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| 1 | Chinese medicine formulas for nonalcoholic fatty liver disease: Overview of systematic reviews显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)affects more than one-quarter of the global population.Due to the lack of approved chemical agents,many patients seek treatment from traditional Chinese medicine(TCM)formulas.A variety of systematic reviews have been published regarding the effectiveness and safety of TCM formulas for NAFLD.AIM To critically appraise available systematic reviews and sort out the high-quality evidence on TCM formulas for the management of NAFLD.METHODS Seven databases were systematically searched from their inception to 28 February 2020.The search terms included“non-alcoholic fatty liver disease,”“Chinese medicines,”“systematic review,”and their synonyms.Systematic reviews involving TCM formulas alone or in combination with conventional medications were included.The methodological quality and risk of bias of eligible systematic reviews were evaluated by using A Measure Tool to Assess Systematic Reviews 2(AMSTAR 2)and Risk of Bias in Systematic Review(ROBIS).The quality of outcomes was assessed by the Grading of Recommendations Assessment,Development and Evaluation(GRADE)system.RESULTS Seven systematic reviews were ultimately included.All systematic reviews were conducted based on randomized controlled trials and published in the last decade.According to the AMSTAR 2 tool,one systematic review was judged as having a moderate confidence level,whereas the other studies were rated as having a low or extremely low level of confidence.The ROBIS tool showed that the included systematic reviews all had a high risk of bias due to insufficient consideration of identified concerns.According to the GRADE system,only two outcomes were determined as high quality;namely,TCM formulas with the HuoXueHuaYu principle were better than conventional medications in ultrasound improvement,and TCM formulas were superior to antioxidants in alanine aminotransferase normalization.Other outcomes were downgraded to lower levels,mainly because of heterogeneity among studies,not meeting optimal information sample size,and inclusion of excessive numbers of small sample studies.Nevertheless,the evidence quality of extracted outcomes should be further downgraded when applying to clinical practice due to indirectness.CONCLUSION The quality of available systematic reviews was not satisfactory.Researchers should avoid repeatedly conducting systematic reviews in this area and focus on designing rigorous randomized controlled trials to support TCM formula applications. | Liang Dai Wen-Jun Zhou Linda L D Zhong Xu-Dong Tang Guang Ji | 2021 | World Journal of Clinical Cases2021，9，1： | 3 |
| 2 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 3 | Development of a remote analysis method for underground ventilation systems using tracer gas and CFD in a simplified laboratory apparatus显示文摘 | XU Guang Kray D Luxbacher Saad Ragab | 2013 | Tunnelling and Underground Space Technolo- gy2013，28，3： | 1 |
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| 6 | A stress calculation model for the 3D borehole slotter显示文摘 | Corthesy R He Guang Gill D E | 1999 | International Journal of Rock Mechanics and Mining Sciences1999，36，3： | 1 |
| 7 | Plant food-derived angiotensin I converting enzyme inhibitory peptides显示文摘 | C Guang R D Phillips | 2009 | Journal of Agricultural and Food Chemistry2009，57，12： | 1 |
| 8 | Multiresolution Analysis for Reconstruction of Conductivity Profiles in Eddy Current Nondestructive Evaluation Using Probe Impedance Data显示文摘 | Shao K R Guo You Guang and Lavers J D | 2004 | IEEE transactions on magnetics2004，40，4： | 1 |
| 9 | All - Optical Switching in A New Polydiacetylene 显示文摘 | Xu H Y Guang S Y Xu D | 1996 | Mat Res Bull1996，31，4： | 1 |
| 10 | Plant food-derived angiotensin Iconverting enzyme inhibitory peptides 显示文摘 | GUANG C PHILLIPS R D | 2009 | Journal of Agricultural andFood Chemistry2009，57，： | 1 |
| 11 | State feedback control of uncertain networked control systems with random time delays显示文摘 | HUANG D GUANG S K | 2008 | IEEE Transactions on Automatic Control2008，53，3： | 1 |
| 12 | Improving protein secondary structure prediction by using the residue conformational classes显示文摘 | GUANG Z Z HUANG D S ZHU Y P | 2005 | Pattern Recognition Letters2005，26，： | 1 |
| 13 | Plant food-derived angiotensin I converting enzyme inhibitory peptides 显示文摘 | Guang C Phillips R D | 2009 | Journal of Agricultural and Food Chemistry2009，57，12： | 1 |
| 14 | Cellular mech- anisms underlying affective resiliency: the role of glucocorticoid receptor-and mitochondrially-mediated plasticity显示文摘 | Hunsberger J G Austin D R Chen Guang | 2009 | Brain Res2009，1293，： | 1 |
| 15 | Multi-agent control algorithms for chemical cloud detection and mapping using unmanned air vehicles显示文摘 | Kovacina M A Palmer D Guang Y | 2002 | Intelligent Robots and Systems2002，，3： | 1 |
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| 17 | Status of urban vegetation in Guangzhou 显示文摘 | GUANG D S CHEN Y J | 2003 | For Res2003，14，3： | 1 |
| 18 | Adaptive neural net- work feedforward control for dynamically substructured sys- tems 显示文摘 | Li Guang Na Jing Stoten D P | 2014 | IEEE Transactions on Control Systems Technolo- gy2014，22，3： | 1 |
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| 20 | Terpenoids from the seeds of Artemisia annua显示文摘 | Geoffrey D Brown Guang Yi Liang | 2003 | Phytochemistry2003，64，1： | 1 |
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