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| 1 | 采用动态推-拉技术增强动脉瘤分流器的导流作用:一项实验和模型研究显示文摘目的 神经血管分流器是治疗颅内动脉瘤的一种有弹性的、纵横交错的网状支架。本研究采用动态推-拉技术调节动脉瘤瘤口分流器的网格密度,以便最大化其导流作用。通过自主研发的高保真虚拟支架计算机模型技术联合计算机流体动力学,探讨动态推-拉技术对特定动脉瘤病人血流动力学的影响。方法采用动态推-拉技术和不同长度的传送导线,将两个Pipeline分流器放置到两个相同侧壁的大脑前动脉动脉瘤模型中。然后数字模拟操作过程,并验证模拟的网格几何结构。通过调节放置在侧壁动脉瘤和基底动脉主干梭形动脉瘤(前期已放置分流器)的分流器,采用计算机流体动力学分析,评估血流动力学的具体变化。同时评估来源于临床病例样本的分流器网格的影像。 | Ma D Xiang J Choi H 周静 郭玉慧 | 2014 | 中国微侵袭神经外科杂志2014，19，6： | 12 |
| 2 | Adjunctive aripiprazole for antipsychotic-related hyperprolactinaemia in patients with first-episode schizophrenia:a metaanalysis显示文摘Background Hyperprolactinaemia is a common antipsychotic(AP)-induced adverse effect,particularly in female patients.Aims This meta-analysis examined the efficacy and safety of adjunctive aripiprazole in preventing AP-related hyperprolactinaemia in patients with first-episode schizophrenia.Methods PubMed,PsycINFO,EMBASE,Cochrane Library,WanFang and China Journal Net databases were searched to identify eligible randomised controlled trials(RCTs).Primary outcomes were the reductions of serum prolactin level and prolactin-related symptoms.Data were independently extracted by two reviewers and analysed using RevMan(V.5.3).Weighted/standardised mean differences(WMDs/SMDs)±95%Cis were reported.Results In the five RCTs(n=400),the adjunctive aripiprazole(n=197)and the control groups(n=203)with a mean of 11.2 weeks of treatment duration were compared.The aripiprazole group had a significantly lower endpoint serum prolactin level in all patients(five RCTs,n=385;WMD:-50.43 ng/mL(95%Cl:-75.05 to-25.81),p<0.00001;l2=99%),female patients(two RCTs,n=186;WMD:-22.58 ng/mL(95%Cl:-25.67 to-19.49),p<0.00001;l2=0%)and male patients(two RCTs,n=127;WMD:-68.80 ng/mL(95%Cl:-100.11 to-37.49),p<0.0001).In the sensitivity analysis for the endpoint serum prolactin level in all patients,the findings remained significant(p<0.00001;l2=96%).The aripiprazole group was s叩erior to the control group in improving negative symptoms as assessed by the Positive and Negative Syndrome Scale(three RCTs,n=213;SMD:-0.51(95%Cl:-0.79 to-0.24),p=0.0002;l2=0%).Adverse effects and discontinuation rates were similar between the two groups.Conclusions Adjunctive aripiprazole appears to be associated with reduced AP-induced hyperprolactinaemia and improved prolactin-related symptoms in first-episode schizophrenia.Further studies with large sample sizes are needed to confirm these findings. | Wei Zheng Dong-Bin Cai Xin-Hu Yang Wei Zheng Gabor S Ungvari Chee H Ng Zhan-Ming Shi Mei-Ling Hu Yu-Ping Ning Yu-Tao Xiang | 2019 | General Psychiatry2019，32，5： | 4 |
| 3 | Adjunctive Peony-Glycyrrhiza decoction for antipsychotic-induced hyperprolactinaemia:a meta-analysis of randomised controlled trials显示文摘Background Hyperprolactinaemia is a common adverse effect of antipsychotics(APs). The results of PeonyGlycyrrhiza decoction(PGD) as a potentially useful adjunctive treatment for hyperprolactinaemia are inconsistent.Aim This meta-analysis of randomised controlled trials(RCTs) examined the efficacy and safety of adjunctive PGD therapy for AP-induced hyperprolactinaemia.Methods English(PubMed, Embase, Cochrane Library,PsycINFO) and Chinese(Chinese National Knowledge Infrastructure, Wanfang Data) databases were systematically searched up to 10 June 2018. The inclusion criteria were based on PIC0 S一/^rticipants: adult patients with schizophrenia; Aitervention: PGD plus APs; Cbmparison: APs plus placebo or AP monotherapy;(Xjtcomes: efficacy and safety; Study design: RCTs. The weighted mean difference(WMD) and risk ratio(RR) along with their 95% CIs were calculated using Review Manager(RevMan) V.5.3 software.Results Five RCTs(n=450) were included and analysed.Two RCTs(n=140) were double-blind and four RCTs(n=409) reported ‘random' assignment with specific description. The PGD group showed a significantly lower serum prolactin level at endpoint than the control group(n=380, WMD:-32.69 ng/mL(95% Cl-41.66 to 23.72),/X0.00001, ^=97%). Similarly, the superiority of PGD over the control groups was also found in the improvement of hyperprolactinaemia-related symptoms. No difference was found in the improvement of psychiatric symptoms assessed by the Positive and Negative Syndrome Scale(n=403,WMD:-0.62(95% Cl-2.38 to 1.15), p=0.49, ^=0%). There were similar rates of all-cause discontinuation(n=330, RR0.93(95% Ci 0.63 to 1.37),/t=0.71, ^=0%) and adverse drug reactions between the two groups. According to the Grading of Recommendations Assessment, Development and Evaluation approach, the level of evidence of primary and secondary outcomes ranged from ‘very low'(14.3%),‘low'(42.8%),‘moderate'(14.3%),to ‘high,(28.6%>.Conclusions Current evidence supports the adjunctive use of PGD to suppress elevated prolactin and improve prolactininduced symptoms without significant adverse events in adult patients with AP-induced hyperprolactinaemia. Highquality RCTs with longer duration are needed to confirm these findings.Trial registration number 42016037017. | Wei Zheng Dong-Bin Cai Hai-Yan Li Yu-Jie Wu Chee H Ng Gabor S Ungvari Shan-Shan Xie Zhan-Ming Shi Xiao-Min Zhu Yu-Ping Ning Yu-Tao Xiang | 2018 | General Psychiatry2018，31，4： | 3 |
| 4 | Antipsychotic Medications in Major Depression and the Association with Treatment Satisfaction and Quality of Life: Findings of Three National Surveys on Use of Psychotropics in China Between 2002 and 2012显示文摘 | Yu-Xi Wang Yu-Tao Xiang Yun-Ai Su Qian Li Liang Shu Chee H Ng Gabor S Ungvari Helen FK Chiu Yu-Ping Nin Gao-Hua Wang Pei-Shen Bai Tao Li Li-Zhong Sun Jian-Guo Shi Xian-Sheng Chen Qi-Yi Mei Ke-Qing Li Xin Yu Tian-Mei Si | 2015 | Chinese Medical Journal2015，，14： | 2 |
| 5 | Annealing effects on electrical and optical properties of ZnO thin film samples deposited by radio frequency magnetron sputtering on GaAs(001) substrates显示文摘 | LIU H F CHUA S J HU G X GONG H XIANG N | 2007 | Journal of Applied Physics2007，102，6： | 1 |
| 6 | Gestational diabetes mellitus显示文摘 | Buchanan T A Xiang A H | 2005 | J Clin Invest2005，115，3： | 1 |
| 7 | A DNA vaccine targeting survivin combines apoptosis with suppression of angiogenesis in lung tumor eradication显示文摘 | Xiang R Mizutani N Luo Y Chiodoni C Zhou H Mizutani M | 2005 | Cancer Res2005，65，： | 1 |
| 8 | Regression of engineered myeloma cells secreting interferon-gamma-inducing factor is mediated by both CD4(+)/CD8(+)T and natural killer cells显示文摘 | Xiang J Chen Z Huang H | 2001 | Leuk Res2001，25，10： | 1 |
| 9 | Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC显示文摘 | QUAN C REN Y Q XIANG L H | 2010 | Nat Genet2010，42，7： | 1 |
| 10 | A novel high perf ormance RTM resin based on benzoxazine显示文摘 | Xiang H Ling H Wang J Song L Gu Y | 2005 | Polymer Composites2005，26，5： | 1 |
| 11 | SKP2/P27 expression Profile is correlated with epstein-Barr virus status in extranodal nasal-type natural Killer cell lymphoma显示文摘 | Xiang L M Zu L S Dan H | 2008 | Transl Res2008，151，6： | 1 |
| 12 | Evaluating the effectiveness of an emergency preparedness training programme for public health staff in China 显示文摘 | Wang C Wei S Xiang H | 2008 | Public Health2008，122，5： | 1 |
| 13 | Liquid chromatography-tandem mass/mass spec- trometry method for the quantification of rabeprazole in human plasma and application to a pharmacokinetic study显示文摘 | Yu L Deng H Xiang B | 2010 | Armeimittelforschung2010，60，5： | 1 |
| 14 | Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors 显示文摘 | Xiang H Fox JA Totpal K | 2002 | Oncogene2002，21，： | 1 |
| 15 | Slurry phase Fischer-Tropsch synthesis over manganese-promoted iron ultrafine particle catalyst显示文摘 | BAI L XIANG H W LI Y W HAN Y Z ZHONG B | 2002 | Fuel2002，81，1112： | 1 |
| 16 | Initial deposition mechanism of electroless nickel plating on magnesium alloys显示文摘 | Xiang Y H Hu W B Liu X K | 2001 | Trans IMF2001，79，1： | 1 |
| 17 | Simulation of stationary Gaussian stochastic wind velocity field显示文摘 | Ding Q S Zhu L D Xiang H F | 2006 | Wind and Structures2006，9，3： | 1 |
| 18 | Crystallization and preliminary crystallographic studies of a novel antifungal protein with five disulfide bridges from Eucommia ulmoides Oliver显示文摘 | XIANG Y HUANG R H LIU W | 2002 | Acta Crystallogr D Biol Crystallogr2002，58，： | 1 |
| 19 | Effects of ECAE process on microstructure and transformation behavior of TiNi shape memory alloy 显示文摘 | LI Z H XIANG C Q CHENG X H | 2006 | Materials and Design2006，27，4： | 1 |
| 20 | Crocetin inhibits leu?kocyte adherence to vascular endothelial cells induced by AGEs显示文摘 | XIANG M QIAN Z Y ZHOU C H | 2006 | J Ethnopharmacol2006，107，1： | 1 |
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