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| 1 | Membrane-bound mucins and mucin terminal glycans expression in idiopathic or Helicobacter pylori, NSAID associated peptic ulcers显示文摘AIM:To determine the expression of membrane-bound mucins and glycan side chain sialic acids in Helicobacter pylori(H.pylori)-associated,non-steroidal inflammatory drug(NSAID)-associated and idiopathic-gastric ulcers.METHODS:We studied a cohort of randomly selected patients with H.pylori(group 1,n=30),NSAID(group 2,n=18),combined H.pylori and NSAID associated gastric ulcers(group 3,n=24),and patients with idiopathic gastric ulcers(group 4,n=20).Immunohistochemistry for MUC1,MUC4,MUC17,and staining for Erythrina cristagalli agglutinin and Sambucus nigra agglutinin(SNA)lectins was performed on sections from the ulcer margins.RESULTS:Staining intensity of MUC17 was higher in H.pylori ulcers(group 1)than in idiopathic ulcers(group4),11.05±3.67 vs 6.93±4.00 for foveola cells,and10.29±4.67 vs 8.00±3.48 for gland cells,respectively(P<0.0001).In contrast,MUC1 expression was higher in group 4 compared group 1,9.89±4.17 vs 2.93±5.13 in foveola cells and 7.63±4.60 vs 2.57±4.50 for glands,respectively(P<0.0001).SNA lectin staining was increased in group 4,in parallel to elevated MUC1expression,indicating more abundantα2-6 sialylation in that group.CONCLUSION:Cytoplasmic MUC17 staining was sig-nificantly decreased in the cases with idiopathic ulcer.The opposite was observed for both MUC1 and SNA lectin.This observation may reflect important pathogenic mechanisms,since different mucins with altered sialylation patterns may differ in their protection efficiency against acid and pepsin. | Yaron Niv Doron Boltin Marisa Halpern Miriam Cohen Zohar Levi Alex Vilkin Sara Morgenstern Vahig Manugian Erica St Lawrence Pascal Gagneux Sukhwinder Kaur Poonam Sharma Surinder K Batra Samuel B Ho | 2014 | World Journal of Gastroenterology2014，20，40： | 5 |
| 2 | Adaptive fuzzy sliding mode control with chattering elimination for nonlinear SISO systems 显示文摘 | Ho H F Wong Y K Rad A B et | 2009 | Simulation Modelling Practice and Theory2009，17，7： | 1 |
| 3 | Alleviation effects of magnesium on copper toxicity and accumulation in grape- vine roots evaluated with biotic ligand models 显示文摘 | Chen B C Ho P C Juang K W | 2013 | Eco- toxicology2013，22，1： | 1 |
| 4 | Burst-shear flexiondistraction injuries of the lumbar spine 显示文摘 | JEANNERET B HO P K MAGERL F | 1993 | J Spinal Disord1993，6，6： | 1 |
| 5 | Crystal morphological investigation in thin films of poly(aryl ether ketone ketone) having a meta-linka_ge显示文摘 | Gardner K H Hsiao B S Ho R M | 1997 | Polymer1997，20，： | 1 |
| 6 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 7 | Changing epidemiological lea tures of cardiac failure显示文摘 | Kannel W B Ho K Thorn T | 1994 | British Heart Journal1994，72，2： | 1 |
| 8 | Effects of the addition of titania on the thermal characterization of alumina - supported palladium显示文摘 | Wang C B Lin H K Ho C M | 2002 | J Mole Catal A2002，180，： | 1 |
| 9 | Changing epidemiological fea- tures of cardiac failure 显示文摘 | KANNEL W B HO K THOM T | 1994 | Br Heart J1994，72，2： | 1 |
| 10 | An in situ heater for a phase-change-material-based actuation system 显示文摘 | Sant H J Ho T Gale B K | 2010 | Journal of Mieromeehanics and Mieroengineering2010，20，8： | 1 |
| 11 | Predicting survival in heart failure case and control subjects by use of fully automated methods for deriving nonlinear and conventional indices of heart rate dynamics显示文摘 | Ho K K Moody G B Peng C K | 1997 | Circulation1997，96，3： | 1 |
| 12 | Adhesion and wear resistance of nitrided and TiN coated low alloy sreels 显示文摘 | Spies H J Larisch B Ho ck K | 1995 | Surface and Coationgs Technology1995，7475，： | 1 |
| 13 | Evidence for involvement of cyclic GMP phosphodiesterase in morphine tolerance 显示文摘 | Burton C K Ho I K Hoskins B | 1990 | J Pharmacol Exp Ther1990，252，1： | 1 |
| 14 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 15 | TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathway显示文摘 | Nguyen M H Ho J M Beattie B K | | 0，，35： | 1 |
| 16 | The epidemiology of heart failure: the Framingham Study 显示文摘 | Ho K K Pinsky J L Kannel W B | 1993 | J Am Coil Cardiol1993，22，4： | 1 |
| 17 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 18 | An effective architecture for learning and evolving flexible job-shop schedules显示文摘 | Ho N B Tay J C Lai E M K | 2007 | European Journal of Operational Research2007，179，2： | 1 |
| 19 | Robust fuzzy tracking control for robotic manipulators显示文摘 | Ho H F Wong Y K Rad A B | | 0，，07： | 1 |
| 20 | Numerical and experimental investigations on the gas temperature deviation in a large scale,advanced low NOx,tangentially fired pulverized coal boiler显示文摘 | HO Y P SE H B YOUNG J K | 2013 | Fuel2013，104，2： | 1 |
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