calls for attention: what is the relationship between CDXs and ASBT aberrant expression in BE? In this commentary, we discuss this issue on basis of the recent study done by Ma et al . | Jingbo Zhao Hans Gregersen | 2013 | World Journal of Gastroenterology2013，19，18： | 3 |
| 3 | Biomechanics of the Gastrointestinal Tract New Perspectives in Motility Research and Diagnostics显示文摘本书提出了胃肠动力学和诊断学的新观点。 | Gregersen,Hans 柯美云 | 2005 | 国外医学情报2005，26，4： | 2 |
| 4 | Morpho-mechanical intestinal remodeling in type 2 diabetic GK rats — Is it related to advanced glycation end product formation?显示文摘 | Jingbo Zhao Pengmin Chen Hans Gregersen | 2013 | Journal of Biomechanics2013，，： | 1 |
| 5 | Phasic and Tonic Stress–Strain Data Obtained in Intact Intestinal Segment In Vitro显示文摘 | Jingbo Zhao Donghua Liao Hans Gregersen | 2008 | Digestive Diseases and Sciences2008，，12： | 1 |
| 6 | Biomechanical and histomorphometric esophageal remodeling in type 2 diabetic GK rats显示文摘 | Jingbo Zhao Donghua Liao Hans Gregersen | 2007 | Journal of Diabetes and Its Complications2007，，1： | 1 |
| 7 | Three-dimensional geometry analysis of the stomach in type II diabetic GK rats显示文摘 | Donghua Liao Jingbo Zhao Hans Gregersen | 2005 | Diabetes Research and Clinical Practice2005，，1： | 1 |
| 8 | Histomorphometry and Strain Distribution in Pig Duodenum with Reference to Zero-Stress State显示文摘 | Chunwen Gao Jingbo Zhao Hans Gregersen | 2000 | Digestive Diseases and Sciences2000，，8： | 1 |
| 9 | 不同疾病动物模型中的胃肠生物力学和组织结构重构显示文摘胃肠生物力学特性对其生理功能至关重要。在不同的病理情况下,胃肠生物力学特性和其组织结构会发生不同程度的重构,因此,用各种不同动物模型研究不同状态和不同疾病情况下GI的生物力学和组织形态重构是非常重要的。在过去十几年间,我们中心采用以种动物模型,如糖尿病模型、肠梗阻模型、饥饿模型、肠切除模型等,对不同状态下胃肠生物力学特性和其组织结构的重构进行了一系列研究。本文对与胃肠道有关的10种不同动物模型的胃肠道的零应力状态,残余应变,应力-应变和管壁组织结构的重构现象进行简单的综述。 | 赵静波 Hans Gregersen | 2008 | 医学综述2008，14，23： | 1 |
| 10 | Novel Multimodal Evaluation Technology for Symptom Characterization in GI Functional Diseases and Pharmacological Testing of Drugs显示文摘 | Hans Gregersen Asbjorn Mohr Drewes | 2014 | Journal of Pharmacy and Pharmacology2014，2，4： | 0 |
| 11 | New perspectives of studying gastrointestinal muscle function显示文摘胃肠道的运动机能首先用测压法和 X 光线照相术被学习了,尽管更多的间接试验也被使用了。当罐头在肌肉脱衣在试管内从肌肉性质的研究被估计,测压法和 X 光线照相术不关于肌肉性质提供详细信息。在最近的年里,基于阻抗 planimetric,一只扩张袋子里的压力代表性的区域关系的测量证明了提供更多的一种技术关于肌肉功能在活体内详细说明了信息。这评论显示出象长度紧张图,力量速度曲线和 preload-afterload 图那样的新肌肉功能分析的例子。 | Hans Gregersen Donghua Liao | 2006 | World Journal of Gastroenterology2006，12，18： | 0 |
| 12 | Multimodal pain stimulation of the gastrointestinal tract显示文摘疼痛和另外的感觉症状的理解和描述在在有胃肠的混乱的病人的诊断和评价的最重要的问题之中。唤起并且估计试验性的疼痛的方法最近为多模式的刺激与可能性发展成一个新区域(例如,电、机械、热、化学的刺激) 不同神经和疼痛,在人的小径毁坏。如此的方法模仿在诊所经验丰富的疼痛到高度。多模式的疼痛方法处于健康和疾病在内脏增加了我们不同外部受体的基本理解。和先进肌肉分析,方法增加了我们对敏感的受体的理解机械,在疾病的化学药品和温度刺激,例如全身的硬化和糖尿病。方法能也被用来解开中枢性痛机制例如涉及 allodynia 的那些,痛觉过敏和提交的疼痛。在中枢性痛机制的畸形经常依靠刺激可以帮助在这些病人理解症状的多模式的疼痛的长期的内脏疼痛和因此方法地在病人被看见。性差别在内脏的几疾病被观察了,并且在中枢性痛在男性和女性之间处理的差别用多模式的疼痛刺激被假设了。最后,多模式的方法最近被用来在官方补给的道对疼痛获得更多的卓见进药的效果。因此,多模式的方法无疑表示一个学生与内脏的各种各样的疾病在未来描述和病人的治疗向前走。 | Asbjφrn Mohr Drewes Hans Gregersen | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 13 | Advanced glycation end-product expression is upregulated in the gastrointestinal tract of type 2 diabetic rats显示文摘AIM:To investigate changes in advanced glycation end products(AGEs) and their receptor(RAGE) expression in the gastrointestinal(GI) tract in type 2 diabetic rats.METHODS:Eight inherited type 2 diabetic rats GotoKakizak(GK) and ten age-matched normal rats were used in the study.From 18 wk of age,the body weight and blood glucose were measured every week and 2 wk respectively.When the rats reached 32 wk,twocentimeter segments of esophagus,duodenum,jejunum,ileum,and colon were excised and the wet weight was measured.The segments were fixed in 10% formalin,embedded in paraffin and five micron sections were cut.The layer thickness was measured in Hematoxylin and Eosin-stained slides.AGE [N epsilon-(carboxymethyl) lysine and N epsilon-(carboxyethyl)lysine] and RAGE were detected by immunohistochemistry staining and image analysis was done using Sigmascan Pro 4.0 image analysis software.RESULTS:The blood glucose concentration(mmol/L) at 18 wk age was highest in the GK group(8.88 ± 1.87 vs 6.90 ± 0.43,P < 0.001),a difference that continued to exist until the end of the experiment.The wet weight per unit length(mg/cm) increased in esophagus,jejunum and colon from the normal to the GK group(60.64 ± 9.96 vs 68.56 ± 11.69,P < 0.05 for esophagus; 87.01 ± 9.35 vs 105.29 ± 15.45,P < 0.01 for jejunum; 91.37 ± 7.25 vs 97.28 ± 10.90,P < 0.05 for colon).Histologically,the layer thickness of the GItract was higher for esophagus,jejunum and colon in the GK group [full thickness(μm):575.37 ± 69.22 vs 753.20 ± 150.41,P < 0.01 for esophagus; 813.51 ± 44.44 vs 884.81 ± 45.31,P < 0.05 for jejunum; 467.12 ± 65.92 vs 572.26 ± 93.60,P < 0.05 for colon].In esophagus,the AGE and RAGE mainly distributed in striated muscle cells and squamous epithelial cells.The AGE distribution was much stronger in the GK group compared to the normal group both in the striated muscle layer and mucosa layer(immuno-positive area/ total measuring area %:4.52 ± 0.89 vs 10.96 ± 1.34,P < 0.01 for muscle; 8.90 ± 2.62 vs 22.45 ± 1.26,P < 0.01 for mucosa).No visible difference was found for RAGE distribution between the two groups.In the intestine AGE and RAGE distributed in epithelial cells of villi and crypt.RAGE was also found in neurons in the myenteric and submucosal plexus.The intensity of AGE staining in mucosa of all segments and RAGE staining in neurons in all segments were strongest in the diabetes group.Significant difference for AGE was found in the epithelial cells of villi and crypt in duodenum(immunopositive area/total measuring area %:13.37 ± 3.51 vs 37.48 ± 8.43,P < 0.05 for villi; 0.38 ± 0.12 vs 1.87 ± 0.53,P < 0.05 for crypt) and for RAGE in neurons of all segments(e.g.,for jejunum:no staining neurons% 0 vs 0,mild 36.0 ± 5.2 vs 28.7 ± 3.5,moderate 53.2 ± 4.8 vs 55.8 ± 5.4,strong 10.7 ± 1.1 vs 15.4 ± 2.0,P < 0.05).In the colon,RAGE was primarily found in neurons in the myenteric and submucosal plexus.It was stronger in the diabetes group than in the normal group(no staining neurons% 6.2 ± 0.2 vs 0.3 ± 0.04,mild 14.9 ± 2.1 vs 17.6 ± 1.5,moderate 53.1 ± 4.6 vs 44.7 ± 4.4,strong 25.6 ± 18 vs 43.6 ± 4.0,P < 0.05).In the rectum,RAGE was primarily found in the mucosa epithelial cells.CONCLUSION:The AGE and RAGE expression was upregulated in the GI tract of GK diabetic rats and may contribute to GI dysfunction in type 2 diabetic patients. | Peng-Min Chen Hans Gregersen Jing-Bo Zhao | 2015 | World Journal of Diabetes2015，6，4： | 4 |
| 14 | Gastrointestinal tract modelling in health and disease显示文摘The gastrointestinal (GI) tract is the system of organs within multi-cellular animals that takes in food, digests it to extract energy and nutrients, and expels the remaining waste. The various patterns of GI tract function are generated by the integrated behaviour of multiple tissues and cell types. A thorough study of the GI tract requires understanding of the interactions between cells, tissues and gastrointestinal organs in health and disease. This depends on knowledge, not only of numerous cellular ionic current mechanisms and signal transduction pathways, but also of large scale GI tissue structures and the special distribution of the nervous network. A unique way of coping with this explosion in complexity is mathematical and computational modelling; providing a computational framework for the multilevel modelling and simulation of the human gastrointestinal anatomy and physiology. The aim of this review is to describe the current status of biomechanical modelling work of the GI tract in humans and animals, which can be further used to integrate the physiological, anatomical and medical knowledge of the GI system. Such modelling will aid research and ensure that medical professionals benefit, through the provision of relevant and precise information about the patient's condition and GI remodelling in animal disease models. It will also improve the accuracy and efficiency of medical procedures, which could result in reduced cost for diagnosis and treatment. | Dong-Hua Liao Jing-Bo Zhao Hans Gregersen Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 3 |
| 15 | 糖基化终末产物及其受体在胃肠道中的分布显示文摘目的:研究糖基化终末产物(advanced glycation end products,AGE)及其受体(receptor for advanced glycation end products,RAGE)在胃肠道中的分布,为进一步探索其在慢性糖尿病胃肠功能紊乱中的作用奠定基础.方法:分别对成年Wistar大鼠食管、胃、十二指肠、空肠、回肠、结肠及直肠组织进行AGE及RAGE免疫组织化学染色.结果:(1)食管:AGE及RAGE主要分布在横纹肌的肌细胞及黏膜的鳞状上皮细胞;(2)胃:AGE在壁细胞为强阳性.RAGE在主细胞、肥大细胞、神经细胞为强阳性,在壁细胞为中等强度阳性,在表面黏液细胞为弱阳性;(3)小肠:AGE及RAGE在绒毛及固有层上皮细胞为阳性或强阳性.RAGE在肠道的神经细胞亦为强阳性;(4)结肠及直肠:AGE及RAGE在黏膜上皮细胞为弱阳性,RAGE在神经细胞为强阳性.结论:AGE及RAGE广泛分布于肠道上皮细胞及食管的横纹肌细胞,AGE亦分布于胃的壁细胞,RAGE亦分布于胃的壁细胞、主细胞、表面黏液细胞、肥大细胞及胃肠道的神经细胞. | 陈朋民 赵静波 Hans Gregersen | 2012 | 世界华人消化杂志2012，20，36： | 2 |
| 16 | 在体鼠小肠应力-应变实验研究显示文摘目的 研究在体小肠生物力学特性。方法 将 1 6只Wister大鼠分为两组 ,在体组 1 0只 ,离体组 6只 ,对末端回肠做充压实验。罂粟碱腹腔注射用于抑制平滑肌的收缩。充压范围 0~ 8cmH2 O ,每 1cmH2 O为一级。充压后将肠管剪成肠环和竖条以获得肠管的无载荷和零应力状态。根据所摄图象测量的数据 ,计算Kirchhoff应力和Green应变。结果 (1 )大鼠回肠应力 -应变曲线无论在体还是离体状态均符合指数方程τ=(τ +β) eα(ε-ε ) -β(相关系数 >0 .96)。 (2 )应力 -应变曲线环向较纵向明显右移 ,在体组无论环向还是纵向均较离体组的曲线陡直。 (3 )与参照零应力状态所得应力应变曲线相比 ,参照无载荷和零压力状态所得应力应变曲线 ,在环向移向左侧 ,纵向移向右侧 ,差别有统计意义 (P <0 0 5 )。结论 (1 )回肠应力 -应变曲线关系具有非线性和各向异性特点 ,提示肠壁硬度在体状态高于离体状态 ,环向高于纵向。 (2 )将零应力状态作为基础参照对研究消化道应力 | 樊艳华 窦艳玲 Hans Gregersen | 2002 | 医用生物力学2002，17，3： | 2 |
| 17 | Changes of phasic and tonic smooth muscle function of jejunum in type 2 diabetic Goto-Kakizaki rats显示文摘AIM:To generate phasic and tonic stress-strain curves for evaluation of intestinal smooth muscle function in type 2 diabetic rats during active and passive conditions.METHODS:Seven diabetic Goto-Kakizaki(GK)male rats,32-wk old(GK group),and 9 age-matched normal Wistar rats(Normal group)were included in the study.Jejunal segments were distended up to a pressure of10 cm H2O in an organ bath containing 37℃Krebs solution with addition of carbachol(CA).The pressure and outer diameter changes were synchronously recorded.Passive conditions were obtained using calcium-free Krebs solution containing ethylene glycol tetraacetic acid and papaverine.Total phasic,tonic and passive circumferential stress and strain were computed from the diameter and pressure data with reference to the zero-stress state geometry.The active phasic and tonic stresses were defined as the total phasic and tonic stresses minus the passive stress.RESULTS:Diabetes increased jejunal mucosa and muscle layer thicknesses compared to the Normal group(mucosa,755.8±63.3 vs 633.1±59.1μm,P<0.01;muscle,106.3±12.9 vs 85.2±11.7μm,P<0.05).The pressure and stress thresholds were decreased in the GK group after CA application compared to distensions without CA application(pressure,1.01±0.07vs 1.99±0.19 cmH2O,P<0.01;stress,0.11±0.01vs 0.24±0.02 kPa,P<0.01).CA application did not change the pressure and stress threshold in the Normal group(pressure,2.13±0.32 vs 2.34±0.32 cm H2O,P>0.05;stress,0.25±0.03 vs 0.35±0.06 kPa,P>0.05).The amplitude of total phasic,total tonic,active phasic and active tonic circumferential stresses did not differ for the distensions without CA application between the GK group and the Normal group.However,the total phasic and total tonic stresses increased after CA application in the GK group compared those in the Normal group.When normalized to muscle layer thickness,the amplitude of active stresses before CA application was lowest in the GK group compared with the Normal group.No difference was found during CA application.CONCLUSION:The stress generated by intestinal muscle normalized to the muscle layer thickness was lowest in GK rats compared to normal rats whereas the response to CA stimulation was preserved. | Jing-Bo Zhao Peng-Min Chen Hans Gregersen | 2013 | World Journal of Diabetes2013，4，6： | 2 |
| 18 | Pricing policy in nature-based tourism显示文摘 | Jan G Laarman Hans M Gregersen | 1996 | Tourism Management1996，17，4： | 1 |
| 19 | New technologies in gastrointestinal research显示文摘This issue presents different new techniques aiming to increase our understanding of the gastrointestinal system and to improve treatment. The technologies cover selected methods to evoke and assess gut pain, new methods for imaging and physiological measurements, histochemistry, pharmacological modelling etc. There is no doubt that the methods will revolutionize the diagnostic approach in near future. | Asbjφrn Mohr Drewes Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 1 |
| 20 | Remodelling of the left anterior descending artery in a porcine model of supravalvular aortic stenosis显示文摘 | KASSAB GHASSAN GREGERSEN HANS NIELSEN STEN L | 2002 | Journal of Hypertension2002，20，12： | 1 |
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