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| 1 | Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP: A single center experience显示文摘AIM: To identify potential factors that can predict adverse short-term outcomes in patients with acute cholangitis undergoing endoscopic retrograde cholangiopancreatography(ERCP). METHODS: Retrospective analysis of consecutive patients admitted to our center for acute cholangitis and underwent ERCP from 2001 to 2012. Involvement of two or more organ systems was termed as organ failure(OF). Cardiovascular failure was defined based on a systolic blood pressure of < 90 mmHg despite fluid replacement and/or requiring vasopressor treatment; respiratory failure if the Pa02 /Fi02 ratio was < 300 mmHg and/or required mechanical ventilation; coagulopathy if the platelet count was < 80; and renal insufficiency if serum creatinine was > 1.9 mg/dL. Variables associated with short term adverse clinical outcomes defined as persistent OF and/or 30-d mortality was determined. RESULTS: A total of 172 patients(median age 62 years, 56.4% female) were included. The median door to ERCP time was 17 h. Bile duct stones were the most common etiology(n = 67, 39.2%). In multivariate analysis, factors that were independently associated with persistent OF and/or 30-d mortality included American Society of Anesthesiology(ASA) physical classification score > 3(OR = 7.70; 95%CI: 2.73-24.40), presence of systemic inflammatory response syndrome(OR = 3.67; 95%CI: 1.34-10.3) and door to ERCP time greater than 72 h(OR = 3.36; 95%CI: 1.12-10.20). Door to ERCP time greater than 72 h was also associated with 70% increase in the mean length of stay(P < 0.001). Every one point increase in the ASA physical classification and every 1 mg/dL increase in the preERCP bilirubin level was associated with a 34% and 2% increase in the mean length of hospital stay, respectively. Transfer status did not impact clinical outcomes. CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergoing ERCP. | Udayakumar Navaneethan Norma G Gutierrez Ramprasad Jegadeesan Preethi GK Venkatesh Madhusudhan R Sanaka John J Vargo Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 2 | Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro显示文摘 | GARRETT I R CHEN D GUTIERREZ G | 2003 | J Clin Invest2003，111，11： | 1 |
| 3 | Arginine addition in the sta- tionary phase influences the fermentation rate and synthesis of aroma compounds in a synthetic must fermented by three commercial wine strains 显示文摘 | GUTIERREZ A CHIVA R JOSE M G | 2015 | LWT-Food Sei Technol2015，60，2： | 1 |
| 4 | Variation in vegetation and seed bank in Chilean semi-arid community affected by ENSO 1997 显示文摘 | GUTIERREZ J R ARANCIO G JAKSIC F M | 2000 | Joural of Vegetaion Science2000，11，： | 1 |
| 5 | Statins and bone formation 显示文摘 | GARRETT I R GUTIERREZ G MUNDY G R | 2001 | Curr Pharm Des2001，7，8： | 1 |
| 6 | The Europe- anhigh-speed train network predicted effects in accessibility patterns显示文摘 | GUTIERREZ J GONXALEZ R GOMEZ G | 1996 | Journal of Transport Geography1996，4，4： | 1 |
| 7 | A continuous review inventory model with order expediting显示文摘 | Duran A Gutierrez G Zequeira R I | 2004 | International Journal of Production Economics2004，87，2： | 1 |
| 8 | Growth and antrum formation of bovine preantral follicles in long-term culture in vitro 显示文摘 | Gutierrez C G Ralph J R Telfer E E | 2000 | Biol Reprod2000，62，： | 1 |
| 9 | An algorithm for temperature-dependent growth rate simulation显示文摘 | STINNER R E GUTIERREZ A P BUTLER G D | 1974 | Can Ent1974，106，1： | 1 |
| 10 | The challenge of predicting field performance of air injection projects based on laboratory and numerical modeling显示文摘 | Gutierrez D Moore R G Mehta S A | 2009 | Journal of Canadian Petroleum Tech- nology2009，48，4： | 1 |
| 11 | The European high-speed train network: predicted effects on accessibility patterns显示文摘 | GUTIERREZ J GONZ~LEZ R G6MEZ G | 1996 | Journal of Transport Geography1996，4，4： | 1 |
| 12 | A random ized blinded clinical trial of two antivenoms,prepared by caprylic acid or ammonium sulphate fractionation of IgG,in Bothrop and Porthidium snake bites in Colombia:correlation between safety and biochem ical characteristics of antivenoms显示文摘 | Gutierrez J M Rojas G etal | 1999 | Toxicon1999，37，6： | 1 |
| 13 | Arandomized blinded clinical trial of two antivenoms,prepared by cap rylic acid or ammonium sulphate fractionation of IgG,in Bothrop and Porthidium snake bites in Colombia:correlation between safety and biochemical characteris2tics of antivenoms显示文摘 | Otero R Gutierrez J M Rojas G | 1999 | Toxicon1999，37，6： | 1 |
| 14 | Effects of nitrite concentration and exposure time on sulfide and methane production in sewer systems 显示文摘 | Jiang G M Gutierrez O Sharma K R | 2010 | Water Research2010，44，14： | 1 |
| 15 | Stimulation of bone formation in vitro and in rodents by statins显示文摘 | Mundy G Garrett R Harris S Chan J Chen D Rossini G Boyce B Zhao M Gutierrez G | | 0，，5446： | 1 |
| 16 | Development of a long-term bovine granulosa cell culture system:induction and maintenance of estradiol production, response to follicle-stimulating hormone,and morphological characteristics 显示文摘 | Gutierrez C G Campbell B K Webb R | 1997 | Biol Reprod1997，56，： | 1 |
| 17 | The European high - speed train network: Predicted effects on accessibility patterns 显示文摘 | Gutierrez J Gonzale R Gomez G | 1996 | Journal of Transport Geography1996，4，4： | 1 |
| 18 | Effects of nitrite con- centration and exposure time on sulfide and methane production in sewer systems显示文摘 | Jiang G M Gutierrez O Sharma K R | 2010 | Water Research2010，44，14： | 1 |
| 19 | High-performance thin-lay- er chromatography-bioautography for multiple antibiotic residues in cowls milk显示文摘 | Ramirez A Gutierrez R Diaz G | 2003 | Journal of Chromatography B2003，784，2： | 1 |
| 20 | Integrated process design and control via global optimization: a wastewater treatment plant case study 显示文摘 | Moles C G Gutierrez G Alonso A A Banga J R | 2003 | Chemical Engineering Research and Design2003，81，5： | 1 |
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