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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 3 | Size ratio correlates withintracranial aneurysm rupture status:a prospective study显示文摘 | Rahman M Smietana J Hauck E | 2010 | Stroke2010，41，5： | 1 |
| 4 | Translocation of two glucose transporters in heart: effects of rotenone, uncouplers,workload, palmitate, insulin and anoxia显示文摘 | WHEELER T J FELL R D HAUCK M A | 1994 | Biochim Biophys Acta1994，1196，2： | 1 |
| 5 | Determining nutrient export coefficients and source loading in stream monitoring data 显示文摘 | MCFARLAND A M HAUCK K M | 2001 | Journal of the American Water Resources Association2001，37，1： | 1 |
| 6 | Environmental benefits and economic costs of manure incorporation on dairy waste application fields显示文摘 | Osei E Gassman P W Hauck L M | 2003 | Journal of Environmental Management2003，68，： | 1 |
| 7 | Coastal and fisheries co-management in South Africa: an overview and analysis显示文摘 | Hauck M Sowman M | 2001 | Marine Policy2001，25，3： | 1 |
| 8 | Determining nutrient export coefficients and source loading uncertainty using in-stream monitoring data 显示文摘 | Mcfarland A M Hauck L M | 2001 | J Ame Water Resources Assoc2001，37，1： | 1 |
| 9 | On finite groups with nilpotent Sylow normalizers显示文摘 | Bianchi M Mauri A G B Hauck P | 1986 | Arch Math1986，47，： | 1 |
| 10 | P21cip controls proliferating cell nuclear antigen level in adult cardiomyocytes显示文摘 | Engel FB Hauck L Boehm M | 2003 | Mol Cell Biol2003，23，2： | 1 |
| 11 | Ferrous iron oxidation by denitrifying bacteria in profundal sediments of a deep lake (Lake Constance) 显示文摘 | Hauck S Benz M Brune A | 2006 | FEMS Microbiology Ecology2006，37，2： | 1 |
| 12 | Size ratio correlates with intracranial aneurysm rupture status: a prospective study 显示文摘 | Rahman M Smietana J Hauck E | 2010 | Stroke2010，41，5： | 1 |
| 13 | All transretinoic acid selectively down-regulates matrix metalloproteinase9 (MMP -9) and up -regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells显示文摘 | Frankenberger M Hauck RW Frankenberger B | 2001 | Mol Med2001，7，4： | 1 |
| 14 | Ductus ejaculatorius peptide 99B,a novel Drosophila melanogaster SP pheromone显示文摘 | Saudan P Hauck K Soller M | 2002 | European Journal of Biochemistry2002，269，： | 1 |
| 15 | Does an interspinous device (Coflex)improve the outcome of decompressive surgery in lumbar spinal stenosis One-year follow up of a prospective care control studv of 60 patients显示文摘 | Richter A Schütz C Hauck M | | 0，，： | 1 |
| 16 | All transretinoic acid selectinely down - regulates matrix metalloproteinase - 1 ( MMP - 9 )and up - regulates tissue inhibitor of metalloproteinase - 1 (TIMP - 1 ) in human bronchoalveolar lavage cells显示文摘 | Frankenberger M Hauck RW FrankenbergerB | 2001 | Mol Med2001，7，4： | 1 |
| 17 | Ultrastrnctural changes in soredia of the epiphytic lichen Hypogymnia physodes cultivated with manganese显示文摘 | Paul A Hauck M Langenfeld-Heyser R | 2004 | Environmental and Experimental Botany2004，52，： | 1 |
| 18 | 2,5 - Dimethyl-4- hydroxy -3 (2H)--Furanone as a Secondary Metabolite from D-Fructose- 1,6-Diphosphate Metabolism by Zygosaccharomyces rouxii 显示文摘 | Dahlen T Hauck T Wein M | 2001 | Journal of Bioscience and Bioengineering2001，91，4： | 1 |
| 19 | All trans-retindlc acid selectively down regulates matrix metalloproteinase-9(MMP-9)and up-regulated tissue inhibitor of metalloproteinase-1(TIMP-1)in human bronchoalveolar lavage cells显示文摘 | Frankenberger M Hauck RW Frankenberger B et a1 | 2001 | Mol Med2001，7，4： | 1 |
| 20 | 2-year follow-up after de- compressive surgery with and without implantation of an inter- spinous device for lumbar spinal stenosis :a prospective controlled study显示文摘 | Richter A Halm HF Hauck M | 2012 | J Spinal Disord Tech2012，，： | 1 |
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