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| 1 | 黄土边坡可靠度的随机有限元分析显示文摘为了研究黄土边坡的可靠度,在对黄土强度参数进行变异性统计、概率分布检验及垂直向自相关距离计算的基础上,将黄土强度参数黏聚力和内摩擦角作为随机变量,将其在二维边坡剖面的空间变化作为随机场,用局部平均细分法将符合一定均值和标准差的强度参数按随机场分布在边坡剖面的有限元网格上,再采用弹-理想塑性有限元计算边坡稳定系数,用MonteCarlo法计算其失效概率。结果表明:黄土黏聚力的变异系数多在0.30以上,内摩擦角的变异系数多在0.20以下,且黄土高原从西向东两个参数的变异性都增大;黏聚力和内摩擦角的概率分布类型对边坡失效概率计算结果影响显著,统计检验发现黏聚力采用对数正态分布、内摩擦角采用正态分布为宜;黄土地层的垂直向自相关距离多在0.7m以内,与计算厚度的比值多小于0.2;在大部分黄土的变异系数与自相关距离水平下,采用确定场进行可靠度分析,多数情况将极大地高估了黄土边坡的失效概率,而在极端高变异系数水平下,采用确定场进行可靠度分析,又将极大地低估其失效概率。 | 李萍 白健忠 GRIFFITHS D V 李同录 郑亚楠 | 2019 | 地球科学与环境学报2019，41，1： | 9 |
| 2 | High-risk corneal allografts: A therapeutic challenge显示文摘Corneal transplantation is the most common surgical procedure amongst solid organ transplants with a high survival rate of 86% at 1-year post-grafting. This high success rate has been attributed to the immune privilege of the eye. However, mechanisms originally thought to promote immune privilege, such as the lack of antigen presenting cells and vessels in the cornea, are challenged by recent studies. Nevertheless, the immunological and physiological features of the cornea promoting a relatively weak alloimmune response is likely responsible for the high survival rate in 'low-risk' settings. Furthermore, although corneal graft survival in 'lowrisk' recipients is favourable, the prognosis in 'high-risk' recipients for corneal graft is poor. In 'high-risk' grafts, the process of indirect allorecognition is accelerated by the enhanced innate and adaptive immune responses due to pre-existing inflammation and neovascularization of the host bed. This leads to the irreversible rejection of the allograft and ultimately graft failure. Many therapeutic measures are being tested in pre-clinical and clinical studies to counter the immunological challenge of 'high-risk' recipients. Despite the prevailing dogma, recent data suggest that tissue matching together with use of systemic immunosuppression may increase the likelihood of graft acceptance in 'high-risk' recipients. However, immunosuppressive drugs are accompanied with intolerance/side effects and toxicity, and therefore, novel cell-based therapies are in development which target host immune cells and restore immune homeostasis without significant side effect of treatment. In addition, developments in regenerative medicinemay be able to solve both important short comings of allotransplantation:(1) graft rejection and ultimate graft failure; and(2) the lack of suitable donor corneas. The advances in technology and research indicate that wider therapeutic choices for patients may be available to address the worldwide problem of corneal blindness in both 'low-risk' and 'high-risk' hosts. | Tian Yu Vijayalakshmi Rajendran May Griffith John V Forrester Lucia Kuffová | 2016 | World Journal of Transplantation2016，6，1： | 7 |
| 3 | Slope stability analysis by finite element显示文摘 | Griffiths D V Lane P A | 1999 | Geotechnique1999，49，3： | 1 |
| 4 | Tracking fish by airborne radar - fishermen could be the winner显示文摘 | GRIFFITHS F B LYNE V D HARRIS G P et el | 1989 | Australian Fisheries1989，48，： | 1 |
| 5 | Failure criteria interpretation based on Mohr-Coulomb friction 显示文摘 | Griffiths D V | 1990 | Journal of Geotechnical Engineering1990，116，6： | 1 |
| 6 | Slope stability analysis by finite elements显示文摘 | Griffiths D V Lane P A | 1999 | Geotechnique1999，49，3： | 1 |
| 7 | Stability of earth slopes, part II: three dimensional analysis in closed-form显示文摘 | PANTELIDIS L GRIFFITHS D V | 2013 | International Journal for Numerical and Analytical Methods in Geomechanies2013，37，13： | 1 |
| 8 | Encouraging prospects for immuni2 sation against primary cytomegalovirus infection 显示文摘 | Griffiths P Mcleam A Emery V | 2001 | Vaccine2001，19，1112： | 1 |
| 9 | Slope stability analysis by finite elements显示文摘 | Griffiths D V Lane P A | 1999 | Geo technique1999，49，3： | 1 |
| 10 | Numerical modeling of the trap door problem显示文摘 | KOUTSABELOULIS N C GRIFFITHS D V | 1989 | Gé otechnique1989，39，1： | 1 |
| 11 | Three-dimensional slope stability analysis by elasto-plastic finite elements显示文摘 | Griffiths D V Marquez R M | 2007 | Geotechnique2007，57，6： | 1 |
| 12 | In situ stress determination from inversion of hydraulic fracture data显示文摘 | HUANG Jin-song GRIFFITHS D V WONG Sau-wai | 2011 | International Journal of Rock Mechanics & Mining Sciences2011，48，： | 1 |
| 13 | Do R&D tax credits work ? Evidence from a panel countries 1979-1997显示文摘 | N Bloom R Griffith J V Reenen | 2002 | Journal o f Public Economics2002，85，1： | 1 |
| 14 | Un-drained failure mechanisms of slopes in random soil显示文摘 | Zhu H Griffiths D V Fenton G A Zhang L M | 2015 | Engineering Geology2015，191，： | 1 |
| 15 | Slope stability analysis by finite elements 显示文摘 | GRIFFITH D V LANE P A | 1999 | Geoteehnique1999，49，3： | 1 |
| 16 | Finite element modeling of settlements on spatially random soil显示文摘 | Paice G M Griffiths D V Fenton G A | 1996 | Journal of the Geotechnical Engineering Division American Society of Civil Engineering1996，122，9： | 1 |
| 17 | Encouraging prospects for immunisation against primary cytomegalovirus infection显示文摘 | Griffiths P Mcleam A Emery V | 2001 | Vaccine2001，19，1112： | 1 |
| 18 | Slope stability analysis by finiteelement显示文摘 | Griffiths D V Lane P A | 1999 | Geotechnique1999，49，3： | 1 |
| 19 | Slope Stability Analysis by Finite Element显示文摘 | Griffiths D V Lane P A | 1999 | Geotechnique1999，49，3： | 1 |
| 20 | Slope stability analysis by finite element显示文摘 | GRIFFITHS D V LANE P A | 1999 | Geotechnique1999，49，3： | 1 |
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