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| 1 | Effects of partial portal vein arterialization on the hilar bile duct in a rat model显示文摘BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P<0.01). No apoptotic hilar bile duct epithelial cells were detected in any of the groups. The PBP arteriolar counts of the hilar bile duc wall were similar in groups A and C (P>0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation. | Shao-Hua Guo, Chong-Hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (Guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo SH), General Hospital of PLA, Beijing 100853, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 8 |
| 2 | Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg显示文摘 | He XW Wang F Jiang L Li J Liu SK Xiao ZY Jin XQ Zhang YN He Y Li K Guo YJ Sun SH | 2005 | 第二军医大学学报2005，26，10： | 5 |
| 3 | Molecular cloning and functional characterization of porcine toll - like receptor 7 involved in recognition of single - stranded RNA virus/ssRNA 显示文摘 | Zhang YL Guo YJ Sun SH | 2008 | Mol lnununol2008，45，4： | 1 |
| 4 | Association of red cell distribution width with the presence of coronary artery ectasia显示文摘 | Guo YL Luo SH Tang Y | 2014 | Clin Lab2014，60，2： | 1 |
| 5 | Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress:a rat model of post-stroke depression显示文摘 | Wang SH Zhang ZJ Guo YJ | | 0，，： | 1 |
| 6 | Preparative isolation of triterpenoids from Ganoderma lucidum by counter-current chromatography combined with pH-zone-refining 显示文摘 | Cheng CR Li YF Xu PP Feng RH Yang M Guan SH Guo DA | 2012 | Food Chem2012，130，： | 1 |
| 7 | SINAT5 promotes ubiquitin-related degradation of NAC1 to attenuate auxin signals显示文摘 | XIE Q GUO H S DALLMAN G FANG SH Y WEISSMAN A M CHUA N H | 2002 | Nature2002，419，： | 1 |
| 8 | Rheological,texture and sensory properties of low-fat mayonnaise with different fat mimetics 显示文摘 | Liu H Xu X M Guo Sh D | 2007 | LWT-Food Science and Technology2007，40，6： | 1 |
| 9 | Escheriehia coli outer membrane protease OmpT con- fers resistance to urinary cationic peptides 显示文摘 | Hui CY Guo Y He QS Peng L Wu SC Cao H Huang SH | 2010 | Microbiol Immunol2010，54，8： | 1 |
| 10 | Involvement of serotonin neurotransmission in hippocampal neurogenesis and behavioral responses in a rat model of post-stroke depression显示文摘 | Wang SH Zhang ZJ Guo YJ | | 0，，： | 1 |
| 11 | Observations on the flora and vegetation of Taibai Shan, Qinling Mountain Range, Southern Shaanxi, China显示文摘 | YING J SH(应俊生) LI Y F(李云峰) GUO Q F(郭勤峰) | 1990 | Acta Phytotaxonomica Sinica (植物分类学报)1990，28，4： | 1 |
| 12 | Protection of pigs against taenia solium cysticercosis using recombinant antigen or in combination with DNA vaccine显示文摘 | Guo YJ Sun SH Zhang Y | | 0，，29： | 1 |
| 13 | Characterization of modified nanoscale ZSM-5 catalyst and its application in FCC gasoline upgrading process显示文摘 | ZHAO X B GUO X W WANG X SH | 2006 | Engery Fuels2006，20，4： | 1 |
| 14 | A boundary method for outlier detection based on support vector domain de- scription 显示文摘 | GUO S M CHEN L C TSAI J SH | 2009 | Pattern Recognition2009，42，1： | 1 |
| 15 | Effects of mebendazole, albendazole, and praziquantel on fumarate hydratase, pyruvate kinase, and phosphoenolpyruvate carboxykinase of Echinococcus granulosus cyst wall harbored in mice显示文摘 | Xiao SH Feng JJ Guo HF | 1994 | Acta Pharmacol Sin1994，，15： | 1 |
| 16 | 16S rRNA gene probe quantitates residual host cell DNA in pharmaceutical-grade plasmid DNA 显示文摘 | Wang KY Guo YJ Sun SH | 2006 | Vaccine2006，24，14： | 1 |
| 17 | Effect of hydrothermal treatment temperature on FCC gasoline upgrading properties of the modified nanoscale ZSM-5 catalyst显示文摘 | ZHAO X B GUO X W WANG X SH | 2007 | Fuel Process Technol2007，88，3： | 1 |
| 18 | Effects of mebendazole, albendazole, and praziquantel on alkaline phosphatase, acid phosphatase, and adenosine triphosphatase of Echinococcus granulosus cysts harbored in mice显示文摘 | Feng JJ Xiao SH Guo HF | 1992 | Acta Pharmacol Sin1992，，13： | 1 |
| 19 | Involvement of sero- tonin neurotransmission in hippocampal neurogenesis and be- havioral responses in a rat model of post-stroke depression 显示文摘 | Wang SH Zhang Z J Guo Y J | 2010 | Pharmacol Biochem Behav2010，95，1： | 1 |
| 20 | A piezoelectric immunosensor for specific capture and enrichment of viable pathogens by quartz crystal microbalance sensor, followed by detection with antibody functionalized gold nanoparticles显示文摘 | Guo X Lin CS Chen SH | 2012 | Biosens Bioelectron2012，38，1： | 1 |
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