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| 1 | Early therapeutic effect of platelet-rich fibrin combined with allogeneic bone marrow-derived stem cells on rats’ critical-sized mandibular defects显示文摘BACKGROUND Critically sized bone defects represent a significant challenge to orthopaedic surgeons worldwide.These defects generally result from severe trauma or resection of a whole large tumour.Autologous bone grafts are the current gold standard for the reconstruction of such defects.However,due to increased patient morbidity and the need for a second operative site,other lines of treatment should be introduced.To find alternative unconventional therapies to manage such defects,bone tissue engineering using a combination of suitable bioactive factors,cells,and biocompatible scaffolds offers a promising new approach for bone regeneration.AIM To evaluate the healing capacity of platelet-rich fibrin(PRF)membranes seeded with allogeneic mesenchymal bone marrow-derived stem cells(BMSCs)on critically sized mandibular defects in a rat model.METHODS Sixty-three Sprague Dawley rats were subjected to bilateral bone defects of critical size in the mandibles created by a 5-mm diameter trephine bur.Rats were allocated to three equal groups of 21 rats each.Group I bone defects were irrigated with normal saline and designed as negative controls.Defects of group II were grafted with PRF membranes and served as positive controls,while defects of group III were grafted with PRF membranes seeded with allogeneic BMSCs.Seven rats from each group were killed at 1,2 and 4 wk.The mandibles were dissected and prepared for routine haematoxylin and eosin(HE)staining,Masson's trichrome staining and CD68 immunohistochemical staining.RESULTS Four weeks postoperatively,the percentage area of newly formed bone was significantly higher in group III(0.88±0.02)than in groups I(0.02±0.00)and II(0.60±0.02).The amount of granulation tissue formation was lower in group III(0.12±0.02)than in groups I(0.20±0.02)and II(0.40±0.02).The number of inflammatory cells was lower in group III(0.29±0.03)than in groups I(4.82±0.08)and II(3.09±0.07).CONCLUSION Bone regenerative quality of critically sized mandibular bone defects in rats was better promoted by PRF membranes seeded with BMSCs than with PRF membranes alone. | Muhammad A Awadeen Fouad A Al-Belasy Laila E Ameen Mohamad E Helal Mohammed E Grawish | 2020 | World Journal of Stem Cells2020，12，1： | 4 |
| 2 | Association betweenNterminal propeptide B-type natriuretic peptide and markers ofhypervolemia显示文摘 | Gangji A S Helal B A Churchill D N | 2008 | Perit Dial Int2008，28，3： | 1 |
| 3 | Bit-sequences : an adaptive cache invalidation method in mobile client/ server environments 显示文摘 | Jing J Elmagarmid A Helal A | 1997 | Mobile Networks and Applica- tions1997，2，2： | 1 |
| 4 | Aminopyrimidine deriva- tives as inhibitors for corrosion of 1018 carbon steel in nitricacid solution 显示文摘 | Abdallah M Helal E A Fouda A S | 2006 | Corrosion Science2006，48，7： | 1 |
| 5 | Client-server computing in mobile environments 显示文摘 | Jing J Helal A Elmangarmid A | 1999 | ACM Computing Surveys1999，31，2： | 1 |
| 6 | Effect of curing time on the physicomechanical characteristics of the hardened cement pastes containing limestone 显示文摘 | Helal M A | 2002 | Cement and Concrete Research2002，32，3： | 1 |
| 7 | Konark: A System and Protocols for Device Independent, Peer-to-Peer Discovery and Delivery of Mobile Services 显示文摘 | Lee C Helal A Desai N | 2003 | IEEE Transactions on Systems Man and Cybernetics2003，33，6： | 1 |
| 8 | Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine显示文摘 | ABD-ALLAH A R HELAL G K AL-YAHYA A A | 2009 | Oxidative Medicine and Cellular Longevity2009，2，2： | 1 |
| 9 | Characterization of different humic materials by various analytical techniques显示文摘 | HELAL A A MURAD GA HELAL A A | | Arabian Journal of Chemistry0，4，： | 1 |
| 10 | Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease显示文摘 | HELAL C J SANNER M A COOPER C B | 2004 | Bioorg Med Chem Lett2004，14，22： | 1 |
| 11 | Location-based services: Back to the future 显示文摘 | BELLAVISTA P KUPPER A HELAL S | 2008 | IEEE Pervasive Computing2008，7，2： | 1 |
| 12 | A comparison between two different methods for solving KdV-Burgers equa- tion显示文摘 | Helal M A Mehanna M S | 2006 | Chaos Solitons Fractals2006，28，2： | 1 |
| 13 | Bovine viral diarrhea vi- rus infection in a dairy herd with high prevalence of persistent- ly infected calves显示文摘 | Helal M A Okamatsu H Tajima M | 2012 | Jpn J Vet Res2012，60，23： | 1 |
| 14 | Chromogenic and fluorogenic sensing of Cuz+ based on coumarin显示文摘 | Helal A Rashid M H O Choi C H | 2011 | Tetrahedron2011，67，15： | 1 |
| 15 | ILC-TCP:an interlayer collaboration protocol for TCP performance improvement in mobile and wireless environments显示文摘 | Chinta M Helal A Lee C | 2003 | Wireless Communications and Networking2003，2，： | 1 |
| 16 | Corrosion Control of Vanadium in Aqueous Solutions by Amino Acids 显示文摘 | EL-RABIEE M M HELAL N H EL-HAFEZ G M A | 2008 | Journal of Alloys and Compounds2008，459，12： | 1 |
| 17 | Optimal design of hybrid RO/MSF desalination plants Part I:Modeling and algorithms 显示文摘 | HELAL A M EL-NASHAR A M AL-KATHEERI E | 2003 | Desalination2003，154，1： | 1 |
| 18 | Immunohistochemical expressign of p53 and c - erbB2 proeins in breast cancer in Egypt显示文摘 | El- A Helal T Khalifa A Kamel AS | 2000 | Anticancer Res2000，20，3： | 1 |
| 19 | Imrnunohistochemical expression of p53 and c-erbB2 protein in breast cancer in Egypt 显示文摘 | EI-A Helal T Khalifa A Kamel A S | 2000 | AnticancerRes2000，20，3： | 1 |
| 20 | Mobile computing and database :Anything new?显示文摘 | Dunham M H Helal A | 1995 | SIGMOD Record1995，24，4： | 1 |
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