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53篇 您的检索式：作者名="HARTOG J M"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	Application of the HACCP concept to improve the safety of street foods显示文摘	Hartog B J Stoots J A M	1992	Food Lab News1992，8，2：	1
3	If You Are So Smart, Why Aren't You An Entrepreneur Returns to Cognitive and Social Ability: Entrepreneurs Versus Employees显示文摘	Hartog J Van Praag M Van Der Sluis J	2010	Journal of Economics & Management Strategy2010，19，4：	1
4	Molecular identification of the api- cal Ca2+channel in 1,25-dihydroxyvitamin Dz-respon- sive epithelia 显示文摘	HOENDEROP J G VAN DER KEMP A W C M HARTOG A	1999	The Journal of Biological Chemis- try1999，274，13：	1
5	Rela-tionship between allergic rhinitis,disturbed cognitive functions and psychological well being显示文摘	KREMER B DEN HARTOG H M JOLLES J	2002	Clin Exp Allergy2002，32，：	1
6	The Arabidopsis somatic embryogenesis receptor kinase 1 gene is expressed in developing ovules and embryos and enhances embryogenic competence in culture显示文摘	Hecht V Vielle-Calzada J P Hartog M V	2001	Plant Physiol2001，127，：	1
7	Air pollution from traffic in city districts near major motorways显示文摘	ROORDA-KNAPE M C JANSSEN N A H HARTOG J J D	1998	Atmos Environ1998，32，11：	1
8	The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1 gene is expressed in developing ovules and embryos and enhances embryogenic competence in cuhure显示文摘	Hecht V Vielle-Calzada J P Hartog M V et ol	2001	Plant Physiology2001，127，3：	1
9	Motor ve hicle exhaust and chronic respiratory symptoms in children liv- ing near freeways 显示文摘	VAN VLIET P KNAPE M DE HARTOG J	1997	Environmental Research1997，74，2：	1
10	Metabolic engineering of a xylose-isomerase-expressing Saccharomyces cerevisiae strain for rapid anaerobic xylose fermentation显示文摘	Kuyper M Hartog M M P Toirkens M J	2005	FEMS Yeast Res2005，5，45：	1
11	The effect of improvement in diabetic control on plasma and whole blood viscosity显示文摘	Paisey R Havkness J Hartog M	1980	Diabetologia1980，18，3：	1
12	Relationship between different size classes of particulate matter and meteorology in three European cities显示文摘	Hartog J J Gerard H Aadu M	2005	Journal of Environment Monitoring2005，7，30：	1
13	The Arabidopsis somatic embryogenesis receptor kinase 1 gene is expressed in developing ovules and embryos and enhances embryogenic competence in culture显示文摘	Hecht V Vielle-Calzada J P Hartog M V	2001	Plant Physiology2001，127，3：	1
14	Erythritol is a sweet antioxidant 显示文摘	CERTJAN J M DEN HARTOG AGNES w	2010	Nutrition2010，26，4：	1
15	Tissue advanced glycation end products are associated with diastolic function and aerobic exercise capacity in diabetic heart failure patients显示文摘	Willemsen S Hartog J W Hummel Y M	2011	Eur J Heart Fail2011，13，1：	1
16	Fermented wheat in liquid diets: effect on gastrointestinal characteristics in weanling piglets 显示文摘	Schohen R H J van der Peet-Schwering C M C den Hartog L A	2002	Journal of Animal Science2002，80，5：	1
17	Improved la- boratory trasition probabilities for Pt I and application to the platinum abundance of BD + 17~ 3248 and the sun 显示文摘	Den Hartog E A Herd M T Lawler J E	2005	The Astrophysical Journal2005，619，：	1
18	Erythritol is a sweet antioxidant显示文摘	DEN HARTOG G J M BOOTS A W ADAM-PERROT A	2010	Nutrition2010，26，4：	1
19	The New Dutch Kidney Test- Practical evaluation显示文摘	Broex N J den Hartog J M Nouws J F	1988	Tijdschr Diergeneeskd Dutch1988，113，5：	1
20	The insulinlike growth factor 1 receptor in cancer old focus, newfuture显示文摘	HARTOG H WESSELING J BOEZEN H M	2007	Eur J Cancer2007，43，：	1

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