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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | The N 400 event-related potential in aphasia显示文摘 | Kitade S Enai T Sei H | 1999 | J Med Invest1999，46，12： | 1 |
| 3 | A new linear programming method for weights generation and group decision making in the analytic hierarchy process显示文摘 | Seyed S H Hamidreza N Abas H | 2009 | Group Decision and Negotiation2009，18，6： | 1 |
| 4 | Multi-product production quantity model with repair failure and partial backordering显示文摘 | ATA A T WEE H M SEYED J S | 2010 | Computers and Industrial Engineering2010，59，1： | 1 |
| 5 | Effects of Al-5Ti-IB and Al-5Zr master alloys on the structure, hardness and tensile properties of a highly alloyed aluminum alloy显示文摘 | SEYED E S H EMAMY M | 2010 | International Materials Re- views2010，31，： | 1 |
| 6 | An enhanced model for small-signal analysis of the phase-shifted full- bridge converter显示文摘 | Giulia D C Seyed A S Michael A H | 2014 | IEEE Transactions on Power Electron- ics2014，99，： | 1 |
| 7 | Reconstruction of Reflectance Spectra Using Weighted Principal Component Analysis显示文摘 | FARNAZ A SEYED A A SEYED H A | 2008 | Color Research & Application2008，33，5： | 1 |
| 8 | Atmospheric cor rosion of different steels in marine, rural and industri al environments 显示文摘 | Sei J O Cook D C Townsend H E | 1999 | Corrosion Science1999，，： | 1 |
| 9 | Review of flexible riser modeling and analysis techniques显示文摘 | Patel M H Seyed F b | 1995 | Engineering Structure1995，17，4： | 1 |
| 10 | A muhi product EOQ model with inflation, discount, and permissible delay in payments under shortage and limited warehouse space 显示文摘 | Seyed H R P Seyed T A N I3ehzad M V | 2014 | Production Manufacturing Research2014，，： | 1 |
| 11 | A DFT Study on the Effect of Hydrogen in Ethylene and Propylene Polymerization Using a Ti-Based Heterogeneous Ziegler-Natta Catalyst 显示文摘 | Naeimeh B L Mehdi N H Seyed A M | 2012 | J OrganometChem2012，719，11： | 1 |
| 12 | Is serum vitamin D levels associated with disability in patients with newly diagnosed multiple sclerosis 显示文摘 | Hatamian H Bidabadi E Seyed SSM | 2013 | Iran J Nenro12013，12，2： | 1 |
| 13 | Internal flow-induced behavior of flexible risers显示文摘 | Patel M H Seyed F B | 1989 | Engineering Structures1989，11，4： | 1 |
| 14 | Developing two multi-objective evolutionary algorithms for the multi-objective flexible job shop scheduling problem 显示文摘 | Seyed H A Rahmat M Zandieh M Y | 2013 | The International Journal of Advanced Manufacturing Technology2013，64，5： | 1 |
| 15 | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin显示文摘 | Liou A P Lu XP Sei Y Zhao XL Pechhold S Carrero R J Raybould H E Wank S | | 0，，03： | 1 |
| 16 | Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives显示文摘 | Eun J O Kitae P Ki S K Jiseok K Jeong A Yang Ji H K Min Y L Allan S H Sei K H | 2010 | Journal of Controlled Release2010，141，1： | 1 |
| 17 | Production of single cell protein from natural gas:Parameter optimization and RNA evaluation显示文摘 | Fatemeh Y Solmaz H Seyed A S | 2005 | Iranian Journal of Biotechnology2005，3，4： | 1 |
| 18 | Antioxidant defense systems:The role of carotenoids,tocopherols,and thiols显示文摘 | Mascio P Di Murphy M E Seis H | 1991 | American Journal of Clinical Nutrition1991，53，： | 1 |
| 19 | Biochemistry of oxidative stress 显示文摘 | Seis H | 1986 | Angew Chem Int Ed Engl1986，25，： | 1 |
| 20 | Comparison of different control strategies in GA-based optimized UPFC controller in electric power systems显示文摘 | Seyed A T Reza H Majid N | 2008 | American Journal of Engineering and Applied Sciences 12008，，1： | 1 |
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