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| 1 | 中国妇女宫颈癌组织中人乳头瘤病毒感染及其地理分布的调查显示文摘应用核酸印迹技术(Southern blot),对我国十四省市自治区的1455例来源宫颈癌、官颈不典型增生、宫颈湿疣和正常宫颈组织,进行人乳头瘤病毒(HPV)感染的型别检测,并分析了其型别地理分布特点。结果发现,815例宫颈癌组织 HPV 总检出率53.5%,其中 HPV16和58型检出率最高,分别是31.9%和7.6%,HPV6/11和18型的检出率为2.3%和1.0%。而在195例宫颈上皮不典型增生中,HPV 总检出率为25.1%,16/58型和6/11型的检出率分别为4.6%、15.9%。206例宫颈湿疣中,HPV 检出率40.8%,6/11型最高,达33.5%。239例正常宫颈组织中,仅检出1例 HPV16型,5例6/11型。提示:我国宫颈癌 HPV 感染以16、58型为主,18型少见。还发现,北方地区的宫颈癌组织中,HPV 感染以16型为主;南方省份长江中下游地区,HPV58 型检出率明显增高,几乎和 HPV16型持平;沿海地区不明的相关型呈上升趋势。提示我国宫颈癌 HPV 感染的型别,可能存在'移行'的地理分布特点。 | 李洁 刘宝印 zur Hausen H 王宏 杨学志 李力 刘文 刘洪隐 陆克昭 刘旭 牛春燕 裴润芳 苏钟浦 王言贵 董继华 张桂宁 刘春杰 许吉林 林毓纯 | 1996 | 中华实验和临床病毒学杂志1996，10，1： | 67 |
| 2 | Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 in patients with fatty liver diseases显示文摘AIM:To test the occurrence of the Pro12Ala mutation of the peroxisome proliferator-activated receptor-γ (PPARγ)2-gene in patients with non-alcoholic fatty liver disease (NAFLD) or alcoholic fatty liver disease (AFLD).METHODS:DNA from a total of 622 specimens including 259 blood samples of healthy blood donors and 363 histologically categorized liver biopsies of patients with NAFLD (n=263) and AFLD (n=100) were analyzed by Real-time polymerase chain reaction using allele-specific probes.RESULTS:In the NAFLD and the AFLD collective,3% of the patients showed homozygous occurrence of the Ala12 PPARγ2-allele,differing from only 1.5% cases in the healthy population.In NAFLD patients,a high incidence of the Ala12 mutant was not associated with the progression of fatty liver disease.However,we observed a significantly higher risk (odds ratio=2.50,CI:1.05-5.90,P=0.028) in AFLD patients carrying the mutated Ala12 allele to develop inflammatory alterations.The linkage of the malfunctioning Ala12-positive PPARγ2 isoform to an increased risk in patients with AFLD to develop severe steatohepatitis and fibrosis indicates a more prominent anti-inflammatory impact of PPARγ2 in progression of AFLD than of NAFLD.CONCLUSION:In AFLD patients,the Pro12Ala single nuclear polymorphism should be studied more extensively in order to serve as a novel candidate in biomarker screening for improved prognosis. | Johannes W Rey Andrea Noetel Aline Hardt Ali Canbay Hakan Alakus Axel zur Hausen Hans Peter Dienes Uta Drebber Margarete Odenthal | 2010 | World Journal of Gastroenterology2010，16，46： | 11 |
| 3 | The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer显示文摘 | Hartwig Riediger Tobias Keck Ulrich Wellner Axel Hausen Ulrich Adam Ulrich T. Hopt Frank Makowiec | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 5 |
| 4 | Papillomaviruses in the causation of human cancers — a brief historical account显示文摘 | Harald zur Hausen | 2008 | Virology2008，，2： | 4 |
| 5 | Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases显示文摘AIM: To investigate the expression of nucleoporin 88 (Nup88) in hepatitis B virus (HBV) and C virus (HCV)-related liver diseases. METHODS: We generated a new monoclonal Nup88 antibody to investigate the Nup88 protein expression by immunohistochemistry (IHC) in 294 paraffin-embedded liver specimens comprising all stages of hepatocellular carcinogenesis. In addition, in cell culture experiments HBV-positive (HepG2.2.15 and HB611) and HBV-negative (HepG2) hepatoma cell lines were tested for the Nup88 expression by Western-immunoblotting to test data obtained by IHC.RESULTS: Specific Nup88 expression was found in chronic HCV hepatitis and unspecific chronic hepatitis, whereas no or very weak Nup88 expression was detected in normal liver. The Nup88 expression was markedly reduced or missing in mild chronic HBV infection and inversely correlated with HBcAg expression. Irrespective of the HBV- or HCV-status, increasing Nup88 expression was observed in cirrhosis and dysplastic nodules, and Nup88 was highly expressed in hepatocellular carcinomas. The intensity of Nup88 expression significantly increased during carcinogenesis (P < 0.0001) and correlated with dedifferentiation (P < 0.0001). Interestingly, Nup88 protein expression was significantly downregulated in HBV-positive HepG2.2.15 (P < 0.002) and HB611 (P < 0.001) cell lines as compared to HBV-negative HepG2 cells. CONCLUSION: Based on our immunohistochemical data, HBV and HCV are unlikely to influence the expression of Nup88 in cirrhotic and neoplastic liver tissue, but point to an interaction of HBV with the nuclear pore in chronic hepatitis. The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. | Martina Knoess Anna Kordelia Kurz Olga Goreva Nuran Bektas Kai Breuhahn Magarethe Odenthal Peter Schirmacher Hans Peter Dienes C Thomas Bock Hanswalter Zentgraf Axel zur Hausen | 2006 | World Journal of Gastroenterology2006，12，36： | 4 |
| 6 | The Lymph Node Ratio is the Strongest Prognostic Factor after Resection of Pancreatic Cancer显示文摘 | Hartwig Riediger Tobias Keck Ulrich Wellner Axel Hausen Ulrich Adam Ulrich T. Hopt Frank Makowiec | 2009 | Journal of Gastrointestinal Surgery2009，，7： | 2 |
| 7 | Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast显示文摘 | De Villiers EM Sandstrom RE zur Hausen H | 2005 | Breast Cancer Res2005，7，1： | 1 |
| 8 | Cervical carcinoma and human papillomavirus : on the road to preventing amaj or human cancer 显示文摘 | zur Hausen H | 2001 | J Nat Cancer Inst2001，93，4： | 1 |
| 9 | Photopateh testing : The 5 Year experience of the German, Austrian, and Swiss photopatch test group 显示文摘 | HOLZLE E NEUMANN N HAUSEN B | 1991 | J Am Acad Dermatol1991，25，1： | 1 |
| 10 | Changes in toothbrushingfrequency in relation to changes in oral health-related knowledge andattitudes among children:A longitudinal study显示文摘 | TOLVANEN M LAHTI S HAUSEN H | 2010 | Eur J Oral Sci2010，118，3： | 1 |
| 11 | Papillomavirus infections--a major cause of human cancers显示文摘 | zur Hausen H | 1996 | Biochim Biophys Acta1996，1288，2： | 1 |
| 12 | Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis显示文摘 | Zur Hausen H | 2000 | J Natl Cancer Inst2000，92，9： | 1 |
| 13 | In vivo measurement of lung preservation solution efficacy: comparison of LPD, UW,EC and low K+EC following short and extended ischemia 显示文摘 | HAUSEN B BEUKE M SCHROEDER F | 1997 | Eur J Cardiothorac Surg1997，12，5： | 1 |
| 14 | Prevention of acute allograft rejection in nohuman primate lung transplant receipients 显示文摘 | Hausen B Gummert J Berry GJ | 2000 | Transplantation2000，69，： | 1 |
| 15 | Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival:Warburg effect reinterpreted显示文摘 | Langbein S Zerilli M Zur Hausen A | 2006 | Br J Cancer2006，94，4： | 1 |
| 16 | A synthetic E7 gene of human papillomavirus type 16 that yields enhanced expression of the protein in mammalian cells and is useful for DNA immunization studies显示文摘 | Cid-Arregui A Juarez V zur Hausen H | 2003 | J Virol2003，77，88： | 1 |
| 17 | Papillomaviruses and cancer: from basic studies to clinical application显示文摘 | Zur Hausen H | 2002 | NatRev Cancer2002，2，5： | 1 |
| 18 | Cervical carcinoma and human papillomavirus on the road to preventing a major human cancer 显示文摘 | zur Hausen H | 2001 | J Natl Cancer Inst2001，93，4： | 1 |
| 19 | Papilloma viruses and cancer:from basic studies to clinical application显示文摘 | zur Hausen H | 2002 | Nat Rev Cancer2002，2，5： | 1 |
| 20 | Papillomaviruses and cancer: from basic studies to clinical application 显示文摘 | zur Hausen H | 2002 | Nat Rev Cancer2002，2，34： | 1 |
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