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| 1 | Six Minute Walk Test to assess functional capacity in chronic liver disease patients显示文摘AIM: To examine the utility of Six Minute Walk Test (6MWT) in patients with chronic liver disease (CLD). METHODS: Two hundred and fifty subjects between the ages of 18 and 80 (mean 47) years performed 6MWT and the Six Minute Walk Distance (6MWD) was measured. RESULTS: The subjects were categorized into four groups. Group A (n = 45) healthy subjects (control); group B (n = 49) chronic hepatitis B patients; group C (n = 54) chronic hepatitis C patients; group D (n = 98) liver cirrhosis patients. The four groups differed in terms of 6MWDs (P < 0.001). The longest distance walked was 421 ± 47 m by group A, then group B (390 ± 53 m), group C (357 ± 72 m) and group D (306 ± 111 m). The 6MWD correlated with age (r = -0.482, P < 0.01), hemoglobin (r = +0.373, P < 0.001) and albumin (r = +0.311, P < 0.001) levels. The Child-Pugh classification was negatively correlated with the 6MWD in cirrhosis (group D) patients (r = -0.328, P < 0.01). At the end of a 12 mo follow-up period, 15 of the 98 cirrhosis patients had died from disease complications. The 6MWD for the surviving cirrhotic patients was longer than for non-survivors (317 ± 101 vs 245 ± 145 m, P = 0.021; 95% CI 11-132). The 6MWD was found to be an independent predictor of survival (P = 0.024). CONCLUSION: 6MWT is a useful tool for assessing physical function in CLD patients. We suggest that 6MWD may serve as a prognostic indicator in patients with liver cirrhosis. | Hatem F Alameri Faisal M Sanai Manal Al Dukhayil Nahla A Azzam Khalid A Al-Swat Ahmad S Hersi Ayman A Abdo | 2007 | World Journal of Gastroenterology2007，13，29： | 5 |
| 2 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 3 | Primary culture of human aterial myocytes is associated with the appearance of structural and functional characteristics of immature myocardium显示文摘 | Benardeau A Hatem SN Rueche-Mwtin C | 1997 | J Mol Cell cardiol1997，29，： | 1 |
| 4 | Accuracy of dual-source CT coronary angiography: First experience in a high pre-test probability population without heart rate control 显示文摘 | Hans S Hatem A Andr6 P | 2006 | Eur Radiol2006，16，12： | 1 |
| 5 | Primary culture of human atrial myocytes is associated with the appearance of structural and functional characteristics of immature myocardium显示文摘 | Benardeau A Hatem S N Ruckel - Martin C | 1997 | J Mol Cell Cardiol1997，29，6： | 1 |
| 6 | The voltage-independent B-type Ca2 + channel modulates apoptosis of cardiac myocytes 显示文摘 | HENAFF M ANTOINE S MERCADIER J J COULOMBE A HATEM SN | 2002 | FASEB J2002，15，1： | 1 |
| 7 | Artificial floor technique used for the repair of furcation perforations:A microleakage study显示文摘 | Hatem A Ali I | 1998 | J Ended1998，24，1： | 1 |
| 8 | Accuracy of dual-source CT coronary angiography:First experience in a high pre-test probability population without heart rate control显示文摘 | Hans S Hatem A André P | 2006 | Eur Radiol2006，16，12： | 1 |
| 9 | Accuracy of MSCT coronary angiography with 64-slice technology: first experience 显示文摘 | Sebastian L Hatem A Andre P | 2005 | European Heart Journal2005，26，3： | 1 |
| 10 | Specificities of atrial e|ectrophysiology: Clues toa better understanding of cardiac function and the mechanismsof arrhythmias显示文摘 | Hatem S N Coulombe A Balse E | 2010 | J Mol Cell Cardiol2010，48，1： | 1 |
| 11 | Somatotopic organiza- tion of the analgesic effects of motor cortex rTMS in neuro- pathic pain 显示文摘 | Lefaucheur JR Hatem S Nineb A | 2006 | Neurology2006，67，11： | 1 |
| 12 | Primary culture of human atrial myocytes is associated with the appearance of structural and functional characteristics of immature myocardium显示文摘 | BENARDEAU A HATEM S N RUCKER-MARTIN C | 1997 | J Mol Cell Cardiol1997，29，5： | 1 |
| 13 | Primary culture of human atrial myocytes is associated with the appearance of structural and functional characteristics of immature myocardium显示文摘 | BENARDEAU A HATEM S N RUCKER-MARTIN C | 1997 | J Mol Cell Cardiol1997，29，： | 1 |
| 14 | Primary culture of human aterial myocytes is associated with the appearance of structural and functional characteristics of immature myocardium显示文摘 | Benardeau A Hatem SN Ruecker-Martin C | | 0，，： | 1 |
| 15 | Interactive MR imaging guided biopsy and aspiration with a modified clinical C-arm system显示文摘 | Lewin J S Petersilge C A Hatem S F | 1998 | AJR Am J Roentgenol1998，170，6： | 1 |
| 16 | Primary culture of human atrial myocytes is associated with the appearance of structural and functional Characteristics of Immature Myocardium 显示文摘 | Benardeau A Hatem S N Rucker-Martin C | 1997 | J Mol Cell Cardiol1997，29，5： | 1 |
| 17 | A couracy of dual-source CT coronary angiography,First experience in a pre-test probab ility population w ithout heart rate control显示文摘 | Hans S Hatem A Anere P | 2006 | Eur Radiol2006，16，12： | 1 |
| 18 | Primary culture of human atrial myocytes is associated with the appearance of structural and functional characteristics of immature myocardium显示文摘 | Benardeau A Hatem SN Rucker-Martin C | 1997 | J Mol Cell Cardiol1997，29，： | 1 |
| 19 | Bayesian surviral estimation of Pareto distribution of the second kind based on failure-censored data 显示文摘 | Hatem A Howlader and Anwar M Hossain | 2002 | Computational Statistics & Data Analysis2002，38，： | 1 |
| 20 | Primary culture of human atrial myocytes is associated with the appearance of structural and functional characteristics of immature myocardium显示文摘 | Benardeau A Hatem SN Rucker-Martin C | 1997 | J Mol Cell Cardiol1997，29，5： | 1 |
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