|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | Influence of microstructure on the dielectric and piezoelectric properties of lead Zieconate titanate-polymer composites显示文摘 | LEE H G KIM Ho Gi | 1989 | J Am ceram soc1989，72，6： | 2 |
| 3 | 显示文摘 | Gong H Wilk G D | 2002 | Appl Phys Lett2002，81，： | 1 |
| 4 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 5 | Visualization and spectroscopy of a Metal-Molecule-Metal bridge显示文摘 | Nazin G V Qiu X H Ho W | 2003 | Science2003，302，： | 1 |
| 6 | Random laser action in semiconductor powder显示文摘 | ZHAO Y G HO S T | 1999 | Phys Rev Lett1999，82，11： | 1 |
| 7 | Effects of electrical stimulation and postmortem storage on changes in titin, nebulin, desmin, troponin- T, and muscle uhrastructure in Bos indicus crossbred cattle 显示文摘 | Ho C Y Stromer M H Rouse G | 1997 | Journal of Animal Science1997，75，2： | 1 |
| 8 | IL-27 directly restrains lung tumorigenicity by suppressing cyclooxygenase-2-mediated activities 显示文摘 | Ho M Y Leu S J Sun G H | 2009 | J Immunol2009，183，10： | 1 |
| 9 | Visualization and spectroscopy of a metal-molecule-metal bridge显示文摘 | Nazin G V Qiu X H Ho W | 2003 | Science2003，302，： | 1 |
| 10 | An overview of the femtocell concept显示文摘 | Claussen H Ho L T W Samuel L G | 2008 | Bell Labs Technical Journal2008，13，1： | 1 |
| 11 | Adv Mater 显示文摘 | Gao J Li L Ho P L Mak G C Gu H Xu B | 2006 | 18(23): 3145-31482006，18，23： | 1 |
| 12 | Colorimetric and fluorometric detection of nucleic acidsusing cationic polythiophene derivatives显示文摘 | Ho H A Boissinot M Bergeron M G | 2002 | Angewandte Chemie International Edition2002，41，9： | 1 |
| 13 | Visualization and spectroscopy of a metal-molecule-metal bridge 显示文摘 | Nazin G V Qiu X H Ho W | 2003 | Science2003，302，： | 1 |
| 14 | Random laser action in semiconductor powder显示文摘 | Cao H Zhao Y G Ho S T | 1999 | Phys Rev Lett1999，82，11： | 1 |
| 15 | Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days 显示文摘 | Wang H L Ichihara G ho H et ol | 2002 | Toxicol Sci2002，67，1： | 1 |
| 16 | Similarity of the phenotypie patterns associated with BRAF and KRAS mutations in eolorectal neoplasia显示文摘 | Yuen S T Davies H Chan T L Ho J W Bignell G R Cox C | 2002 | Cancer Res2002，62，： | 1 |
| 17 | Extracting,linking and integrating data from public sources:a financial case study显示文摘 | Burdick D Hernández M A Ho H Koutrika G Krishnamurthy R Popa L Sranoi I Vaithyanathan S Das S R | | 0，，03： | 1 |
| 18 | Random Laser Action in Semiconductor Powder显示文摘 | Cao H Zhao Y G Ho S T | 1999 | Phys Rev Lett1999，82，： | 1 |
| 19 | Development of a pro- cess mining system for supporting knowledge discovery in a supply chain network显示文摘 | H C W Lau G T S Ho Y Zhao | 2009 | International Journal of Production Economics2009，122，1： | 1 |
| 20 | Long -term r i sk of incident v e r t e b r a 1 f r a c t u r e s 显示文摘 | Ca u 1 e y JA Ho c h b e r g MC L u i LY e t a 1 | | JAMA0，298，23： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员