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| 1 | Modern management of rectal cancer: A 2006 update显示文摘The goal of this review is to outline some of the important surgical issues surrounding the management of patients with early (T1/T2 and NO), as well as locally advanced (T3/T4 and/or N1) rectal cancer. Surgery for rectal cancer continues to develop towards the ultimate goals of improved local control and overall survival, maintaining quality of life, and preserving sphincter, genitourinary, and sexual function. Information concerning the depth of tumor penetration through the rectal wall, lymph node involvement, and presence of distant metastatic disease is of crucial importance when planning a curative rectal cancer resection. Preoperative staging is used to determine the indication for neoadjuvant therapy as well as the indication for local excision versus radical cancer resection. Local excision is likely to be curative in most patients with a primary tumor which is limited to the submucosa (T1N0M0), without high-risk features and in the absence of metastatic disease. In appropriate patients, minimally invasive procedures, such as local excision, TEM, and laparoscopic resection allow for improved patient comfort, shorter hospital stays, and earlier return to preoperative activity level. Once the tumor invades the muscularis propria (T2), radical rectal resection in acceptable operative candidates is recommended. In patients with transmural and/or node positive disease (T3/T4 and/or N1) with no distant metastases, preoperative chemoradiation followed by radical resection according to the principles of TME has become widely accepted. During the planning and conduct of a radical operation for a locally advanced rectal cancer, a number of surgical management issues are considered, including: (1) total mesorectal excision (TME); (2) autonomic nerve preservation (ANP); (3) circumferential resection margin (CRM); (4) distal resection margin; (5) sphincter preservation and options for restoration of bowel continuity; (6) laparoscopic approaches; and (7) postoperative quality of life. | Glen C Balch Alex De Meo Jose G Guillem | 2006 | World Journal of Gastroenterology2006，12，20： | 26 |
| 2 | ASCO/SSO re-view of current role of risk-reducing surgery in common he-reditary cancer syndromes显示文摘 | Guillem J G Wood W C Moley J F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 3 | A phase ll,randomized, controlled trial of acupuncture tor reduction of Postcolectomy Ileus显示文摘 | Deng G Wong D W Guillem J | 2013 | Ann Surg Oncol2013，20，4： | 1 |
| 4 | Distinct pattern of matrix metalloproteinase 9 and tissue inhibitor of metallopreteinase 1 mRNA expression in human colorectal cancer and liver metastases 显示文摘 | ZENG Z S GUILLEM J G | 1995 | Br J Cancer1995，72，3： | 1 |
| 5 | Coloealisation of matrix metalloproteinase-9mRNA and protein in human colorectal cancer stromal cells显示文摘 | Zeng Z S Guillem J G | 1996 | Br J Cancer1996，74，8： | 1 |
| 6 | Anastomotic leak is not associated with oncologic outcome in patients undergoing low anterior resection for rectal cancer显示文摘 | SMITH J D PATY P B GUILLEM J G | 2012 | Annals of surgery2012，256，6： | 1 |
| 7 | Surgical treatment ofcolorectal cancer显示文摘 | Guillem S G Pofy PB Cohem AM | 1997 | Cancer J Clin1997，47，2： | 1 |
| 8 | Nonlinear initial-value problems and Schauder bases 显示文摘 | Gaamez D Guillem A I G Galan M R | 2005 | Nonlinear Anal2005，63，： | 1 |
| 9 | Surgical treatment of colorectal Cancer显示文摘 | GUILLEM J G PATY P B COHEN A M | 1997 | CA Cancer J Clin1997，47，2： | 1 |
| 10 | How to make a Barrett esophagus:pathophysiology of columnar metaplasia of the esophagus显示文摘 | GUILLEM P G | 2005 | Dig Dis Sci2005，50，： | 1 |
| 11 | Surgical treatment of colorectal cancer显示文摘 | Guillem J G Paty P B Cohen A M | 1997 | CA Cancer J Clin1997，47，2： | 1 |
| 12 | Surgical issues in rectal cancer: a 2004 update显示文摘 | Chessin D B Guillem J G | 2004 | Clin Colorectal Cancer2004，4，4： | 1 |
| 13 | Loss of basement membrane type V collagen is associated with increased expression of metallo protemases 2 and 9(MMP-2 and MMP-9) during human colorectal tumorigenesis显示文摘 | Zeng ZS Cohen A M Guillem J G | 1999 | Carcingenesis1999，20，5： | 1 |
| 14 | Surgical treatment of colorectal cancer显示文摘 | Guillem J G Paty P B Cohen A M | 1997 | CA Cancer J Clin1997，47，2： | 1 |
| 15 | Autonomic nerve preservation during rectal cancer resection显示文摘 | Jose G Guillem S A Lee K | 2010 | J Gastrointest Surg2010，14，： | 1 |
| 16 | Major 20th century advancements in the management of rectal cancer显示文摘 | Leyo R Guillem J G | 1999 | Dis Colon Rectum1999，42，： | 1 |
| 17 | Gastrointestinal polyposis syndromes显示文摘 | Guillem J G Smith A J Calle J P | 1999 | Curr Probl Surg1999，36，4： | 1 |
| 18 | The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized 显示文摘 | Steinhagen E Guillem JG Chang G | 2012 | Clin Colorectal Cancer2012，11，4： | 1 |
| 19 | Effect of polyethylene glycol-electrolyte lavage solution on intestinal microflora 显示文摘 | Morotomi M Guillem J G Pocsidio J | 1989 | Appl Environ Microbiol1989，55，4： | 1 |
| 20 | Loss of basement membrane type Ⅳ collagen is associated with increased expression of metalloproteinases 2 and 9 (MMP-2 and MMP-9) during human colorectal tumorigenesis显示文摘 | Zeng Z S Cohen A M Guillem J G | 1999 | Carcinogenesis1999，20，5： | 1 |
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