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| 1 | 麝香保心丸对内皮素-1诱导原代培养的人脐动脉血管平滑肌细胞增殖的影响显示文摘目的:观察麝香保心丸(SXBXW)对内皮素-1(ET-1)诱导原代培养的人脐动脉血管平滑肌细胞(VSMCs)增殖作用的影响。方法:建立ET-1刺激原代培养人脐动脉VSMCs增殖的细胞模型,设对照组、ET-1组、ET-1+SXBXW0.25g/L组、ET-1+SXBXW0.5g/L组、ET-1+SXBXW1.0g/L组和ET-1+SXBXW2.0g/L组,采用MTT法测定ET-1和SXBXW对细胞增殖的影响;用台盼蓝拒染和乳酸脱氢酶检测方法观察不同浓度的SXBXW对VSMCs的毒性作用;用流式细胞术观察ET-1和SXBXW对VSMCs增殖周期的影响。结果:与对照组相比,ET-1可显著促进VSMCs的增殖,一定剂量的SXBXW能够有效地抑制ET-1诱导的VSMCs细胞增殖,呈剂量依赖性;SXBXW抑制细胞增殖,但对活细胞数目和乳酸脱氢酶释放量均没有影响,提示对VSMCs无毒性作用。ET-1能够刺激VSMCs从G1期进入S期,从而促进细胞增殖,而SXBXW能抑制这一作用。结论:SXBXW能够有效抑制ET-1诱导的VSMCs增殖作用,其作用机制可能与其抑制细胞周期从G1期进入S期有关。 | 车贤达 张庆刚 钱琳艳 张晓慧 高瑞兰 Beng HC Simon XL Xinmai J | 2010 | 中国病理生理杂志2010，26，2： | 8 |
| 2 | 非诺贝特治疗与2型糖尿病患者长期心血管病风险的关系显示文摘2型糖尿病患者心血管病风险高,部分原因在于高三酰甘油和低高密度脂蛋白胆固醇血症。而在他汀类药物治疗基础上,加强降低三酰甘油治疗,能否降低这种风险尚不清楚。该研究的目的是在使用他汀类药物治疗的2型糖尿病患者中,确定非诺贝特能否降低心血管病风险。 | 刘莉 叶鹏 Elam MB Ginsberg HN Lovato LC Corson M Largay J Leiter LA Lopez C O'Connor PJ Sweeney ME Weiss D Friedewald WT Buse JB Gerstein HC Probstfield J Grimm R Ismail-Beigi F Goff DC Jr Fleg JL Rosenberg Y Byington RP ACCORDION study investigators | 2017 | 中华高血压杂志2017，25，6： | 7 |
| 3 | Cytomegalovirus in inflammatory bowel disease: Asystematic review显示文摘AIM: To identify definitions of cytomegalovirus(CMV) infection and intestinal disease, in inflammatory bowel disease(IBD), to determine the prevalence associated with these definitions.METHODS: We conducted a systematic review and interrogated Pub Med, EMBASE and Cochrane for literature on prevalence and diagnostics of CMV infection and intestinal disease in IBD patients. As medical headings we used 'cytomegalovirus' OR 'CMV' OR 'cytomegalo virus' AND 'inflammatory bowel disease' OR 'IBD' OR 'ulcerative colitis' OR 'colitis ulcerosa' OR 'Crohn's disease'. Both Me SH-terms and free searches were performed. We included all types of English-language(clinical) trials concerning diagnostics and prevalence of CMV in IBD.RESULTS: The search strategy identified 924 citations, and 52 articles were eligible for inclusion. We identified 21 different definitions for CMV infection, 8 definitions for CMV intestinal disease and 3 definitions for CMV reactivation. Prevalence numbers depend on used definition, studied population and region. The highest prevalence for CMV infection was found when using positive serum PCR as a definition, whereas for CMV intestinal disease this applies to the use of tissue PCR > 10 copies/mg tissue. Most patients with CMV infection and intestinal disease had steroid refractory disease and came from East Asia.CONCLUSION: We detected multiple different definitions used for CMV infection and intestinal disease in IBD patients, which has an effect on prevalence numbers and eventually on outcome in different trials. | Tessa EH Römkens Geert J Bulte Loes HC Nissen Joost PH Drenth | 2016 | World Journal of Gastroenterology2016，22，3： | 6 |
| 4 | Analysis of the PINK1 gene in a cohort of patients with sporadic earlyonset parkinsonism in Taiwan显示文摘 | Fung HC Chen CM Hardy J Singleton AB Lee-Chen GJ Wu YR | 2006 | 中国生物学文摘2006，20，8： | 6 |
| 5 | MATCH试验:氯吡格雷对近期短暂性脑缺血发作或缺血性卒中高危患者动脉粥样硬化的治疗研究显示文摘MATCH(Management of Atherothrombosis with Clopidogel in High—Risk Patients with Recent Transient Ischemic or Ischemic Stroke)试验是针对近期发生短暂性脑缺血发作(TIA)或缺血性卒中患者进行的大规模临床研究,为一项国际性多中心随机双盲对照临床试验。初级目标是评价氯吡格雷与阿司匹林联合应用能否获得更多临床效益以及进一步减少缺血事件(心肌梗死、缺血性卒中、血管性死亡事件及因急性缺血事件再住院)的发生。共有28个国家的507个医疗中心参与了该项研究,共纳入7599例受试者,随访18个月。 | Diener HC Bogousslavsky J Brass LM 王蔚 | 2009 | 中国现代神经疾病杂志2009，9，1： | 3 |
| 6 | Improved cryopreservation of human embryonic stem cells with trehalose显示文摘 | Wu CF Tsung HC Zhang W J Wang Y Lu JH Tang ZY Kuang YP Jin W Cui L Liu W Cao YL | 2006 | 中国生物学文摘2006，20，7： | 2 |
| 7 | Evaluating film-forming corrosion inhibitors for carbon steel in gas-well environments显示文摘 | Oung J C Shih HC | 1997 | Corrosion Prevention and Control1997，44，3： | 2 |
| 8 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 9 | QUADRILATERAL FINITE ELEMENTS FOR PLANAR LINEAR ELASTICITY PROBLEM WITH LARGE LAME CONSTANT显示文摘In this paper, we discuss the quadrilateral finite element approximation to the two-dimensional linear elasticity problem associated with a homogeneous isotropic elastic material. The optimal convergence of the finite element method is proved for both the L2-norm and energy-norm, and in particular, the convergence is uniform with respect to the Lain6 constant A. Also the performance of the scheme does not deteriorate as the material becomes nearly incompressible. Numerical experiments are given which are consistent with our theory. | Cheng, XL Huang, HC Zou, J | 1998 | Journal of Computational Mathematics1998，16，4： | 2 |
| 10 | Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus显示文摘 | Li WL Zheng HC Bukuru J | 2004 | J Ethnopharmacol2004，92，1： | 1 |
| 11 | Radioprotective effeats of diltiazem on cytogenetic damage and survival in gamma ray exposed mice显示文摘 | Goel HC Ganguly SK Prasad J | 1996 | Indian J Expertal Bio1996，34，12： | 1 |
| 12 | Dose-response relationship in local radiotherapy for hepatocellular carcinoma显示文摘 | Park HC Seong J Han KH | 1996 | Int J Radiat Oncol Biol Phys1996，40，1： | 1 |
| 13 | Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: The HOPE randomized trial 显示文摘 | Mann JF Gerstein HC Pogue J | 2001 | Ann Intern Med2001，134，8： | 1 |
| 14 | Population based study of risk factors for under diagnosis of asthma in adolescence:Oddness school child study显示文摘 | Siersted HC Boldsen J Hansen HS | 1998 | BMJ1998，316，7312： | 1 |
| 15 | Medullary serotogernic network deficiency in the sudden infant death syndrome: review of a 15-year study of a single database显示文摘 | Kinney HC Filiano J J White WF | 2001 | J Neuropathol Exp Neurol2001，60，3： | 1 |
| 16 | Expression of steroid receptor coactivators and corepressors in human endometrial hyper- plasia and carcinoma with relevance to steroid receptors and Ki - 67 expression 显示文摘 | Uchikawa J Shiozawa T Shih HC | 2003 | Cancer2003，98，10： | 1 |
| 17 | Local radiotherapy for unre- sectable hepatocellular carcinoma patients who failed with tran- scatheter arterial chemoembolization显示文摘 | Seong J Park HC Han KH | 2000 | Int J Radiat Oncol Biol Phys2000，47，5： | 1 |
| 18 | Five-year fol- low-up of the medical research council CLASICC trial of laparoscopically assisted versus open surgery for colorectal cancer显示文摘 | Jayne DG Thorpe HC Copeland J | 2010 | Br J Surg2010，97，： | 1 |
| 19 | Clostridium difficile infection at a medical center in southern Taiwan: incidence, clinical features and prognosis显示文摘 | Chung CH Wu C J Lee HC | 2010 | J Microbiol Immunol Infect2010，43，2： | 1 |
| 20 | It's all in the family:Family counseling for depressed children显示文摘 | Crethar HC Snow K Carlson J | | 0，，： | 1 |
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