|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Single vs dual(en bloc) kidney transplants from donors ≤ 5 years of age: A single center experience显示文摘AIM: To compare outcomes between single and dual en bloc(EB) kidney transplants(KT) from small pediatric donors. METHODS: Monocentric nonprospective review of KTs from pediatric donors ≤ 5 years of age. Dual EB KT was defined as keeping both donor kidneys attached tothe inferior vena cava and aorta, which were then used as venous and arterial conduits for the subsequent transplant into a single recipient. Donor age was less useful than either donor weight or kidney size in decision-making for kidney utilization as kidneys from donors < 8 kg or kidneys < 6 cm in length were not transplanted. Post-transplant management strategies were standardized in all patients.RESULTS: From 2002-2015, 59 KTs were performed including 34 dual EB and 25 single KTs. Mean age of donors(17 mo vs 38 mo, P < 0.001), mean weight(11.0 kg vs 17.4 kg, P = 0.046) and male donors(50% vs 84%, P = 0.01) were lower in the dual EB compared to the single KT group, respectively. Mean cold ischemia time(21 h), kidney donor profile index(KDPI; 73% vs 62%) and levels of serum creatinine(SCr, 0.37 mg/d L vs 0.49 mg/d L, all P = NS) were comparable in the dual EB and single KT groups, respectively. Actuarial graft and patient survival rates at 5-years follow-up were comparable. There was one case of thrombosis resulting in graft loss in each group. Delayed graft function incidence(12% dual EB vs 20% single KT, P = NS) was slightly lower in dual EB KT recipients. Initial duration of hospital stay(mean 5.4 d vs 5.6 d) and the one-year incidences of acute rejection(6% vs 16%), operative complications(3% vs 4%), and major infection were comparable in the dual EB and single KT groups, respectively(all P = NS). Mean 12 mo SCr and abbreviated MDRD levels were 1.17 mg/d L vs 1.35 mg/d L and 72.5 m L/min per 1.73 m^2 vs 60.5 m L/min per 1.73 m^2(both P = NS) in the dual EB and single KT groups, respectively. CONCLUSION: By transplanting kidneys from young pediatric donors into adult recipients, one can effectively expand the limited donor pool and achieve excellent medium-term outcomes. | Yousef Al-Shraideh Umar Farooq Hany El-Hennawy Alan C Farney Amudha Palanisamy Jeffrey Rogers Giuseppe Orlando Muhammad Khan Amber Reeves-Daniel William Doares Scott Kaczmorski Michael D Gautreaux Samy S Iskandar Gloria Hairston Elizabeth Brim Margaret Mangus Robert J Stratta | 2016 | World Journal of Transplantation2016，6，1： | 3 |
| 2 | Sclerostin activity plays a key role in the negative effect of glucocorticoid signaling on osteoblast function in mice显示文摘Stress during prenatal development is correlated with detrimental cognitive and behavioral outcomes in offspring. However, the long-term impact of prenatal stress(PS) and disrupted glucocorticoid signaling on bone mass and strength is not understood. In contrast, the detrimental effect of lead(Pb) on skeletal health is well documented. As stress and Pb act on common biological targets via glucocorticoid signaling pathways and co-occur in the environment, this study first sought to assess the combined effect of stress and Pb on bone quality in association with alterations in glucocorticoid signaling. Bone parameters were evaluated using microCT, histomorphometry, and strength determination in 8-month-old male mouse offspring subjected to PS on gestational days 16 and 17, lifetime Pb exposure(100 p.p.m. Pb in drinking water), or to both. Pb reduced trabecular bone mass and, when combined with PS, Pb unmasked an exaggerated decrement in bone mass and tensile strength. Next, to characterize a mechanism of glucocorticoid effect on bone, prednisolone was implanted subcutaneously(controlled-release pellet, 5 mg·kg^(-1) per day) in 5-month-old mice that decreased osteoblastic activity and increased sclerostin and leptin levels. Furthermore, the synthetic glucocorticoid dexamethasone alters the anabolic Wnt signaling pathway. The Wnt pathway inhibitor sclerostin has several glucocorticoid response elements, and dexamethasone administration to osteoblastic cells induces sclerostin expression. Dexamethasone treatment of isolated bone marrow cells decreased bone nodule formation, whereas removal of sclerostin protected against this decrement in mineralization.Collectively, these findings suggest that bone loss associated with steroid-induced osteoporosis is a consequence of sclerostin-mediated restriction of Wnt signaling, which may mechanistically facilitate glucocorticoid toxicity in bone. | Eric E Beier Tzong-Jen Sheu Emily A Resseguie Masahiko Takahata Hani A Awad Deborah A Cory-Slechta J Edward Puzas | 2017 | Bone Research2017，5，2： | 3 |
| 3 | Evaluation of the safety and effectiveness of direct oral anticoagulants and low molecular weight heparin in gastrointestinal cancer-associated venous thromboembolism显示文摘BACKGROUND Gastrointestinal cancer(GICA)is associated with a higher incidence of venous thromboembolism(VTE)compared to other solid tumors,moreover,recurrent VTE and major bleeding(MB)complications during anticoagulation treatment have an associated increase rate.GICA-VTE remains a challenging clinical scenario with MB concerns for utilization of direct oral anticoagulants(DOAC),especially with active cancer therapies.AIM To evaluate patient risk factors,effectiveness(VTE)and safety(MB)of DOACs and low molecular weight heparin(LMWH)in patients with active GICA-VTE.METHODS A retrospective chart review of patients receiving DOACs and LMWH with GICA and symptomatic or incidental VTE treated at comprehensive cancer center from November 2013 to February 2017 was performed.Inclusion criteria included active GI cancer diagnosed at any stage or treatment+/-6 mo of VTE diagnosis,whom were prescribed 6 mo or more of DOACs or LMWH.The Chi-squared test was used for overall and the Fisher exact test for pairwise comparisons of the proportions of patients experiencing recurrent VTE and MB events.Odds ratios were used to compare the relative odds of the occurrence of the outcome given exposure to the risk factor.RESULTS A total of 144 patients were prescribed anticoagulation,in which 106 fulfilled inclusion criteria apixaban(27.3%),rivaroxaban(34.9%)and enoxaparin(37.7%),and 38 were excluded.Patients median age was 66.5 years at GICA diagnosis and 67 years at CAVTE event,with 62%males,80%Caucasian,70%stage IV,pancreatic cancer(40.5%),30%Khorana Score(≥3 points),and 43.5%on active chemotherapy.Sixty-four percent of patients completed anticoagulation therapy(range 1 to 43 mo).Recurrent VTE at 6 mo was noted in 7.5%(n=3),6.8%(n=2)and 2.7%(n=1)of patients on enoxaparin,apixaban and rivaroxaban,respectively(all P=NS).MB at 6 mo were 5%(n=2)for enoxaparin,6.8%(n=2)for apixaban and 21.6%(n=8)for rivaroxaban(overall P=0.048;vs LMWH P=0.0423;all other P=NS).Significant predictors of a primary or secondary outcome for all anticoagulation therapies included:Active systemic treatment(OR=5.1,95%CI:1.3-19.3),high Khorana Score[≥3 points](OR=5.5,95%CI:1.7-17.1),active smoker(OR=6.7,95%CI:2.1-21.0),pancreatic cancer(OR=6.8,95%CI:1.9-23.2),and stage IV disease(OR=9.9,95%CI:1.2-79.1).CONCLUSION Rivaroxaban compared to apixaban and enoxaparin had a significantly higher risk of MB on GICA-VTE patients with equivocal efficacy. | Alejandro Recio-Boiles Sumana Veeravelli Jessica Vondrak Hani M Babiker Aaron J Scott Rachna T Shroff Hitendra Patel Emad Elquza Ali McBride | 2019 | World Journal of Gastrointestinal Oncology2019，11，10： | 3 |
| 4 | Linezolid reduces length of stay and duration of intravenous treatment compared with vancomycin for complicated skin and soft tissue infections due to suspected or proven methicillin-resistant Staphylococcus aureus (MRSA) 显示文摘 | hani KM Weigeh J Li JZ | 2005 | Int J Antimicrob Agents2005，26，： | 1 |
| 5 | Expanded Polytetrafluoroethylene(GoreTex Surgical Membrane)is superior to oxidized regenerated cellulose(Interceed TC7)in preventing adhension显示文摘 | Hany AF Hesla J Hurst BS Kettel LM Murphy AA Rock JK Rove G Schlaft WD | 1995 | Fertil and Steril1995，55，： | 1 |
| 6 | On the use of neural networks to evaluate groundwater levels in fractured media显示文摘 | Lallahem S Maniaa J Hani A Najjar Y | 2005 | Journal of Hydrology2005，307，： | 1 |
| 7 | GRHL 2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28显示文摘 | HanY Mu Y Li X Xu P Tong J Liu Z | 2011 | Hum Mol Genet2011，20，： | 1 |
| 8 | On the use of neural networks to evaluate groundwater levels in fractured media显示文摘 | ALLAHEM S MANIAA J HANI A | 2005 | Journal of Hydrology2005，307，： | 1 |
| 9 | Effects of maternal exposure to a reconstituted mixture of polyehlorinated biphenyls on sex-dependent behaviors and steroid hormone concentrations in rats: dose-response relationship显示文摘 | Kaya H Hany J Fastabend A | 2002 | Toxicol Appl Pharmacol2002，178，： | 1 |
| 10 | Current-mode triple and quadruple langmuir probe methods with applications to flowing pulsed plasmas 显示文摘 | Gatsonis N A Byrne L T Zwahlen J C Pencil E J and Kamhawi Hani | 2004 | IEEE Transactions on Plasma Science2004，32，5： | 1 |
| 11 | Interfractional variation in position of the uterus during radical radiotherapy for cervical cancer 显示文摘 | Huh S J ParkW HanY | 2004 | Radiother Oncol2004，71，1： | 1 |
| 12 | Gasoline composition determined by1H NMR spectroscopy显示文摘 | BURRI J CROCKETT R HANY R | 2004 | Fuel2004，83，2： | 1 |
| 13 | Synthesis and Design of Superhard Materials 显示文摘 | Hanies J Loger J M Bocquillon G | 2001 | Annu Rev Mater Res2001，31，： | 1 |
| 14 | Roles of P300, a transcriptional coactivator in signalling of TGF-beta显示文摘 | Nishihara A Hani J Okamoto N | 1998 | Genes Cells1998，3，： | 1 |
| 15 | Muscle spindles are concentrated in the superior vocalis subcompartment of the human thyroarytenoid muscles显示文摘 | Sanders L HanY Wang J | 1998 | J Voice1998，12，1： | 1 |
| 16 | Interfractional variation in position of the uterus during radical radiotherapy for cervical cancer 显示文摘 | Huh S J ParkW HanY | 2004 | Radiother Oncol2004，71，1： | 1 |
| 17 | The Nematode Resistance Allele at the rhg1 Locus Alters the Proteome and Primary Metabolism of Soybean Roots1[W][OA]显示文摘 | Afzal Ahmed J Natarajan Aparna Saini Navinder Iqbal M Javed Geisler Matt El Shemy Hany A Mungur Rajsree Willmitzer Lothar Lightfoot David A | 2009 | Plant Physiology2009，，3： | 1 |
| 18 | Solving coelution problems on a semctic--liquid crystalline polysiloxane capillary column for the determination of priority polycyclic zromatic hydrocarbons in environmental samples显示文摘 | Berset J D Holzer R Hani H | 1998 | Journal of Chromatography A1998，823，12： | 1 |
| 19 | Fundamentals of dry powder blending for metal matrix composites显示文摘 | Gerald P J Jayashree L Hani H | 1993 | The International Journal of Powder Metallurgy1993，29，4： | 1 |
| 20 | Unusual causes of mechanical small bowel obstruction 显示文摘 | SHATNAWI N J BANI HANI K E | 2005 | Saudi Med J2005，26，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员