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| 1 | Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies显示文摘AIM To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal adenoma.METHODS Pub Med and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein(CRP), interleukin-6(IL-6), and tumor necrosis factor-alpha(TNF-a) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios(ORs) with 95%CIs for the highest vs lowest category of exposure. Heterogeneity was assessed by using the Q test and I2 statistic. Subgroup analyses were also performed to test for potential source of heterogeneity.RESULTS A total of 14 case-control studies were included. Ten studies on CRP including a total of 3350 cases and 4168 controls showed non-significant summary(OR = 1.23, 95%CI: 0.98-1.54; I2 = 54%, P heterogeneity = 0.01) in the general analysis, but significant increased odds when considering only advanced adenoma(OR = 1.59, 95%CI: 1.09-2.32; I2 = 44%, P heterogeneity = 0.15). Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma. Five studies examined the association between circulating levels of TNF-a and colorectal adenoma risk, including a total of 1,568 cases and 2,832 controls. The summary OR for the highest vs the lowest category of exposure was 1.00(95%CI: 0.77-1.29). The relationship between circulating IL-6 levels and colorectal adenoma risk was investigated in 7 studies including a total of 1936 cases and 3611 controls. The summary OR for the highest vs the lowest category of exposure was 1.19(95%CI: 0.92-1.55).CONCLUSION Summary of current evidence suggests a positive association of CRP levels and advanced colorectal adenoma risk. The role of potential confounding factors should be further evaluated. | Justyna Godos Antonio Biondi Fabio Galvano Francesco Basile Salvatore Sciacca Edward L Giovannucci Giuseppe Grosso | 2017 | World Journal of Gastroenterology2017，23，10： | 5 |
| 2 | Nanocrystalline transition-metal oxide spheres with controlled multi-scale porosity 显示文摘 | Grosso D Soler Illia G J de A A Crepaldi E L | 2003 | Adv Funct Mater2003，13，1： | 1 |
| 3 | Antibiotic - resistant inva- sive pneumoeoeeal clones in Italy显示文摘 | Gherardi G Fallieo L /)el Grosso M | 2007 | J Clin Mierobiol2007，45，2： | 1 |
| 4 | SCN1A mutation associated with atypical Panayiotopoulos syndrome 显示文摘 | Grosso S Orrico A Galli L | 2007 | Neurology2007，69，： | 1 |
| 5 | Efficiency of energy recovery from waste incineration,in the light of the new Waste Framework Directive显示文摘 | GROSSO M MOTTA A RIGAMONTI L | 2010 | Waste Management2010，，30： | 1 |
| 6 | Chemometry as applied to the production of omega- 3 microcapsules by complex coacervation with soy protein isolate and gum Arabic 显示文摘 | de Conto L C Grosso C R F Gonqalves L A G | 2013 | LWT - Food Science and Technology2013，53，1： | 1 |
| 7 | Precocious puberty with trisomy X syndrome显示文摘 | Grosso S Berardi R Pucci L | 1999 | Obstet Gynecol1999，94，52： | 1 |
| 8 | Block copolymer-templated mesoporous oxides显示文摘 | Soler-Illia G J A A Crepaldi E L Grosso D | 2003 | Current Opinion in Colloid and Interface Science2003，8，1： | 1 |
| 9 | Characterization of Macrolide efflux pump mef subclasses detected in clinical iso- lates of Streptococcus pyogenes isolated between 1999 and 2005显示文摘 | BLACKMAN NORTHWOOD J DEL GROSSO M COSSINS L R | 2009 | Antimicrob Agents Chemother2009，53，5： | 1 |
| 10 | A unique mucin immunoenhancing peptide with antitumor properties显示文摘 | HERBERT L M GROSSO J F DORSEY M J R | 2004 | Cancer Res2004，64，21： | 1 |
| 11 | Effect of fatty acids and Brazilianelemi on composite films based on gelatin显示文摘 | Bertan L C Tanada-Palmu P S Siani A C Grosso C R F | 2005 | Food Hydrocolloids2005，19，1： | 1 |
| 12 | Caffeine metabolism, genetics, and perinatal outcomes:a review of exposure assessment considerations during pregnancy显示文摘 | Grosso L M Bracken M B | 2005 | Ann Ep idemiol2005，15，： | 1 |
| 13 | Gancyclovir-induced megakaryocyte loss in chronic myelogenous leukemia post bone-marrow transplant显示文摘 | Gardner L Grosso L E | 1996 | Am-J-Hematol1996，53，3： | 1 |
| 14 | Phenotypic alterations in Kaposi's sarcoma cells by antisense reduction of perlecan显示文摘 | MARCHISONE C DEL GROSSO F MASIELLO L | 2000 | Pathol On- col Res2000，6，： | 1 |
| 15 | Block Copolymer-Templated Mesoporous Oxides显示文摘 | Soler-Illia G J A A Crepaldi E L Grosso D | 2003 | Curr Opin Colloid Interface Sci2003，8，1： | 1 |
| 16 | The multifacet- ed aspects of interstitial lung disease in rheumatoid ar- thritis显示文摘 | Cavagna L Monti S Grosso V | 2013 | Biomed Res Int2013，2013，： | 1 |
| 17 | Effect of nitrogen ion irradiation on the nano-tribological and surface mechanical properties of ultra-high molecular weight polyethylene 显示文摘 | Fasce L Cur J Grosso M D | 2010 | Surface and Coatings Technology2010，204，： | 1 |
| 18 | Caffeien metabolism,genetics,and perinatal outcome:A review of exposure assessment consideration during pregnancy显示文摘 | Grosso L M Bracken M B | | 0，，05： | 1 |
| 19 | Controlled formation of highly organized mesopomus titania thin films: From mesostruetured hybrids to mesopomus nanoanatase TiO2 显示文摘 | Crepaldi E L Soler-Illia G J A A Grosso D | 2003 | Journal of the American Chemical Society2003，125，32： | 1 |
| 20 | Controlled formation of highly organized mesoporous titania thin films: From mesostructured hybrids to mesoporous nanoanatase TiO2 显示文摘 | CREPALDI E L SOLERIIA G J GROSSO D CAGNOL F RIBOT F SANCHEZ C | 2003 | J Am Chem Soc2003，125，： | 1 |
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