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| 1 | Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer显示文摘Angiogenesis,从先存在的新血容器的形成 vasculature,为许多生理的过程,和异常 angiogenesis 是必要的贡献一些最流行的人的疾病,包括癌症。Angiogenesis 被在 pro-angiogenic 和 anti-angiogenic 信号之间的精细的平衡控制。当发信号的 pro-angiogenic 广泛地被调查了时,怎么发展地调整了,自然地发生的 anti-angiogenic 分子阻止过多的生长脉管并且淋巴管仍然糟糕被理解。在这评论,我们总结上的当前的知识 semaphorins 和他们的受体, plexins 和 neuropilins,控制正常和病理学的 angiogenesis,与在脉管、淋巴的 endothelial 房间表明电路的调整 semaphorin 的 anti-angiogenic 上的一个重音。信息的这新兴的身体可以负担得起机会开发新奇 anti-angiogenic 治疗学的策略。 | Atsuko Sakurai Colleen Doci J Silvio Gutkind | 2012 | Cell Research2012，22，1： | 15 |
| 2 | Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance显示文摘Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in OSCC.Methods: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib response.Results: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar concentrations.Consistently, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in mice.Conclusions: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies. | Nur Syafinaz Zainal Bernard Kok Bang Lee Zheng Wei Wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong | 2019 | Cancer Biology & Medicine2019，16，2： | 3 |
| 3 | Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma irradiation and bleomycin is p53 independent显示文摘 | Patel V Ensley J F Gutkind J S | 2000 | Int J Cancer2000，88，5： | 1 |
| 4 | Hypoxia-induced energy stress inhibits the roTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma 显示文摘 | Schneider A Younis RH Gutkind JS | 2008 | Neoplasia2008，10，11： | 1 |
| 5 | E-cadherin and Hakai:signalling,remodeling or destruction?显示文摘 | Pece S Gutkind JS | 2002 | Nat Cell Biol2002，4，4： | 1 |
| 6 | First class a carbapenemase isolated from enterobacteriaceae in Argentina 显示文摘 | Radice M Power P Gutkind G | 2004 | Antimicrob Agents Chemother2004，48，3： | 1 |
| 7 | Detection and genetic characterization of 显示文摘 | FERNANDEZ-CANIGIA L CEJAS D GUTKIND G | 2015 | Anaerobe2015，33，： | 1 |
| 8 | VEGF controls endothelial-cell per- meability by promoting the beta-arrestin-dependent endocy- tosis of VE-cadherin显示文摘 | Gavard J Gutkind JS | 2006 | Nat Cell Biol2006，8，11： | 1 |
| 9 | Angiopoietin-1 prevents VEGF-induce endothelial permeability by sequestering Src through mDia显示文摘 | Gavard J Patel V Gutkind J S | 2008 | Dev Cell2008，14，1： | 1 |
| 10 | Semaphorin 4D/plexin-B1 induces endothelial cell migration through the activation of PYK2, Sre, and the phosphatidylinositol 3-kinase-Akt pathway 显示文摘 | Basile J R Afkhami T Gutkind J S | 2005 | Mol Cell Biol2005，25，16： | 1 |
| 11 | Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors显示文摘 | Miyamoto S Teramoto H Gutkind JS | 1996 | J Cell Biol1996，135，： | 1 |
| 12 | The semaphorin receptor plexin-B1 signals through a direct interaction with the Rhospecific nucleotide exchange factor, LARG 显示文摘 | Aurandt J Vikis H G Gutkind J S | 2002 | Proc Natl Acad Sci U S A2002，99，12： | 1 |
| 13 | CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcll0/ Maltl) complex显示文摘 | Martin D Galisteo R Gutkind JS | 2009 | J Biol Chem2009，284，10： | 1 |
| 14 | Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of AKT and ERK, and endothelial cell motility 显示文摘 | Basile J R Gavard J Gutkind J S | 2007 | J Biol Chem2007，282，34： | 1 |
| 15 | G-protein-coupled receptors and signaling networks: emerging paradigms显示文摘 | Marinissen MJ Gutkind JS | 2001 | Trends Pharmacol Sci2001，22，7： | 1 |
| 16 | VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadher- in 显示文摘 | Gavard J Gutkind JS | 2006 | Nat Cell Biol2006，8，11： | 1 |
| 17 | C-protein-coupled receptors and cancer 显示文摘 | Dorsam RT Gutkind JS | 2007 | Nat Rev Cancer2007，7，2： | 1 |
| 18 | RGS-containing RhoGEFs:the missing link between transforming G pro- teins and Rho显示文摘 | Fukuhara S Chikumi H Gutkind JS | 2001 | Oncogene2001，20，： | 1 |
| 19 | G-protein-coupled receptors and signaling networks:emerging paradigms显示文摘 | Marinissen M J Gutkind J S | 2001 | Trends in Pharmacological Sciences2001，22，7： | 1 |
| 20 | G-protein-coupled receptors andcancer显示文摘 | Dorsam RT Gutkind JS | 2007 | Nat Rev Cancer2007，7，： | 1 |
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