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| 1 | Sodium alendronate loaded poly(L-lactideco-glycolide)microparticles immobilized on ceramic scaffolds for local treatment of bone defects显示文摘Bone tissue regeneration in critical-size defects is possible after implantation of a 3D scaffold and can be additionally enhanced once the scaffold is enriched with drugs or other factors supporting bone remodelling and healing.Sodium alendronate(Aln),a widely used anti-osteoporosis drug,exhibits strong inhibitory effect on bone resorption performed by osteoclasts.Thus,we propose a new approach for the treatment of bone defects in craniofacial region combining biocompatible titanium dioxide scaffolds and poly(L-lactide-co-glycolide)microparticles(MPs)loaded with Aln.The MPs were effectively attached to the surface of the scaffolds’pore walls by human recombinant collagen.Drug release from the scaffolds was characterized by initial burst(2466% of the drug released within first 24 h)followed by a sustained release phase(on average 5 mg of Aln released per day from Day 3 to Day 18).In vitro tests evidenced that Aln at concentrations of 5 and 2.5 mg/ml was not cytotoxic for MG-63 osteoblast-like cells(viability between 8166% and 9863% of control),but it prevented RANKL-induced formation of osteoclast-like cells from macrophages derived from peripheral blood mononuclear cells,as shown by reduced fusion capability and decreased tartrateresistant acid phosphatase 5b activity(5665% reduction in comparison to control after 8 days of culture).Results show that it is feasible to design the scaffolds providing required doses of Aln inhibiting osteoclastogenesis,reducing osteoclast activity,but not affecting osteoblast functions,which may be beneficial in the treatment of critical-size bone tissue defects. | Lucja Rumian Cornelia Wolf-Brandstetter Sina Roβler Katarzyna Reczynska Hanna Tiainen Havard J.Haugen Dieter Scharnweber Elzbieta Pamula | 2020 | Regenerative Biomaterials2020，7，3： | 5 |
| 2 | Prospective multicentre randomised controlled trial of early enteral nutrition for patients undergoing major upper gastrointestinal surgical resection显示文摘 | Rachael Barlow Patricia Price Thomas D. Reid Sarah Hunt Geoffrey W.B. Clark Timothy J. Havard Malcolm C.A. Puntis Wyn G. Lewis | 2011 | Clinical Nutrition2011，，5： | 2 |
| 3 | Antimicrobial properties of lactoferrin 显示文摘 | Havard Jenssen Robert E W Hancock | 2009 | Biochimie2009，，91： | 1 |
| 4 | Best ethical practices for clinicians and laboratories in the provision of non-invasive prenatal testing显示文摘 | Allyse MA Sayres LC Havard M | 2013 | Prenat Diagn2013，33，7： | 1 |
| 5 | Yield,vitamin and mineral content of four vegetables grown with either composed manure or conventional fertilizer显示文摘 | Warman P R Havard K A | 1996 | J Veg Crop Prod1996，2，1： | 1 |
| 6 | Best ethical practices for clinicians and laboratories in the provision of Non-Invasive Prenatal Testing显示文摘 | Allyse MA Sayres LC Havard M | 2013 | Prenat Diagn2013，33，7： | 1 |
| 7 | Galloping database on single and bundle conductors prediction of maximum amplitudes 显示文摘 | Lilien J L Havard D G | 2000 | Power Delivery IEEE Transactions on2000，15，2： | 1 |
| 8 | Yield, vitamin and mineral contents of organically and conventionally grown potatoes and sweet corn显示文摘 | WARMAN P R HAVARD K A | 1998 | Agriculture Ecosystems & Environment1998，68，30： | 1 |
| 9 | Depression among entrants to treatment for heroin dependence in the Australian Treatment Outcome Study ( ATOS ) : prevalence, correlates and treatment seeking显示文摘 | Teessona M Havard A Fairbairn S | 2005 | Drug Alcohol Depen2005，78，3： | 1 |
| 10 | Depression among heroin users: 12-Month outcomes from the Australian Treatment Outcome Study (ATOS) 显示文摘 | Havard A Teesson M Darke S | 2006 | J Subst Abuse Treat2006，30，4： | 1 |
| 11 | Grain harvesting,threshing and cleaning显示文摘 | Cruz J F Havard M | 1994 | Agricultural Services Div1994，，： | 1 |
| 12 | Peptide antimicrobial agents 显示文摘 | Havard Jenssen Pamela Hamill Robert EW | 2006 | Clinical Microbiology Reviews2006，19，3： | 1 |
| 13 | Effectiveness of hot water,infrared and open flame thermal units for controlling weeds显示文摘 | Astatkie T Rifai1 M N Havard P | 2007 | Biological Agriculture & Horticulture2007，25，1： | 1 |
| 14 | High levels of p105(NFKB1) and p100 (NFKB2) proteins in HPV16-transformed keratinocytes:role of E6 and E7 oncoproteins显示文摘 | Rahmouni S Boniver J | 2005 | Virology2005，331，2： | 1 |
| 15 | The alkaline aluminium/hydrogen peroxide power source in the Hugin II unmanned underwater vehicle 显示文摘 | Qistein Hasvoht Kjell Havard Johansen Ole Mollestad | 1999 | Journal of Power Sources1999，80，： | 1 |
| 16 | An assessment of ehloramphenieol and thiamphenieol in the induction of aplastic anaemia in the BALB/c mouse显示文摘 | Turton J A Havard A C Robinson S Holt D E Andrew S C M Fagg R Willams T C | 2000 | Food and Chemi- cal Toxicology2000，38，： | 1 |
| 17 | High levels of p105 (NFKB1) and pl00 (NFKB2) proteins in HPV16- transformed keratinocytes: role of E6 and E7 oncopro- teins显示文摘 | Havard L Rahmouni S Boniver J | 2005 | Virology2005，331，2： | 1 |
| 18 | Internal bone transport using a cannulated screw as a mounting device in the treatment of a post-infective ulnar defect显示文摘 | Tsitskaris K Havard H Bijlsma P | 2016 | Strategies Trauma Limb Reconstr2016，11，1： | 1 |
| 19 | Economic Growth and Land-Use Changes: the Declining Amount of Wilderness Land in Norway显示文摘 | ANDERS S HAVARD S | 2001 | Ecological Economics2001，37，2： | 1 |
| 20 | Scour below pipelines and around vertical piles in random waves 显示文摘 | Dag Myrhaug Havard Rue | 2003 | Coastal Engineering2003，48，： | 1 |
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