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| 1 | Perinatal and early life risk factors for inflammatory bowel disease显示文摘AIM:To investigate associations between perinatal risk factors and subsequent inflammatory bowel disease (IBD) in children and young adults.METHODS:Record linked abstracts of birth registrations,maternity,day case and inpatient admissions in a defined population of southern England.Investigation of 20 perinatal factors relating to the maternity or the birth:maternal age,Crohn's disease (CD) or ulcerative colitis (UC) in the mother,maternal social class,marital status,smoking in pregnancy,ABO blood group and rhesus status,pre-eclampsia,parity,the infant's presentation at birth,caesarean delivery,forceps delivery,sex,number of babies delivered,gestational age,birthweight,head circumference,breastfeeding and Apgar scores at one and five minutes.RESULTS:Maternity records were present for 180 children who subsequently developed IBD.Univariate analysis showed increased risks of CD among children of mothers with CD (P=0.011,based on two cases of CD in both mother and child) and children of mothers who smoked during pregnancy.Multivariate analysis confirmed increased risks of CD among children of mothers who smoked (odds ratio=2.04,95% CI=1.06-3.92) and for older mothers aged 35+ years (4.81,2.32-9.98).Multivariate analysis showed that there were no significant associations between CD and 17 other perinatal risk factors investigated.It also showed that,for UC,there were no significant associations with the perinatal factors studied.CONCLUSION:This study shows an association between CD in mother and child;and elevated risks of CD in children of older mothers and of mothers who smoked. | Stephen E Roberts Clare J Wotton John G Williams Myfanwy Griffith Michael J Goldacre | 2011 | World Journal of Gastroenterology2011，17，6： | 2 |
| 2 | Microorganisms and heavy metal toxicity 显示文摘 | Gadd G M Griffiths A J | 1978 | Microb Ecol1978，4，： | 1 |
| 3 | A framework for biological criteria for Florida streams using benthic macroinvertebrates 显示文摘 | BARBOUR M T GERRITSEN J GRIFFITH G E | 1996 | Journal of the North American Benthological Society1996，15，2： | 1 |
| 4 | A framework for biological criteria for Florida streams using benthic macroinvertebrates显示文摘 | Barbour M T Gerritsen J Griffith G E | 1996 | Journal of the North American Benthological Society1996，15，： | 1 |
| 5 | Compar- ison of the quality of protection on elicited by toxoid and peptide liposomal vaccine formulations against riein as as- sessed by markers of inflammation 显示文摘 | GRIFFITHS G D PHILLIPS G J BAILEY S C | 1999 | Vaccine1999，17，： | 1 |
| 6 | Iterative Closest Geometric Objects Registration 显示文摘 | Li Q Griffiths J G | 2000 | Computers and Mathematics with Applications2000，40，10： | 1 |
| 7 | An Empirical Examina- tion of a Technology Adoption Model for the Context of China 显示文摘 | Calantone R J Griffith D A Yalcinkaya G | 2006 | Journal of International Marketing2006，，： | 1 |
| 8 | Toolpath Based on Hilbert~s Curve 显示文摘 | Griffiths J G | 1994 | Computer Aided Design1994，，11： | 1 |
| 9 | Damage by eutectic particle cracking in aluminum casting alloys A356/357显示文摘 | Wang Q G Caceres C H Griffiths J R | 2003 | Met Mater Trans A2003，34，12： | 1 |
| 10 | Anterior shoulder dislocation:Quantification of glenoid bone loss with CT显示文摘 | Griffith J F Antonio G E Tong C W | | 0，，05： | 1 |
| 11 | Phage antibodies: filamentous phage displaying anti-body variable domains显示文摘 | Mccafferty J Griffiths A D Winter G | 1990 | Nature1990，348，： | 1 |
| 12 | Specific binding of sterically stabilized ant-B-cell immunoliposomes and cytotoxicity of entrapped doxorubicin显示文摘 | Lundberg B B Griffiths G Hansen H J | 2000 | Int J Pharm2000，205，12： | 1 |
| 13 | An examination of exploration and exploitation capabilities : Implications for product innovation and market performance 显示文摘 | Yalcinkaya G Calantone R J Griffith D A | 2007 | Journal of International Marketing2007，15，4： | 1 |
| 14 | Oxygen precipitation in heavily doped silicon 显示文摘 | BAINS S K GRIFFITHS D P WILKES J G | 1990 | J Electrochem Soc1990，137，2： | 1 |
| 15 | Tool path based on Hilbert's curve显示文摘 | Griffiths J G | 1994 | Computer Aided Design1994，26，11： | 1 |
| 16 | Table-driven algorithms for generating space filling curves显示文摘 | Griffiths J G | 1985 | Computer Aided Design1985，41，7： | 1 |
| 17 | Side effects and patient acceptability of transrectal biopsy of the prostate显示文摘 | CLEMENTS R AIDEYAN O U GRIFFITHS G J | 1993 | ClinRad1993，47，： | 1 |
| 18 | Phage anti- bodies: filamentous phage displaying antibody variable domains显示文摘 | McCafferty J Griffiths AD Winter G | 1990 | Nature1990，348，6301： | 1 |
| 19 | Fatigue crack propagation in a sintered 2xxx series aluminium alloy显示文摘 | Grayson G N Schaffer G B Griffiths J R | 2006 | Mater Sci Eng A2006，434，12： | 1 |
| 20 | Management of the distal ureter during nephroureterectomy for upper urinary tract transition- al cell carcinoma: a review显示文摘 | GKOUGKOUSIS E G MELLON J K GRIFFITHS T R | 2010 | Urol Int2010，85，： | 1 |
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