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| 1 | Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?显示文摘AIM To study the relationship between overhydration(OH) in peritoneal dialysis(PD) patients and cardiac mortality.METHODS OH, as measured by body composition monitor(BCM), is associated with increased mortality in dialysis patients. BCM has been used to guide treatment on the assumption that correcting OH will improve cardiac morbidity and mortality although data demonstrating causality that is reversible is limited. We wished to determine if OH in PD patients predicted cardiac mortality, and if there was a correlation between OH and cardiac troponin-T(cT n T) levels. Finally, we wished to determine if improving OH values would lead to a decrement in cT n T. All prevalent PD patients over the study period of 57 mo who had contemporaneous BCM and cT nT measurements were followed irrespective of transplantation or PD technique failure. We also studied a cohort of patients with who had severe OH(> +2L).The Fresenius Body Composition Monitor was used to obtain hydration parameters. cT nT levels were done as part of routine clinical care. Data was analysed using SPSS version 20.0.RESULTS There were 48 deaths in the 336 patients. The patients that died from cardiac or non-cardiac causes were similar with respect to their age, incidence of diabetes mellitus, gender, ethnicity and cause of renal failure. However, the patients with cardiac causes of death had significantly shorter dialysis vintage(10.3 mo vs 37.0 mo, P < 0.0001) and were significantly more overhydrated by BCM measurement(2.95 L vs 1.35 L, P < 0.05). The mean(standard error of the means) hydration status of the 336 patients was +1.15(0.12) L and the median [interquartile range(IQR)] cT nT level was 43.5(20-90) ng/L. The cT nT results were not normally distributed and were therefore transformed logarithmically. There was a statistically significant correlation between Log(cT nT) with the OH value(Spearman r value 0.425, P < 0.0001). We identified a sub-group of patients that were severely overhydrated; median(IQR) hydration at baseline was +2.7(2.3 to 3.7) L. They were followed up for a minimum of 6 mo. Reduction in OH values in these patients over 6 mo correlated with lowering of cT nT levels(Spearman r value 0.29, P < 0.02). CONCLUSION Patients that were overhydrated had higher cT nT, and had deaths that were more likely to be cardiac related. Reduction in OH correlated with lowering of cT nT. | Elizabeth Oei Klara Paudel Annemarie Visser Hazel Finney Stanley L Fan | 2016 | World Journal of Nephrology2016，5，5： | 4 |
| 2 | Immunohis tochemincal detection of inducible nitric oxide synthase, nitroty rosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia显示文摘 | STE-MARIE L HAZELL AS BEMEUR C | 2001 | Brain Res2001，918，： | 1 |
| 3 | Dual transplantation of hu- man neural stem cells into cervical and lumbar cord ameliorates motor neuron disease in SODI transgenic rats 显示文摘 | Xu L Shen P Hazel T | 2011 | Neurosci Lett2011，494，3： | 1 |
| 4 | Market Interven-tion Policies When Production Is Risky显示文摘 | HAZELL P B R SCANDIZZO P L | 1975 | American Journal of Agricultural Economics1975，57，4： | 1 |
| 5 | Molecular mechanisms of temperature compensafion in poikilothermos 显示文摘 | Hazel J R Prosser C L | 1974 | Physiol Rev1974，54，： | 1 |
| 6 | Molecular mechanisms of tem- perature compensation in poikilotherms 显示文摘 | HAZEL J R PROSSER C L | 1974 | Physiological Reviews1974，54，： | 1 |
| 7 | The steady propagation of a semi-infinite bubble into a tube of elliptical or rectangular cross-section 显示文摘 | Hazel A L Heil M | 2002 | Journal of Fluid Mechanics2002，470，： | 1 |
| 8 | Determination of trazodone and its metabolite,1-mChlorophenyl-piperazine,in human plasma and red blood cell samples by HPLC显示文摘 | VATASSERY G T HOLDEN L A HAZEL D K | 1997 | Clinical Biochemistry1997，30，2： | 1 |
| 9 | The usefulness of Vistech and FACT contrast sensitivity charts for cataract and refractive surgery outcomes research 显示文摘 | Pesudovs K Hazel C A Doran R M L | 2004 | Scientific Re- port2004，88，1： | 1 |
| 10 | The efficiency of three methods of selection 显示文摘 | Hazel L N LushJ L | 1942 | Journal of Heredity1942，33，： | 1 |
| 11 | Presence of hypochlorite- modified proteins in human atherosclerotic lesions 显示文摘 | Hazell LG Arnold L Flowers D | 1999 | J Clin Invest1999，103，15： | 1 |
| 12 | Spring constants of composite ceramic/gold cantilevers for scanning probe microscopy 显示文摘 | Hazel J L Tsukruk V V | 1999 | Thin Solid Films1999，339，2： | 1 |
| 13 | Immuno-histochemical detection of inducible nitric oxide syn-thase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia显示文摘 | Ste-Marie L Hazell AS Bemeur C | 2001 | BrainRes2001，918，12： | 1 |
| 14 | 8-Methylaminoquinolinium Salts of Tetrachtorodimethylstannate(IV) and Tetrachlorodiphenylstannate(IV)显示文摘 | Hazell A Khoo L E Ouyang J | 1998 | Acta Cryst1998，54，： | 1 |
| 15 | Immunohistochemical detection of inducible nitric oxide synthase,nitrotyrosine and maganese superoxide dismutase following hyperglycemic focal cerebral显示文摘 | Hazell AS Bemeur C | 2001 | Brain RES2001，918，12： | 1 |
| 16 | Under-reporting of adverse drug reactions : a systematic review 显示文摘 | Hazell L Shakir SA | 2006 | Drug safety2006，29，5： | 1 |
| 17 | Immunohistochemical detection of inducible nitric oxide synthase,nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia显示文摘 | Hazell AS Bemeur C | 2001 | Brain Res2001，918，12： | 1 |
| 18 | Mitochondrial H^sub 2^O^sub 2^ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans显示文摘 | Anderson Ethan J Lustig Mary E Boyle Kristen E Woodlief Tracey L Kane Daniel A Lin Chien-Te Rice Jesse W Kang Li Rabinovitch Peter S Szeto Hazel H Houmard Joseph A Cortright Ronald N Wasserman David H Neufer P Darrell | 2009 | Journal of Clinical Investigation2009，，3： | 1 |
| 19 | The Steady Propagation of a Semiinfinite Bubble into a Tube of Elliptical or Rec- tangular Cross-Section显示文摘 | HAZEL A L HEIL M | 2002 | Journal of Fluid Mechan- ics2002，470，1： | 1 |
| 20 | Neurophysiological model of tinnitus: dependence of the minimal masking level on treatment outcome显示文摘 | JASTREBOFF P J HAZELL J W GRAHAM R L | 1994 | Hear Res1994，80，： | 1 |
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