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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | 流感病毒传播能力相关遗传机制的深度解析显示文摘在人与人之间通过呼吸道高效传播的能力是新发流感病毒引起人流感大流行的先决条件,但流感病毒传播能力遗传决定因素至今并不完全清楚。揭示流感病毒传播能力遗传机制对人流感大流行的预警以及防控疫苗和药物研发都至关重要,因此一直是病毒学领域研究的重点。2013年出现在我国的H7N9亚型禽流感病毒已导致1560多人感染,致死率近40%。 | Kong H Ma S Wang J Gu C | 2019 | 中国预防兽医学报2019，41，11： | 5 |
| 3 | Inhibition of extracellular signal-regulated kinase enhances Ischemia/Reoxygenation-induced apoptosis in cultured cardiac myocytes and exaggerated reperfusion injury in isolated peffusod heart 显示文摘 | Yue T L Wang C Gu J L | 2000 | Circ Res2000，86，6： | 2 |
| 4 | Direct shear test of sandstone-concrete joints显示文摘 | GU X F SEIDEL J P HABERFIELD C M | 2003 | International Journal of Geomechanics2003，3，1： | 1 |
| 5 | Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats显示文摘 | Liu C Wu J Gu J | 2007 | Pharmacol Biochem Behav2007，86，3： | 1 |
| 6 | Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats显示文摘 | LIU C WU J GU J | 2007 | Pharmacol Biochem Behav2007，86，： | 1 |
| 7 | Field emission properties of diamond- like carbon films annealed at different temperatures 显示文摘 | LI J J GU C Z PENG H Y | 2005 | Applied Surface Science2005，251，14： | 1 |
| 8 | Capecitabine plus oxaliplatin compared with 5-fluorouracil plus oxaliplatin in metastatic colorectal cancer:Meta-analysis of randomized controlled trials显示文摘 | Zhang C Wang J Gu H | 2012 | Oncol Lett2012，3，4： | 1 |
| 9 | Functional case modelling for know- ledge-driven conceptual design显示文摘 | GU C HU J PENG Y | 2012 | Proceedings of the Institu- tion of Mechanical Engineers Part B Journal of Engineering Manufacture2012，226，4： | 1 |
| 10 | High corrosion-resistance nanocrystalline Ni coating on AZ91D magnesium alloy显示文摘 | LIAN J S HE J G | 2006 | Surf Coat Technol2006，200，1819： | 1 |
| 11 | Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China 显示文摘 | Wang Y C Zhang H Y Xia N S Peng G Lan H Y Zhuang H Zhu Y H Li S W Tian K G Gu W J Lin W J Wu J X Li X Harrison T J | 2002 | Journal of Medical Virology2002，67，4： | 1 |
| 12 | Implicit uncertainty propagation for robust collaborative optimization显示文摘 | GU X Y RENAUD J E PENNINGER C L | 2006 | Journal of Mechanical Design2006，128，4： | 1 |
| 13 | Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats显示文摘 | Liu C Wu J Gu J | 2007 | Pharmacol Biochem Behav2007，86，3： | 1 |
| 14 | On time-like surfaces of positive constant Gaussian curvature and imaginary principal curvatures显示文摘 | Gu C H Hu H S Inoguchi J | 2002 | J Geom Phys2002，41，： | 1 |
| 15 | Serum levels of matrix metalloproteinase 3 and macrophage colony-stimulating factor 1 correlate with disease activity in ankylosing spondylitis显示文摘 | Yang C Gu J RihlM | 2004 | Arthritis Rheum2004，51，： | 1 |
| 16 | Effects of dopamine and norepinephrine on systemic and hepatosplanchnic hemodynamics,oxygen exchange,and energy balance in vasoplegic septic patients显示文摘 | Gu(e)rin JP Levraut J Samat-Long C | | 0，，： | 1 |
| 17 | Accurate on-line v-support vector learning显示文摘 | Gu B Wang J D Yu Y C | 2012 | Neural Networks2012，27，： | 1 |
| 18 | Simple adjoint retrievals of microburst winds from single-Doppler radar data显示文摘 | Xu Q Qiu C J Gu H D | 1995 | Mon Wea Rev1995，123，： | 1 |
| 19 | Study on preparation and fire retardant mechanism analysis of intumescent flame-retardant coatings 显示文摘 | GU J W ZHANG G C DONGS L | 2007 | Surf Coat Technol2007，201，： | 1 |
| 20 | Clinical implications and prognostic value of EMMPRIN/CD147 and MMP2 expression in pediatric gliomas显示文摘 | Gu J Zhang C Chen R | 2009 | Eur J Pediatr2009，168，6： | 1 |
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