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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | 新型冠状病毒肺炎患者肝生化学检查异常的发生率、危险因素及预后:一项系统性评价和荟萃分析显示文摘【据Hepatol Int 2020年7月报道】题:新型冠状病毒肺炎患者肝生化学检查异常的发生率、危险因素及预后:一项系统性评价和荟萃分析(作者Wu Y等)新型冠状病毒肺炎(COVID-19)正在全球大流行。除肺损伤外,COVID-19患者还有可能发生肝损伤。 | WU Y LI H GUO X 吴艳艳(报道) 祁兴顺(报道) | 2020 | 临床肝胆病杂志2020，36，12： | 5 |
| 3 | Competition between radiation damping and transverse relaxation effects on NMR signal intensities 显示文摘 | Mao X A Guo J X Ye C H | 1994 | Chem Phys Lett1994，218，： | 2 |
| 4 | Chromosome segregation in fertilized eggs from triploid pacific oysters, Crassostrea gigas (Thunberg), following inhibition of polar body Ⅰ 显示文摘 | Que H Y Guo X M Zhang F S | 1997 | Biol Bull1997，193，： | 1 |
| 5 | Comparison study of the effects of temperature and flee ammonia concentration on nitrification and nitrite accumulation 显示文摘 | Kim J H Guo X J Park H S | 2008 | Process Biochemistry2008，43，2： | 1 |
| 6 | Lithium insertion in Si-TiC nanocomposite materials produced by high-energy mechanical milling显示文摘 | GUO Z P ZHAO Z W LIU H K DOU S X | 2005 | J Power Sources2005，146，： | 1 |
| 7 | Study of multi-monomer melt-grafting onto polypropylene in an extruder显示文摘 | Chen NH Guo B H | 2000 | Polymer International2000，49，： | 1 |
| 8 | Electrocatalytic properties of platinum on hard carbon spherules derived from deoiled asphalt for methanol oxidation显示文摘 | Xu B S Guo J J Jia H S Yang X W Liu X G | 2007 | Catalysis Today2007，125，34： | 1 |
| 9 | Genetic analysis of a novel dominant rice dwarf mutant 986083D显示文摘 | Qin R Z Qiu Y Cheng Z J Shan X Y Guo X P Zhai H Q Wan J M | 2008 | Euphytica2008，160，： | 1 |
| 10 | A novel LS-SVM hyper-parameter selection based on particle swarm optimization显示文摘 | Guo X C Yang J H Wu C G et rd | 2008 | Neurocomputing2008，71，1618： | 1 |
| 11 | Comparative analysis of the mitochon drial DNA control region in cyprinids with different ploidy level 显示文摘 | Guo X H Liu S J Liu Y | 2003 | Aquaculture2003，224，14： | 1 |
| 12 | Plant proteomics in the post-genomic era显示文摘 | Guo Y M Shen S H Jing Y X | 2002 | Acta Bot Sin2002，44，6： | 1 |
| 13 | Location and migration of cations in Cu2+-adsorbed montmorillonite显示文摘 | H P He J G Guo X D Xie | 2001 | Environment International2001，26，： | 1 |
| 14 | A H∞ control method of the bullwhip effect for a class of supply chain systems显示文摘 | Huang X Y Yan N N Guo H F | 2007 | Int J of Production Research2007，45，7： | 1 |
| 15 | A novel and low-temperation hydrothermal synthesis of SnO2 nanorod显示文摘 | Guo C X Cao M H Hu C W | 2004 | Inorganic Chemistry Communication2004，7，： | 1 |
| 16 | Weyl's theorem for upper triangular operator matrices显示文摘 | CAO X H GUO M Z MENG B | 2005 | Linear Algebra and its Applications2005，，402： | 1 |
| 17 | KAI-1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases显示文摘 | Guo X Friess H Graber HU | 1996 | Cancer Res1996，56，21： | 1 |
| 18 | B, As, and F contamination of river water due to wastewater discharge of the Yangbajing geothermal power plant, Tibet, China 显示文摘 | Guo Q H Wang Y X Liu W | 2008 | Environmental Geology2008，56，1： | 1 |
| 19 | Mitofusin2 triggers vascular smooth cell apoptosis vis mitochondrial death pathway 显示文摘 | Guo X M Chen K H Guo Y H | 2007 | Circ Res2007，101，11： | 1 |
| 20 | Hot water extract of the sclerotium of Polyporus rhinocerus Cooke enhances the immune functions of murine macrophages 显示文摘 | Guo C X Wong K H Cheung P C K | 2011 | International Journal of Medicinal Mushrooms2011，13，3： | 1 |
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