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| 1 | Chronic antiepileptic drug use and functional network efficiency: A functional magnetic resonance imaging study显示文摘AIM To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug(AED) treatment.METHODS The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A 'low risk' category(lamotrigine or levetiracetam, n=16), an 'intermediate risk' category(carbamazepine, oxcarbazepine, phenytoin, or valproate, n=34) and a 'high risk' category(topiramate, n=5). Brain connectivity was assessed using resting state functional magnetic resonance imaging and graph theoretical network analysis. The Computerized Visual Searching Task was used to measure central information processing speed, a common cognitive side effect of AED treatment. RESULTS Central information processing speed was lower in patients taking AEDs from the intermediate and high risk categories, compared with patients from the low risk category. The effect of risk category on global efficiency was significant(P < 0.05, ANCOVA), with a significantly higher global efficiency for patient from the low category compared with the high risk category(P < 0.05, post-hoc test). Risk category had no significant effect on the clustering coefficient(ANCOVA, P > 0.2). Also no significant associations between information processing speed and global efficiency or the clustering coefficient(linear regression analysis, P > 0.15) were observed. CONCLUSION Only the four patients taking topiramate show aberrant network measures, suggesting that alterations in functional brain network organization may be only subtle and measureable in patients with more severe cognitive side effects. | Tamar M van Veenendaal Dominique M IJff Albert P Aldenkamp Richard H C Lazeron Paul A M Hofman Anton J A de Louw Walter H Backes Jacobus F A Jansen | 2017 | World Journal of Radiology2017，9，6： | 2 |
| 2 | The use of biological activated carbon filtration for the removal of natural organic matter and organic micropollutants from water 显示文摘 | J P van der Hoek J A M H Hofman A Graveland | 1999 | Water Science and Technology1999，40，9： | 1 |
| 3 | The Rotterdam Study:2010 objectives and design update显示文摘 | HOFMAN A BRETELER M M VAN DUIJN C M | 2009 | Eur J Epidemiol2009，24，9： | 1 |
| 4 | Duration of antihypertensive drug use and risk of dementia: A prospective cohort study 显示文摘 | M D M Haag A Hofman P J Koudstaal | 2009 | Neurology2009，，72： | 1 |
| 5 | Long term capacity of biological activated carbon filtration for organics removal 显示文摘 | Bonne P A C Hofman J A M H van der Hoek J P | 2002 | Water Supply2002，2，1： | 1 |
| 6 | Coronary calcification improves cardiovascular risk prediction in the elderly显示文摘 | Oudkerk M Hofman A | 2005 | Circulation2005，112，4： | 1 |
| 7 | Atherosclerosis,apolipoprotein E,and prevalence of dementia and Alzheimer's disease in the Rotterdam Study显示文摘 | Hofman A Ott A Breteler M | | 0，，： | 1 |
| 8 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study 显示文摘 | Bos M J Koudstaal PJ Hofman A | 2006 | Stroke2006，37，6： | 1 |
| 9 | Low temperature conditioning before cold disinfestation improves 'Hass' avocado fruit quality显示文摘 | Hofman P J Stubbings B A Adkins M F | 2003 | Postharvest Biology and Technology2003，28，1： | 1 |
| 10 | Migraine as a risk factor for subclinical brain lesions显示文摘 | Kruit M C van Buchem M A Hofman P A | 2004 | JAMA2004，291，： | 1 |
| 11 | Predictive value of noninvasive measures of atherosclerosis for incident myocardial infarction:the Rot-terdam Study显示文摘 | Mvander I Bots M Hofman A | 2004 | Circulation2004，109，： | 1 |
| 12 | Thiazide diureticsand the risk for hip fracture显示文摘 | Schoofs MW Van Der Klift M Hofman A | 2003 | Ann Intern Med2003，139，6： | 1 |
| 13 | GDF5 single nucleotide polymorr phism rs143383 is associated with lumbar disc degeneration inNorthern European women显示文摘 | Williams F M Popham M Hart D J de Schepper E Bierma Zeinstra S Hofman A | 2011 | Arthritis Rheum2011，63，： | 1 |
| 14 | Uric acid is a risk factor for myocardial infarction and stroke: the Rotterdam study 显示文摘 | Bos M J Koudstaal PJ Hofman A | 2006 | Stroke2006，37，6： | 1 |
| 15 | Decreased glomerular filtration rate is a risk factor for hemorrhagic but not for ischemic stroke : the Rotterdam Study 显示文摘 | Bos M J Koudstaal PJ Hofman A | 2007 | Stroke2007，38，： | 1 |
| 16 | The Rotterdam Study:objectives and design update显示文摘 | HOFMAN A BRETELER M M VAN DUIJN C M | 2007 | Eur J Epidemiol2007，22，11： | 1 |
| 17 | Uric is a risk factor for myocardial infarction and stroke: the rotterdam study显示文摘 | Bos M J Koudstaal P J Hofman A | 2006 | Stroke2006，37，6： | 1 |
| 18 | Lipopro-tein-associated phospholipase A2 activity is associated withrisk of coronary heart disease and ischemic stroke : theRotterdam Study 显示文摘 | Oei H H van der Meer I M Hofman A | 2005 | Circulation2005，111，5： | 1 |
| 19 | The Rotterdam Study:2010objectives and design update显示文摘 | HOFMAN A BRETELER M M VAN DUIJN C M | 2009 | Eur J Epidemiol2009，24，9： | 1 |
| 20 | Cell cycle phase-specific survival of CD95 ligand-challenged Jurkat cells:upregulation of heatshock response显示文摘 | Parr T B Hofman F M Kiener P A | 2001 | Cell Immunol2001，211，： | 1 |
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