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| 1 | Serial imaging of human embryonic stem-cell engraftment and teratoma formation in live mouse models显示文摘表示为基于 radiopharmaceutical 的成像为生物体之发光成像或 HSV1 thymidine kinase (HSV1-TK ) 编码任何一个萤火虫酶(fLuc ) 的记者 transgene 的 lentiviral 向量的二种新类型被构造监视人的胚胎的干细胞(hESC ) 在在移植以后的活老鼠的嫁接和增长。任何一个 transgene 的组成的表示没在文化改变 hESCs 的性质。我们下次在 SCID 鼠标监视了 teratomas 的形成到测试(1 ) 是否修改基因的 hESCs 维持他们的发展 pluripotency,并且(2 ) 是否支撑了记者基因表示,允许 noninvasive,在一个活鼠标模型的 hESC 衍生物的整个身体的成像。我们在接种以后从修改基因的房间以及野类型的 hESCs 2-4 月的两种类型观察了 teratoma 形成。用一个光成像系统,从 fLuc-transduced hESCs 的生物体之发光容易在在摸得出的肿瘤能被检测以前,长忍受 teratomas 的老鼠被检测。开发一个 noninvasive 成像方法对诊所更容易地可译,我们也利用了 HSV1-TK 和它的特定的底层, 1-(2 鈥 ? deoxy-2 鈥 ?fluoro- 尾 - D-arabinofuranosyl )-5-[125I]iodouracil ([125I ] FIAU ) ,记者 / 探查对。在全身的管理以后,[125I ] FIAU 是仅仅由编码 transgene 的 HSV1-TK 酶的 phosphorylated 并且在 transduced 以内保留(并且移植) 房间,由单个光子的排放允许敏感、量的成像计算了断层摄影术。象这些那样的 Noninvasive 成像方法可以使我们能在实时接受者以内重复地监视移植人的干细胞的存在和分发在上一通过记者基因的表达式长期。 | Martin G Pomper Holly Hammond Xiaobing Yu Zhaohui Ye Catherine A Foss Doris D Lin James J Fox Linzhao Cheng | 2009 | Cell Research2009，19，3： | 9 |
| 2 | Gastric cancer in Alaska Native people: A cancer health disparity显示文摘AIM To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native(AN) people. METHODS A retrospective analysis of the Alaska Native Medical Center patient database was performed. Patient history, clinical, pathological, response to treatment and patient outcomes were collected from one-hundred and thirty-two AN gastric cancer patients. The Surveillance, Epidemiology and End Result database 18 was used to collect comparison United States non-Hispanic White(NHW) and AN gastric cancer patient data between 2006-2014.RESULTS AN gastric cancer patients have a higher incidence rate, a poorer overall survival, and are diagnosed at a significantly younger age compared to NHW patients. AN patients differ from NHW patients in greater prevalence of non-cardia, diffuse subtype, and signet ring cell carcinomas. AN females were more likely to be diagnosed with later stage cancer, stage IV, compared to AN males. Diminished overall survival was observed among AN patients with increasing stage, O+ blood type, < 15 lymph nodes examined at resection, and no treatment. This study is the first report detailing the clinicopathologic features of gastric cancer in AN people with outcome data.CONCLUSION Our findings confirm the importance of early detection, treatment, and surgical resection for optimizing AN patient outcomes. Further research on early detection markers are warranted. | Holly A Martinson Nancy J Shelby Steven R Alberts Matthew J Olnes | 2018 | World Journal of Gastroenterology2018，24，25： | 6 |
| 3 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 4 | 4号染色体短臂微卫星多态性与鼻咽癌相关性的研究显示文摘鼻咽癌(NPC)是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中,那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中两个关键步骤相关的遗传变异,即EB病毒持续性感染鼻咽部上皮细胞和鼻咽癌的形成。我们在广西梧州市及苍梧县鼻咽癌高发区收集汉族鼻咽癌患者350例、EB病毒壳抗原IgA抗体阳性者(IgA/VCA+)288例和EB病毒壳抗原IgA抗体阴性者(IgA/VCA—)346例。对先前鼻咽癌家系研究显示的鼻咽癌易感区4号染色体短臂(4p15.1~q12)进行了微卫星精细扫描,在18Mb的范围内选择34个微卫星标记,包括319个等位基因,对其进行基因分型。比较分析NPC组和IgA/VCA+组等位基因频率结果显示,9个等位基因与鼻咽癌呈相关,其中5个为易感等位基因(OR=1.51~5.36,P=0.01~0.03),4个为限制性等位基因(OR值为0.3~0.71,P值为0.02~0.045)。比较分析IgA/VCA+组和IgA/VCA-组及比较所有IgA/VCA+者(包括NPC患者)和IgA/VCA-者等位基因频率的结果显示,12个等位基因与EB病毒壳抗原IgA抗体持续存在相关,其中3个在两组比较中均呈显著相关。等位基因D4S3241~136(P=0.004,OR=1.9,95%CI=1.2~3.0)和D4S3347-213(P=0.001,OR=1.6,95%CI=1.2~2.1)可增加EB病毒IgA/VCA抗体形成的危险,为易感基因;而等位基因D4S174.202(P=0.001,OR=0.5,95%CI=0.3~0.7)可限制IgA/VCA抗体的形成。但上述结果经多因素比较校正后,均失去相关性。结果不能确定该区域与非家族性鼻咽癌的形成相关,但本研究却提供了进一步发现鼻咽癌相关基因的研究模式。有关4号染色体短臂与EB病毒慢性持续感染及鼻咽癌的形成仍值得进一步深入研究。 | 郭秀婵 O’BRIEN Stephen J WINKLER Cheryl SCOTT Kevin HUTCHESON Holli DAVID Victor KESSING Bailey 郑裕明 廖建 刘彦 GUY de The 曾毅 | 2006 | 遗传2006，28，7： | 2 |
| 5 | The albumin cobalt binding test:analytical performance of a new automated chemistry 0assay for the detection of ischemia modified albumin(IMA)显示文摘 | Fagan G J Hollie Wayment Deborah L | 2002 | Clin Leg Assay2002，25，5： | 1 |
| 6 | Aspartame consumption in relation to childhood brain tumour risk: results from a case-control study显示文摘 | GURNEY J G POGODA J M HOLLY E A | 1997 | J Nat Cancer Inst1997，89，14： | 1 |
| 7 | A study of south-east Asia tourist-per-ceptions of service quality in the San Francisco Bay area显示文摘 | Holly H J | 2002 | Journal of Travel and Tourism Marketing2002，13，3： | 1 |
| 8 | Guidance molecules in axon regeneration显示文摘 | Giger R J Hollis ⅡE R Tuszynski M H | | 0，，07： | 1 |
| 9 | Lumpectomy with or without postoperative radiotherapy for breast cancer with favorable prognostic features : results of a randomized study 显示文摘 | Holli K Saaristo R Isola J | 2001 | Br J Cancer2001，84，2： | 1 |
| 10 | Persistence of Legionella pneumophila in a hospital's water system: a 13 -year survey显示文摘 | Rangel-Frausto MS Rhomberg P Hollis R J | 1999 | Infect Control Hosp Epidemiol1999，20，： | 1 |
| 11 | X-33 aerodynamic computations and comparisons with windtunnel data显示文摘 | Hollis B R Thompson R A Murphy K J etal | 2001 | Journal of Spacecraft and Rockets2001，38，5： | 1 |
| 12 | Timing of gold and crustal evolution of the Palaeuzoic south central Andes,NW Argentina-implications for the endowment of orogenic belts显示文摘 | Frank P Bierlein Holly J Stein Beatfiz Coira Peter Reynolds | 2006 | Earth and Planetary Science Letters2006，245，： | 1 |
| 13 | Possible autocrine growth stimulation of cholesteatoma epithelium hy transforming growth factor alpha 显示文摘 | Schulz P Bujla J Holly A | 1993 | Am J Otolaryngol1993，14，2： | 1 |
| 14 | Bacteria in healthy potato tissue 显示文摘 | Hollis J P | 1951 | Phytopathology1951，，41： | 1 |
| 15 | Distinct sites of insulin-like growth factor (IGF)-Ⅱ expression and localization in lesioned rat brain:possible roles of IGF binding proteins (IGFBPs) in the mediation of IGF-Ⅱ activity显示文摘 | Walter H J Berry M Hill DJ Cwyfan-Hughes S Holly JM Logan A | 1999 | Endocrinology1999，140，1： | 1 |
| 16 | Spectroscopic properties of Er3 + and Tm3 +in tellurite glasses显示文摘 | McDongall J Hollis D B Payne M J P | 1996 | Phys Chem Glasses1996，37，25： | 1 |
| 17 | Minimally invasive lumbar fusion 显示文摘 | Foley K T Holly L T Schwender J D | 2003 | Spine2003，15，： | 1 |
| 18 | Possible autocrine growth stimulation of cholesteatoma epithelium by transforming growth factor alpha 显示文摘 | Schulz P Bujia J Holly A | 1993 | Am J Otolaryngol1993，14，2： | 1 |
| 19 | Effect of frameless stereotaxy on the accuracy of C1-2 transarticular screw placement显示文摘 | Bloch O Holly LT Park J | 2001 | J Neurosurg2001，95，1： | 1 |
| 20 | Numerical physical framework for mobil-bed modeling显示文摘 | Holly F M Jr Rahuel J L | 1990 | J Hydraulic Research1990，28，4： | 1 |
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