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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 3 | 心房颤动——当今面临的挑战显示文摘在过去数年里,临床和科撞方面对心房颤动(房颤)的关注明显增加,有关这一论题的出版物数量迅速、稳定的增长就是证明。虽然已有一些新方法治疗遮一心律失常一但大多数房颤患者仍然不得不忍受这一心律失常,包括其不良后果和症状,房颤无疑是虽迫切需要有更好治疗方法的一种心律失常。为了达到这一目的,就需要更深刻地认识房颤的机制.以便开发直接影响这一基础病理生理机制的治疗措施。 | Olsson SB Hansson A Hedin E Holm M Ingemansson M Johansson R Meurling C Pehrson S Roijer A Yuan S 方丕华 | 1997 | 中华心律失常学杂志1997，1，1： | 3 |
| 4 | Mapping aboveground biomass and its prediction uncertainty using LiDAR and field data, accounting for tree-level allometric and LiDAR model errors显示文摘Background: The increasing availability of remotely sensed data has recently challenged the traditional way of performing forest inventories, and induced an interest in model-based inference. Like traditional design-based inference, model-based inference allows for regional estimates of totals and means, but in addition for wall-to-wall mapping of forest characteristics. Recently Light Detection and Ranging(LiDAR)-based maps of forest attributes have been developed in many countries and been well received by users due to their accurate spatial representation of forest resources. However, the correspondence between such mapping and model-based inference is seldom appreciated. In this study we applied hierarchical model-based inference to produce aboveground biomass maps as well as maps of the corresponding prediction uncertainties with the same spatial resolution. Further, an estimator of mean biomass at regional level, and its uncertainty, was developed to demonstrate how mapping and regional level assessment can be combined within the framework of model-based inference.Results: Through a new version of hierarchical model-based estimation, allowing models to be nonlinear, we accounted for uncertainties in both the individual tree-level biomass models and the models linking plot level biomass predictions with LiDAR metrics. In a 5005 km2 large study area in south-central Sweden the predicted aboveground biomass at the level of 18 m×18 m map units was found to range between 9 and 447 Mg·ha^-1. The corresponding root mean square errors ranged between 10 and 162 Mg·ha^-1. For the entire study region, the mean aboveground biomass was 55 Mg·ha^-1 and the corresponding relative root mean square error 8%. At this level 75%of the mean square error was due to the uncertainty associated with tree-level models.Conclusions: Through the proposed method it is possible to link mapping and estimation within the framework of model-based inference. Uncertainties in both tree-level biomass models and models linking plot level biomass with LiDAR data are accounted for, both for the uncertainty maps and the overall estimates. The development of hierarchical model-based inference to handle nonlinear models was an important prerequisite for the study. | Svetlana Saarela AndréWästlund Emma Holmström Alex Appiah Mensah Sören Holm Mats Nilsson Jonas Fridman Göran Ståhl | 2020 | Forest Ecosystems2020，7，3： | 3 |
| 5 | Reducing the morbidity from extravasation injuries显示文摘 | Khan M S Holmes J D | 2002 | Ann Plast Surg2002，48，6： | 3 |
| 6 | The Bioconversion of (3RS,E)-and (3RS, Z)-nerolidol into oxygenated products by streptomyces cinnamonensis 显示文摘 | Holmes D S Ashworth D M | 1990 | Helv Chim Acta1990，73，2： | 2 |
| 7 | Platelet storage lesion in second-generation containers: correlation with platelet ATP levels显示文摘 | Holme S Heaton WA Courtright M | 1987 | Vox Sang1987，53，4： | 1 |
| 8 | Compensatory growth in the rainbow trout, Saimo gairdneri Richardson 显示文摘 | Dobson S H Holmes R M | 1984 | J Fish Biol1984，25，： | 1 |
| 9 | A review of recent progress towards development of a formulated microbound diet for mud crab, Scylla serrata, larvae and their nutritional requirements显示文摘 | HOLME M H ZENG C S SOUTHGATE P C | 2009 | Aquaculture2009，286，： | 1 |
| 10 | Polymer Supported Chromium Porpbyrin as Catalyst for Polycarbonate Formation in Supercritical Carbon Dioxide显示文摘 | Stamp L M Mang S A Holmes A B | 2001 | Chem Commun2001，30，： | 1 |
| 11 | Self- complementary oligopeptide matrices support mammalian cell attachment显示文摘 | Zhang S Holmes T C Dipersio C M | 1995 | Biomaterials1995，16，： | 1 |
| 12 | Temporal analysis of shoreline recession and accretian显示文摘 | Dolan R Fenster M S Holme S J | 1991 | Journal of Coastal Research1991，7，3： | 1 |
| 13 | Compensatory growth in the rainbow trout,Salmo gairdneri Richardson显示文摘 | Dobson S H Holmes R M | 1984 | J Fish Biol1984，，25： | 1 |
| 14 | Betaine and folate status as cooperative determinants of plasma homocysteine in humans显示文摘 | HOLM PI UELAND P M VOLLSET S E etal | 2005 | Arterioscler Thromb Vasc Biol2005，25，2： | 1 |
| 15 | Recombi- nation is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratorysyn- drome viruses in China显示文摘 | Shi M Holmes E C Brar M S Leung F C | 2013 | J Virol2013，87，10： | 1 |
| 16 | Staphylococcus aureus isolates carrying Panton-Valentine leukocidin genes in England Wales:frequency,characterization and association with clinical disease显示文摘 | Holmes A Ganner M McGuane S | 2005 | J Clin Microbiol2005，43，5： | 1 |
| 17 | 1997 Volvo Award winner in biomechanical studies, Kinematic behavior of the porcine lum- bar spine:a chronic lesion model显示文摘 | Kaigle A M Holm S H Hansson T H | 1997 | Spine1997，22，24： | 1 |
| 18 | Methanol to Gasoline over Zeolite H-ZSM-5 : Improved Catalyst Performance by Treatment with NaOH 显示文摘 | Bjogen M Joensen F Holm M S | 2008 | Appl Catal A2008，345，1： | 1 |
| 19 | Compensatory growth in the rainbow trout, Salmo gaivdnevi Richardson显示文摘 | DOBSON S H HOLM R M | 1984 | J Fish Biol1984，25，6： | 1 |
| 20 | Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis 显示文摘 | DOESSING S HEINEMEIER K M HOLM L | 2010 | J Physiol2010，，2： | 1 |
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