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| 1 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 2 | Clogging of biliary endoprosthesis: a new perspective显示文摘 | Coene P Groen A Cheng J | 1990 | Gut1990，31，： | 1 |
| 3 | Team coordination among robotic soccer players显示文摘 | Spaan M T J Groen F C A | 2009 | Journal of Control Science and Engineering2009，23，8： | 1 |
| 4 | Mechanism of hierarchical porosity development in MFI zeolites by desilication:The role of aluminium as a poredirecting agent显示文摘 | GROEN J C PEFFER L A A MOULIJN J A | 2005 | Chemisty-A European Journal2005，11，17： | 1 |
| 5 | A newly discov-ered human pneumovirus isolated from young children with respiratorytract disease显示文摘 | Van Den Hoogen BG De Jong JC Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 6 | The relation between hip impact velocity and hip impact force differs between sideways fall techniques显示文摘 | Groen BE Weerdesteyn V Duysens J | 2008 | J Electromyogr Kineol2008，18，2： | 1 |
| 7 | A newly discovered human pneumovirus isolated from young children with respiratory tract disease显示文摘 | van den Hoogen BG de Jong JC Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 8 | Use of recombinant nucleoproteins in enzyme-linked immunosorbent assays for detection of virus-specific immunoglobulin A or B infected patients显示文摘 | Voeten J T Groen J Van Alphen D | 1998 | J Clin Microbiol1998，36，12： | 1 |
| 9 | Formation of uniform mesopores in ZSM-5 zeolite upon alkaline post-treatment显示文摘 | GROEN J C PEREZ R J PEFFER L A A | 2002 | Chemistry Letters2002，31，1： | 1 |
| 10 | Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulfate-glycosaminoglycan depleted cartilage 显示文摘 | Siebelt M Groen HC Koelewijn S J | 2014 | Arthritis Res Ther2014，16，1： | 1 |
| 11 | Analysis of the UK diagnostic strategy for limb girdle muscular dystrophy 2A 显示文摘 | Groen E J Charlton R Barresi R | 2007 | Brain2007，130，12： | 1 |
| 12 | A newly discovered human pneumovirus isolated from young respiratory tract disease 显示文摘 | van den Hoogen BG de Jong JC Groen J | 2001 | Nat Med2001，7，6： | 1 |
| 13 | Left ventricular remodeling in the first year after acute myocardial infarction and the predictive value of N-terminal pro brain natriuretic peptide 显示文摘 | Nilsson J C Groenning B A Nielsen G | 2002 | American Heart Journal2002，143，4： | 1 |
| 14 | Utilizing full-exchange capacity of zeolites by alkaline leaching: preparation of Fe-ZSM-5 and application in N2O decomposition 显示文摘 | Melian-Cebrera I Espinosa S Groen J C | 2006 | J Catal2006，238，2： | 1 |
| 15 | Respiratory syncytial virus specific serum antibodies in infants under sixmonths of age:limited serological response upon infection显示文摘 | BRANDENBURG A H GROEN J VAN STEENSEL-MOLL H A | 1997 | Med Virol1997，52，1： | 1 |
| 16 | The prognostic value of histology in the assessment of patients with Budd–Chiari syndrome显示文摘 | Thjon J Tang Kenneth P Batts Piet C de Groen Bart van Hoek Elizabeth B Haagsma Wim C.J Hop Harry L.A Janssen | 2001 | Journal of Hepatology2001，，3： | 1 |
| 17 | Active Nerccl protein kinase concentrates at centrosomes early in mitosis and is necessary for proper spindle assembly显示文摘 | Roig J Groen A Caldwell J | 2005 | Mol Cell Biol2005，16，48： | 1 |
| 18 | Extraction, isolation,and structure of a new phenolic constituent of female urine显示文摘 | Roy S Toumba S Groen J K | 1980 | Nature1980，287，： | 1 |
| 19 | Detection of left ventricular enlargement and impaired systolic function with plasma Nterminal pro brain natriuretic peptide concentrations 显示文摘 | Groenning B A Nilsson J C Sondergaard L | 2002 | American Heart Journal2002，143，5： | 1 |
| 20 | Influenza virus serologya comparative study显示文摘 | Rothbarth PH Groen J Bohnen AM | 1999 | J virol Methods1999，78，12： | 1 |
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