|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | MicroRNA signatures in chemotherapy resistant esophageal cancer cell lines显示文摘AIM:To investigate expression of microRNA(miRNA)and potential targets in chemotherapy resistant esoph-ageal cancer cell lines.METHODS:An in-vitro model of acquired chemotherapy resistance in esophageal adeno-(EAC)and squamous cell carcinoma(ESCC)cells was used,and microRNA expression profiles for cisplatin or 5-fluorouracil(5-FU)resistant variants vs chemotherapy sensitive controls were compared using microarray and quantitative real-time polymerase chain reaction(PCR).The expression of chemotherapy-relevant genes potentially targeted by the dysregulated microRNAs in the chemotherapy resistant variants was also evaluated.RESULTS:Chemotherapy resistant sublines were found to have specific miRNA signatures,and these miRNA signatures were different for the cisplatin vs 5-FU resistant cells from the same tumor cell line,and also for EAC vs ESCC cells with resistance to the same specific chemotherapy agent.Amongst others,miR-27b-3p,miR-193b-3p,miR-192-5p,miR-378 a-3p,miR-125a-5p and miR-18a-3p were dysregulated,consistent with negative posttranscriptional control of KRAS,TYMS,ABCC3,CBL-B and ERBB2 expression via these miRNAs.CONCLUSION:The current study supports the hypothesis that microRNA expression has an impact on chemotherapy resistance in esophageal cancer. | Richard Hummel Corina Sie David I Watson Tingting Wang Alfiya Ansar Michael Z Michael Mark Van der Hoek Joerg Haier Damian J Hussey | 2014 | World Journal of Gastroenterology2014，20，40： | 8 |
| 2 | PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow显示文摘 | Haier J Nicolson GL | 2002 | Oncogene2002，21，9： | 1 |
| 3 | PTEN regulates tumor cell adhesion of clon carcinoma cells under dynamic conditions of fluid flow显示文摘 | Haier J Nicolson GL | 2002 | Oncogen2002，21，9： | 1 |
| 4 | PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow显示文摘 | Haier J Nicolson GL | 2002 | Oncogene2002，21，9： | 1 |
| 5 | Integrins in cancer treatment显示文摘 | Eble JA Haier J | 2006 | Curr Cancer Drug Targets2006，6，2： | 1 |
| 6 | Time-dependent dephosphorylation through serine/threonine phosphatases is required for stable adhesion of highly and pooly metastatic HT-29 colon carcinoma cell lines to collagen显示文摘 | Haier J Nicoson GL | 2000 | Anticancer Res2000，20，4： | 1 |
| 7 | Different adhesion properties of highly and poorly metastatic HT-29 colon carcinoma cells with extracellular matrix components: role of integrin expression and cytoskeletal components显示文摘 | Haier J Nasralla M Nico|son GL | 1999 | Br J Cancer1999，80，12： | 1 |
| 8 | Integrins in cancer treatment显示文摘 | Eble J A Haier J | | 0，，： | 1 |
| 9 | MicroRNAs: predictors andmodifiers of chemo- and radiotherapy in different tumour types显示文摘 | Hummel R Hussey DJ Haier J | 2010 | Eur J Cancer2010，46，2： | 1 |
| 10 | Beta1-integrin-mediated dynamic adhesion of colon carcinoma cells to extracellular matrix under laminar flow显示文摘 | Haier J Nasralla MY Nicolson GL | 1999 | Clin Exp Metastasis1999，17，5： | 1 |
| 11 | Levels of homocysteine are increased in metabolic syndrome patients but are not associated with an increased cardiovascular risk,in contrast to patients without the metabolic syndrome显示文摘 | HAIER G R OELIHOEK J K VERHAAR M C | 2007 | Heart2007，93，： | 1 |
| 12 | Time-dependent dephosphorylation through serine/threonine phosphatases is required for stable adhesion of highly and poorly metastatic HT-29 colon carcinoma cell lines to collagen 显示文摘 | Haier J Nicolson GL | 2000 | Anticancer Res2000，20，： | 1 |
| 13 | Expression of MAGE-A cancer/testis antigens in esophageal squamous cell carcinomas显示文摘 | Haier J Owzcareck M Guller U | 2006 | Anticancer Res2006，26，3： | 1 |
| 14 | Multiple mycoplasmal infection detected in blood of patients with chronic fatigue syndrome and/or fibromyalgia 显示文摘 | Nasralla M Haier J Nicolson GL | 1999 | Eur J Clin Microbiol Infect Dis1999，18，12： | 1 |
| 15 | CXCR4 regulates tumor cell extravasation in vivo显示文摘 | Gassmann P Haier J Schltiter K | 2009 | Neoplasia2009，11，7： | 1 |
| 16 | MicroRNAs in brain tumors:a new diagnosfc and therapeutic perspective显示文摘 | Hummel R Maurer J Haier J | | 0，，03： | 1 |
| 17 | Detection of mycoplasmalinfections in blood of patients with rheumatoid arthritis显示文摘 | Haier J Nasralla M Franco AR | 1999 | Rheumatology (Oxford)1999，38，6： | 1 |
| 18 | CXCR4 regulates the early extravasation of metastatic tumor cells in vivo显示文摘 | Gassmann P Haier J Schlater K | 2009 | Neoplasia2009，11，7： | 1 |
| 19 | High frequency of systemic mycoplasmal infections in Gulf War veterans and civilians with anyotrophic lateral sclerosis(ALS) 显示文摘 | Nicolson GL Nasralla MY Haier J | 2002 | J Clin Neurosci2002，9，： | 1 |
| 20 | Investigation of serotonin type 4 receptor expression in human and non-human primate gastrointestinal samples显示文摘 | Mader R Kocher T Haier J | | 0，，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员