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| 1 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 2 | Isoformselective phosphoinositide 3-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia:a novel therapeutic approach显示文摘 | Niedermeier M Hennessy BT Knight ZA | 2009 | Blood2009，113，22： | 1 |
| 3 | The effect of the nitrification inhibitor dicyandiamide (DCD) on herbage production when applied at different times and rates in the autumn and winter显示文摘 | O'Connor PJ Hennessy D Brophy C O'Donovan M Lynch MB | 2012 | Agricultural Ecosystems & Environment2012，152，： | 1 |
| 4 | Mutually testing processes显示文摘 | Bernardi G Hennessy M | 2015 | ACM2015，11，21： | 1 |
| 5 | Carbon dioxide retention and oxygen desaturation during gastrointestinal endoscopy显示文摘 | Freeman M Hennessy JT Cass OW | 1993 | Gastroenterology1993，105，： | 1 |
| 6 | A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer显示文摘 | Berns K Horlings H M Hennessy B T | 2007 | Cancer Cell2007，12，4： | 1 |
| 7 | Acute vascular events associated with cisplatin therapy in malignant disease显示文摘 | Hennessy B O'Connor M Carney D N | 2002 | Ir Med J2002，95，： | 1 |
| 8 | The im- pact of simvastatin on pulmonary effectors of pseudomonas aeruginosa infection 显示文摘 | Hennessy E O'Callaghan J Mooij M J | 2014 | PLoS One2014，9，10： | 1 |
| 9 | Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity 显示文摘 | RAMKHELAWON B HENNESSY E J MENAGER M | 2014 | Nat Med2014，20，4： | 1 |
| 10 | Characterization of a naturally occurring breast cancer subset en- riched in epithelial-to-mesenchymal transition and stem cell char- acteristics 显示文摘 | Hennessy B T Gonzalez-Angulo A M Stemke-Hale K | 2009 | Cancer Res2009，69，10： | 1 |
| 11 | Prevalence of renal artery stenosis in flash puhnonary oedema: determination using gadolinium- enhanced MRA显示文摘 | McMahon C J Hennessy M Boyle G | 2010 | Eur J Intern Med2010，21，5： | 1 |
| 12 | Electromyography of arrow release in archery显示文摘 | HENNESSY M P PARKER A W | 1990 | Electromyography and Clinical Neurophysiology1990，，30： | 1 |
| 13 | Future of personalized medicine in oncology: a systems biology approach显示文摘 | GONZALEZ-ANGULO A M HENNESSY B T MILLS G B | 2010 | J Clin Oncol2010，28，16： | 1 |
| 14 | Analysis oforganophosphorus pesticides in dried ground ginseng root bycapillary gas chromatography mass spectrometry and flamephotometric detection显示文摘 | Wong J W Hennessy M K Hayward D G | 2007 | J Agric Food Chem2007，55，11： | 1 |
| 15 | Acute vascular events associated with cisplatin therapy in malignant disease显示文摘 | Hennessy B O'Connor M Carney DN | 2002 | Ir Med J2002，95，14： | 1 |
| 16 | Next-genera- tion roTOR inhibitors in clinical oncology; how pathway complexity informs therapeutic strategy显示文摘 | Wander S A Hennessy B T Slingerland J M | 2011 | J Clin Invest2011，121，4： | 1 |
| 17 | Targeting the epidermal growth facter receptor in epithelial ovrian cancer: current knowledge and future chanllenges 显示文摘 | Siwak DR Carey M Hennessy BT | 2009 | J Oncol2009，69，1： | 1 |
| 18 | Relevance of basalserum FSH to IVF outcome varies with patient显示文摘 | Sabatini L Zosmer A Hennessy E M | 2008 | Reprod Biomed Online2008，17，1： | 1 |
| 19 | Ovarian cancer 显示文摘 | Hennessy BT Coleman RL Markman M | 2009 | Lancet2009，374，： | 1 |
| 20 | Development of novel agents for ovarian cancer 显示文摘 | Hennessy BT Markman M | 2009 | Update On Cancer Therapeutics2009，3，3： | 1 |
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