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| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Autoantibodies against MMP-7 as a novel diagnostic biomarker in esophageal squamous cell carcinoma显示文摘AIM: To evaluate the diagnostic values of serum autoantibodies against matrix metalloproteinase-7 (MMP-7) in patients with esophageal squamous cell carcinoma (ESCC). METHODS: The MMP-7 cDNA was cloned from ESCC tissues, and MMP-7 was expressed and purified from a prokaryotic system. MMP-7 autoantibodies were then measured in sera from 50 patients with primary ESCC and 58 risk-matched controls, using a reverse capture enzyme-linked immunosorbent assay (ELISA) in which autoantibodies to MMP-7 bound to the purified MMP-7 proteins. In addition, MMP-7 autoantibody levels in sera from 38 gastric cancer patients and from control serum samples were also tested. RESULTS: The optimum conditions for recombinant MMP-7 protein expression were determined as 0.04 mmol/L Isopropyl-β-D-Thiogalactopyranoside (IPTG) induction at 37℃ for four hours. The levels of serum autoantibodies against MMP-7 were significantly higher in patients with ESCC than in the matched-control samples (OD450 = 1.69 ± 0.08 vs OD450 = 1.55 ± 0.10, P < 0.001). The area under the receiver operating characteristic (ROC) curve was 0.87. The sensitivity and specificity for detection of ESCC were 78.0% and 81.0%, respectively, when the OD450 value was greater than 1.65. Although the levels of autoantibodies against MMP-7 were also significantly higher in patients with gastric cancer compared to control samples (OD450 = 1.62 ± 0.06 vs OD450 = 1.55 ± 0.10, P < 0.001), the diagnostic accuracy was less significant than in ESCC patients. The area of ROC curve was 0.75, whereas the sensitivity and specificity were 60.5% and 71.7%, respectively, when the cut-off value of OD450 was set at 1.60. CONCLUSION: Serum autoantibody levels of MMP-7 may be a good diagnostic biomarker for esophageal squamous cell carcinoma. | Jing-Hua Zhou Bin Zhang Kemp H Kernstine Li Zhong | 2011 | World Journal of Gastroenterology2011，17，10： | 8 |
| 3 | Abscisic acid perception and signaling: structura mechanisms and applications显示文摘不利环境条件是对农业产量的威胁因此在生计,健康和经济上施加全球效果。Abscisic 酸(骆驼毛的织物) 是调整不能生活的压力忍耐的重要植物荷尔蒙,从而允许种应付环境压力。以前,试图开发发信号的内在的骆驼毛的织物被困难在真正的骆驼毛的织物受体的鉴定妨碍了的机制的完全的理解。骆驼毛的织物受体的 PYR/PYL/RCAR 家庭的发现因此在克服这些障碍的努力代表了一个主要里程碑;从那以后,许多结构、功能的研究提供了详细卓见进从骆驼毛的织物感觉到骆驼毛的织物应答的基因抄写的激活的过程。这理解骆驼毛的织物感觉的机制并且发信号在压力抵抗的庄稼的遗传工程以及在新合成骆驼毛的织物收缩筋的设计用作最近的、初步的开发的基础,它为应力公差的农业改进保持大诺言。 | Ley Moy NG Karsten MELCHER Bin Tean TEH H Eric XU | 2014 | Acta Pharmacologica Sinica2014，35，5： | 4 |
| 4 | A molecular roadmap for induced multi-lineage transdifferentiation of fibroblasts by chemical combinations显示文摘 | Xiaoping Han Hao Yu Daosheng Huang Yang Xu Assieh Saadatpour Xia Li Lengmei Wang Jie Yu Luca Pinello Shujing Lai Mengmeng Jiang Xueying Tian Fen Zhang Yanhong Cen Yuko Fujiwara Wei Zhu Bin Zhou Tianhua Zhou Hongwei Ouyang Jianan Wang Guo-Cheng Yuan Shumin Duan Smart H Orkin Guoji Guo | 2017 | Cell Research2017，27，3： | 2 |
| 5 | 酵母硒对鹅生长性能、肉品品质、免疫力和抗氧化能力的影响显示文摘试验旨在研究酵母硒(YS)对鹅生长性能、肉品品质、免疫力和抗氧化能力的影响。试验选择体重相近1日龄鹅96只,随机分成4组,每组3个重复,每个重复8只鹅。63d试验期中,鹅YS喂0、0.10、0.30、0.50mg.kg-1(按硒计)。试验结果表明,酵母硒对鹅的生长性能无影响,但可显著提高鹅肉的品质。没有观察到胸肌灰分或脂肪含量的改变,但在0.1和0.5mg.kg-1组,观察到蛋白质含量的显著改善(P<0.05)。添加酵母硒可显著促进硒在肝脏、肾脏、胰腺和肌肉中的沉积(P<0.05或P<0.01),并且0.5mg.kg-1组增加最多。添加酵母硒可提高鹅器官和细胞的免疫力,但不会改变体液免疫。而且,日粮YS显著促进肌肉和肝脏的抗氧化能力(P<0.05),但是其效果因YS水平和器官而异。试验结果表明,日粮添加YS是改善鹅的肉品质、硒含量、免疫功能和抗氧化能力的一项有效措施。 | Baowei W Guoqing H Qiaoli W Bin Y 张树金 | 2012 | 饲料博览2012，，2： | 2 |
| 6 | Robust Audio Watermarking Using Perceptual Masking显示文摘 | Swanson M D Zhu Bin Tewfik A H | 1998 | Signal Processing1998，66，3： | 1 |
| 7 | Endogenous hydrogen sulfide regulates pulmonary artery collagen remodeling in rats with high pulmonary blood flow 显示文摘 | Li X Jin H Bin G | 2009 | Experimental Biol Med2009，234，5： | 1 |
| 8 | Seed rain dynamics reveals strong dispersal limitation,different reproductive strategies and responses to climate in a temperate forest in northeast China显示文摘 | LIB H HAO Z Q BIN Y | 2011 | Journal of Vegetation Science2011，23，2： | 1 |
| 9 | A novel DSP-based current-controlled PWM strategy for single phase grid connected inverters显示文摘 | Kojabadi H M Bin Yu Gadoura I A | 2006 | IEEE Transactions on Power Electronics2006，21，4： | 1 |
| 10 | CNC rake grinding for a taper ball end mill with torus shaped grinding wheel显示文摘 | Xiong F Bin H Z | 2003 | The International Journal of Advanced Manufacturing Technology2003，21，8： | 1 |
| 11 | Internet-based SCADA display system显示文摘 | QIU Bin GOOI H B | 2002 | IEEE Trans on Power Systems2002，15，1： | 1 |
| 12 | A novel DSP-based current-controlled PWM strategy for single phase grid connected inverters显示文摘 | Kojabadi H M Yu Bin Gadoura I A | 2006 | IEEE Transactions on Power Electronics2006，21，4： | 1 |
| 13 | Fault detection, identification and diagnosis using CUSUM based PCA显示文摘 | BIN SHAMS M A BUDMAN H M DUEVER T A | 2011 | Chemical Engineering Science2011，66，20： | 1 |
| 14 | Effects of colony-stimulating factors on neutrophil apoptosis:possible roles at inflammation site显示文摘 | Bin H Kozo Y | 1997 | Int J Hematol1997，66，： | 1 |
| 15 | Biomechanical study of artificial atlanto - odontoid joint 显示文摘 | Bin L Xijing H Chenguang Z | 2009 | Spine2009，18，： | 1 |
| 16 | 显示文摘 | Xi Y Ishikawa H Bin Y Z | 2004 | Carbon2004，42，： | 1 |
| 17 | Allocating the Costs of Reactive Power Purchased in an Ancillary Service Market by Modifieel Y-Bus Matrix Method显示文摘 | Wen C C Bin K C Chung H L | 2004 | IEEE Transaction on Power Systems2004，19，1： | 1 |
| 18 | Tin compounds and major trace met-al elements in organotin-poisoned Patient's urine and blood mea-sured by gas chromatography-flame photometric detector and induc-tively coupled plasma-mass spectrometry显示文摘 | Gui-bin J Qun-fang Z Bin H | | 0，，： | 1 |
| 19 | Surface Studies by Scanning Tunneling Microscopy显示文摘 | Binning G Rohrer H | 1982 | Phy Rev Lett1982，49，1： | 1 |
| 20 | Consumer Lifestyle ap- proach to US energy use and the related CO2 emissions显示文摘 | BIN S DOWLATABADI H | 2005 | Energy Policy2005，，33： | 1 |
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