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| 1 | Phage therapy: An alternative to antibiotics in the age of multi-drug resistance显示文摘The practice of phage therapy, which uses bacterial viruses(phages) to treat bacterial infections, has been around for almost a century. The universal decline in the effectiveness of antibiotics has generated renewed interest in revisiting this practice. Conventionally, phage therapy relies on the use of naturally-occurring phages to infect and lyse bacteria at the site of infection. Biotechnological advances have further expanded the repertoire of potential phage therapeutics to include novel strategies using bioengineered phages and purified phage lytic proteins. Current research on the use of phages and their lytic proteins against multidrug-resistant bacterial infections, suggests phage therapy has the potential to be used as either an alternative or a supplement to antibiotic treatments. Antibacterial therapies, whether phage-or antibiotic-based, each have relative advantages and disadvantages; accordingly, many considerations must be taken into account when designing novel therapeutic approaches for preventing and treating bacterial infection. Although much about phages and human health is still being discovered, the time to take phage therapy serious again seems to be rapidly approaching. | Derek M Lin Britt Koskella Henry C Lin | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，3： | 20 |
| 2 | Dopaminergic effects on in vitro osteogenesis显示文摘Multiple growth factors(e.g., BMP2, TGF-b1, FGF2) and isolated genes have been shown to improve osteoblastic proliferation and mineralization, advancing bone tissue engineering. Among these factors, both polydopamine(PDA) and dopamine(DA) monomer have recently been reported to increase osteoblast proliferation and mineralization in vitro. Although a well-characterized neurotransmitter, DA's role in the bone is unknown. We hypothesize that DA can directly act on osteoblasts, and examined whether osteoblasts express DA receptors that respond to exogenous DA. m RNAs and protein cell lysates were obtained from MC3T3-E1 cells during osteogenic differentiation phase. Reverse transcription polymerase chain reaction and western blot analysis were used to examine the expression of DA receptors, D1–D5. Dose-response effect and time course of DA treatment on cell proliferation, mineralization, and osteogenic differentiation were investigated at pre-determined days. Real-time PCR was performed to investigate whether DA affects osteogenic gene expression(ALP, BSP, OC, OSX, RUNX2, and Collagen1a2) with or without receptor antagonists(SCH233390 and GR103691). Two-way ANOVA was used for statistical analysis. All five DA receptors(D1, D2, D3, D4, and D5) m RNAs and proteins were expressed in MC3T3-E1 cells. DA treatment increased cell proliferation for up to 7 days(P, 0.05). Osteogenic mineralization was significantly greater in the DA-treated group than control group(P, 0.05). Finally, expression of all the osteogenic genes was inhibited by DA receptor antagonists for D1, D3, and D5. Our findings suggest that MC3T3-E1 osteoblasts express functional DA receptors that enhance proliferation and mineralization. PDA is not biologically inert and has important implications in orthopedic applications. Furthermore, osteoblast differentiation might be regulated by the nervous system, presumably during bone development, remodeling, or repair. | Dong Joon Lee Henry C Tseng Sing Wai Wong Zhengyan Wang Meng Deng Ching-Chang Ko | 2015 | Bone Research2015，3，3： | 3 |
| 3 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 4 | Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome显示文摘 | Mark Pimentel Evelyn J Chow Henry C Lin | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 5 | 便携式GC和GC\MS的发展之路显示文摘目前便携式和GC的发展方向是针对不同的分析需求来生产,它主要用于环保领域,其它如在工业卫生,在线工业过程监测等亦很有应用价值。本文给出了几种有代表性的便携式GVC的规格一览表。并阐述了该种仪器的现状及发展。 | Henry,C 王雄 | 1998 | 国外分析仪器技术与应用1998，，1： | 2 |
| 6 | Determination of protein secondary structure by Fourier transform infrared spectroscopy:a critical assessment显示文摘 | WITOLD K S HENRY H M DENNIS C | 1993 | Biochemistry1993，32，2： | 1 |
| 7 | Use of biosolids in the forest: Technology, economics and regulations显示文摘 | HENRY C L COLE D W | 1997 | Biomass and Bioenergy1997，13，4： | 1 |
| 8 | Phycocyanin: laser aetiviation cytotoxic effects and uptake in human athersclerotic plague显示文摘 | MORCOS N C BERNS M HENRY W L | 1998 | Lasers Surg Med1998，8，1： | 1 |
| 9 | Long-term follow-up of pseud-oexfoliation and the development of elevated intraocular pres-sure显示文摘 | Henry J C Krupin T Schmitt M | 1987 | Ophthalmology1987，94，： | 1 |
| 10 | Improved regeneration efficiency from mature embryos of barley cultivars显示文摘 | Akula C Akula A Henry R | 1999 | Biol Plant1999，42，4： | 1 |
| 11 | Angiotensin-converting enzyme inhibitionwith quinapril improves endothelial vasomotor dysfunction in patients with coronary arterydisease显示文摘 | John Mancini GB Gregory C Henry MS | 1996 | Circulation1996，94，3： | 1 |
| 12 | Tourmaline as a petrogenetic indicator mineral:an example from the staurolite-grade metapelites of NW Maine显示文摘 | Henry D J Guidotti C V | 1985 | American Mineralogist1985，70，： | 1 |
| 13 | Simultaneous determination of moisture,organic carbon,and total nitrogen by infrated reflectance spectrometry显示文摘 | Dalal R C Henry R J | 1986 | Soil Sci Soc Am J1986，50，： | 1 |
| 14 | Sirolimus- elu- ring versus uncoated stents in acute myocardial infarction 显示文摘 | SPAULDING C HENRY P TEIGER E | 2006 | N Engl J Med2006，，： | 1 |
| 15 | Stratal slicing,part II:Real 3-D seismic data显示文摘 | Zeng Hongliu Stephen C Henry John P Riola | 1998 | Geopgysics1998，63，2： | 1 |
| 16 | Developing Performance - Oriented Models forUniversity Resource Allocation 显示文摘 | CASPER C A HENRY M S | 2001 | Research in Higher Education2001，42，3： | 1 |
| 17 | Influence of environmental abiotic factors on the content of saponins in plants 显示文摘 | Szakiel A paczkowski C Henry M | 2011 | Phytochem Rev2011，10，： | 1 |
| 18 | Fundamentals of alternative dispute resolution processes in construction显示文摘 | Sai On Cheung Henry C H Suen Tsun-Ip Lam | 2002 | Journal of Construction Engineering and Management2002，128，2： | 1 |
| 19 | Estimation of rela- tive bioavailability of nutrients using SAS procedures显示文摘 | Littell R C Henry P R Lewis A J | 1997 | Jour- nal of Animal Science1997，75，10： | 1 |
| 20 | Strategies for reducing foundry emissions 显示文摘 | Fox J R Adamovits M Henry C | 2002 | American Foundry Society Transactions2002，110，： | 1 |
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