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| 1 | Accuracy of myocardial viability imaging by cardiac MRI and PET depending on left ventricular function显示文摘AIM To compare myocardial viability assessment accuracy of cardiac magnetic resonance imaging(CMR)compared to[^(18)F]-fluorodeoxyglucose(FDG)-positron emission tomography(PET)depending on left ventricular(LV)function.METHODS One-hundred-five patients with known obstructive coronary artery disease(CAD)and anticipated coronary revascularization were included in the study and examined by CMR on a 1.5T scanner.The CMR protocol consisted of cine-sequences for function analysis and late gadolinium enhancement(LGE)imaging for viability assessment in 8 mm long and contiguous short axis slices.All patients underwent PET using[^(18)F]-FDG.Myocardial scars were rated in both CMR and PET on a segmental basis by a 4-point-scale:Score 1=no LGE,normal FDG-uptake;score 2=LGE enhancement<50% of wall thickness,reduced FDG-uptake(≥50% of maximum);score 3=LGE≥50% ,reduced FDG-uptake(<50% of maximum);score 4=transmural LGE,no FDG-uptake.Segments with score 1 and 2 were categorized'viable',scores 3 and 4 were categorized as'non-viable'.Patients were divided into three groups based on LV function as determined by CMR:Ejection fraction(EF),<30% :n=45;EF:30% -50% :n=44;EF>50% :n=16).On a segmental basis,the accuracy of CMR in detecting myocardial scar was compared to PET in the total collective and in the three different patient groups.RESULTS CMR and PET data of all 105 patients were sufficient for evaluation and 5508 segments were compared in total.In all patients,CMR detected significantly more scars(score 2-4)than PET:45% vs 40% of all segments(P<0.0001).In the different LV function groups,CMR found more scar segments than PET in subjects with EF<30% (55% vs 46% ;P<0.0001)and EF 30% -50% (44% vs 40% ;P<0.005).However,CMR revealed less scars than PET in patients with EF>50% (15% vs 23% ;P<0.0001).In terms of functional improvement estimation,i.e.,expected improvement after revascularization,CMR identified'viable'segments(score 1 and 2)in 72% of segments across all groups,PET in 80% (P<0.0001).Also in all LV function subgroups,CMR judged less segments viable than PET:EF<30% ,66% vs 75% ;EF=30% -50% ,72% vs 80% ;EF>50% ,91% vs 94% .CONCLUSION CMR and PET reveal different diagnostic accuracy in myocardial viability assessment depending on LV function state.CMR,in general,is less optimistic in functional recovery prediction. | Peter Hunold Heinz Jakob Raimund Erbel Jorg Barkhausen Christina Heilmaier | 2018 | World Journal of Cardiology2018，10，9： | 3 |
| 2 | Ductility and impact resistance of powder-metallurgical molybdenum-rhenium alloys 显示文摘 | Leichtfried G Schneibel J H Heilmaier M | 2006 | Metallurgical and materials transactions A2006，37，10： | 1 |
| 3 | Microstructure and mechanical properties of Cu-Ag mi-crocomposites for conductor wires in pulsed magnets' 显示文摘 | GRUNBERGER W HEILMAIER M SCHULTZ L | 2002 | Z Metallkd2002，93，1： | 1 |
| 4 | Creep properties of anoxide dispersion strengthened nickel-base alloy显示文摘 | Estrin Y Heilmaier M Drew G | 1999 | Mater Sci Eng A1999，272，1： | 1 |
| 5 | Development of highstrength and high-conductivity conductor materials for pulsed high-field magnets at Dresden显示文摘 | Grunberger W Heilmaier M Schuhz L | 2001 | Physica B2001，，： | 1 |
| 6 | Mapping of hepatic vascular anatomy: dynamic contrast-enhanced parallel MR imaging compared with 64 detector row CT 显示文摘 | Heilmaier C Sutter R Lutz AM | 2007 | Radiology2007，245，3： | 1 |
| 7 | Supersaturated solid solution of niobium in copper by mechanical alloying显示文摘 | Botcharova E Heilmaier M Freudenberger J | 2003 | J Alloys Comp2003，351，12： | 1 |
| 8 | Assessment of the High Temperature Deformation Behavior of Molybdenum Silicide Alloys显示文摘 | J′ehanno P Heilmaier M Saage H | 2007 | Materials Science and Engineering A2007，463，： | 1 |
| 9 | Microstructure and mechanical properties of Cu-Ag microcomposites for conductor wires in pulsed high-field magnets显示文摘 | Grünberger W Heilmaier M Schultz L | 2002 | Z Metallkd2002，93，1： | 1 |
| 10 | Assess- ment of left ventricular function with single breath-hold highly ac- celerated cine MRI combined with guide-point modeling显示文摘 | Heilmaier C Nassenstein K Nielles-Vallespin S | 2010 | EurJ Radiol2010，74，3： | 1 |
| 11 | Development of high-strength and high-conductivity conductor materials for pulsed high-field magnets at Dresden显示文摘 | Grünberger W Heilmaier M Schultz L | 2001 | Physica B2001，，： | 1 |
| 12 | Cyclic stress-strain response of the ODS nickel-base, superalloy PM 1000 under variable amplitude loading at high temperatures显示文摘 | Heilmaier M Maier H J Jung A | 2000 | Materials Science and Engineering2000，281，1： | 1 |
| 13 | Ductilization of Mo-Si solid solutions manufactured by powder metallurgy显示文摘 | SAAGE H STURM D HEILMAIER M | 2009 | Acta Materialia2009，57，： | 1 |
| 14 | Supersaturated solid solution of niobium in copper by mechanical alloying显示文摘 | BOTCHAROVA E HEILMAIER M FREUDENBERGER J DREW G KUDASHOW D MARTIN U SCHULTZ L | 2003 | Journal of Alloys and Compounds2003，351，12： | 1 |
| 15 | Supersaturated solid solution of niobium in copper by mechanical alloying 显示文摘 | Botcharova E Heilmaier M Freudenberger J Drew G Kudashow D Martin U Schultz L | 2003 | Journal of Alloys and Compounds2003，，351： | 1 |
| 16 | Microstructure and mechanical properties of nanostructured A1-4Cu alloy produced by mechanical alloying and vacuum hot pressing 显示文摘 | SHANMUGASUNDARAM T HEILMAIER M MURTY B S SUBRAMANYA SARMA V | 2009 | Metallurgical and Materials Transactions A2009，40，12： | 1 |
| 17 | Newtonian flow of Zr55Cu30Al10Ni5 bulk metallic glassy alloys显示文摘 | Reger-Leonhard A Heilmaier M Eckert J | | 0，，05： | 1 |
| 18 | Formation of ODS Ll2(Al,Cr)3Ti by mechanical alloying显示文摘 | Heilmaier M Saage H Eckert J | 1997 | Materials Science and Engineering1997，，： | 1 |
| 19 | Mapping of hepatic vascular a- natomy: dynamic contrast-enhanced parallel MR imaging compared with 64 detector row CT显示文摘 | Heilmaier C Sutter R Lutz AM | 2007 | Radiology2007，45，： | 1 |
| 20 | Characterization of microstructures,mechanical properties,and oxidation behavior of coherent A2+L21Fe-Al-Ti显示文摘 | Krein R Palm M Heilmaier M | 2009 | Journal of Materials Research2009，24，11： | 1 |
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