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| 1 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 2 | Aetive demethvlation of paternal genome in mammalian zygotes显示文摘 | Hany A Yusuke Y Shinichi H | | 0，，： | 1 |
| 3 | Weed seedbank response to tillage and crop rotation in a semi-arid environment显示文摘 | Hani G Nawal A H | 2005 | Soil and Tillage Research2005，84，2： | 1 |
| 4 | Surface binding of aflatoxin B1 by lactic acid bacteria显示文摘 | CAROLYN A H HANI S E PASI E K | 2001 | Applied and Environmental Microbiology2001，67，7： | 1 |
| 5 | The oxidation of NdFeB magnets显示文摘 | LI Y EVANS H E HANIS I R | 2003 | Oxidation of Metals2003，59，： | 1 |
| 6 | Effects of maternal exposure to a reconstituted mixture of polyehlorinated biphenyls on sex-dependent behaviors and steroid hormone concentrations in rats: dose-response relationship显示文摘 | Kaya H Hany J Fastabend A | 2002 | Toxicol Appl Pharmacol2002，178，： | 1 |
| 7 | Genomewide search for type 2 diabetes-susceptibility genes in French whites:evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24显示文摘 | Vionnet N Hani El H Dupont S | 2000 | Am J Hum Genet2000，67，6： | 1 |
| 8 | Non-suppurative myocarditis in piglets associated with porcine parvovirus infection显示文摘 | Bolt D M Hani H Muller E | 1997 | J CompPathol1997，117，2： | 1 |
| 9 | A two-dimensional problem for a half-space in magneto thermoelasticity with thermal relaxation显示文摘 | Hany H Sherie Kamal A Hekmy | 2002 | Int J Eng Sci2002，，40： | 1 |
| 10 | Mechanisms of mitochondrial dysfunction and energy defficiency in Alzheimer's disease 显示文摘 | Hani A William H Frey II | 2007 | Mitochondrion2007，7，1： | 1 |
| 11 | Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians 显示文摘 | Hani E H Clement K Velho G | 1997 | Diabetes1997，46，： | 1 |
| 12 | A Case Study on Evaluations of Improvements Implemented by WISE Projects in the Philippines显示文摘 | Takeyama H hany T Taehi N | 2006 | Ind Health2006，44，： | 1 |
| 13 | Genomewide search for type 2 diabetes-susceptibility genes in French whites:evi-dence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24显示文摘 | Vionnet N Hani El H Dupont S | 2000 | Am J Hum Genet2000，67，6： | 1 |
| 14 | PET diagnostic accuracy improvement with in line PET-CT system: initial results显示文摘 | HANY T F STEINERT H C GOERRES G W | 2002 | Radiology2002，225，2： | 1 |
| 15 | Genome wide searchfor type 2 diabetes-susceptibility genes in French whites: evidence for anovel susceptibility locus for early-onset diabetes on chromosome 3q27-qterand independent replication of a type 2 diabetes locus on chromosome 1q21-q24显示文摘 | Vionnet N Hani E H Dupont S | 2000 | Am J Hum Genet2000，672，： | 1 |
| 16 | Influence of drug-eluting stent on inflammation during restenosis in a porcine coronary model显示文摘 | Ge H Zhou Y Hanying M | 2010 | Acta Cardiol2010，65，： | 1 |
| 17 | Non-suppurative myocarditis in piglets associated with porcine parvovirus infec- tion显示文摘 | BOLT D M HANI H MULLER E | 1997 | J Comp Pathol1997，117，2： | 1 |
| 18 | Catt~ic acid phenethyl a ester, 5 - lipoxygenase enzyme inhibitor alleviates diabetic atherosclerotic manitestations:Effect on vascular reaetivity and stiffness显示文摘 | Noura A H Hany M E B | 2014 | Chemico-Biological Interactions2014，，213： | 1 |
| 19 | Non-suppurative myocard it is in piglets associated with porcine parvovirus infection显示文摘 | Bolt D M Hani H Muller E | 1997 | J CompPathol1997，117，2： | 1 |
| 20 | A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q,proximal to the phosphoenolpyruvate carboxykinase gene显示文摘 | Zouali H Hani EH A Philippi | 1997 | Human Molecular Genetics1997，6，9： | 1 |
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