|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 2 | Novel process for low temperature crystallization of a-SiC: H for optoelectronic applications显示文摘 | Hossain M Perez J R S Rivera J M R | 2009 | Journal of Materials Science2009，20，： | 1 |
| 3 | Carburization behavior of HK40 steel in furnaces used for ethylene production 显示文摘 | D J Hall M K Hossain and R F Atkinson | 1982 | High Temperature High Pressure1982，14，： | 1 |
| 4 | Assessing Residual Stress Development and Stress Relaxation in Restrained Concrete Ring Specimens显示文摘 | Hossain A B Weiss J | 2004 | Cement & Concrete Composite2004，26，： | 1 |
| 5 | Results of non-operative treatment following hip fracture compared to surgi- cal intervention显示文摘 | HOSSAIN M NEELAPALA V ANDREW J G | 2009 | Injury2009，40，4： | 1 |
| 6 | Novel process for low temperature crystallization of α-SIC: H for optoelectronic applications显示文摘 | Hossain M Perez J R S Rivera J M R | 2009 | Journal of Materials Science2009，20，1： | 1 |
| 7 | Hydration in high-performance cementitious systems containing vitreous calcium aluminosilicate or silica fume 显示文摘 | Neithalath N Persun J Hossain A | 2009 | Cement and Concrete Research2009，39，： | 1 |
| 8 | Mapping the dynamics of knowledge base of innovations of R&D in Bangladesh :triple helix perspective显示文摘 | Hossain M D Moon J Kang H Y | 2012 | Scientometrics2012，90，1： | 1 |
| 9 | Neuroprotection by scatter factor/hepatocyte growth factor and FGF-1 in cerebeliar granule neurons is phosphatidylinositol 3-kinase/akt-dependent and MAPK/CREB-in-dependent显示文摘 | Hossain M A Russell J C Gomez R | 2002 | Journal of Neurochemistry2002，81，2： | 1 |
| 10 | An optimized forwardplanning technique for intensitymodulated radiation therapy显示文摘 | Xiao Y Galvin J Hossain M | 2000 | Med Phys2000，27，9： | 1 |
| 11 | Water-cement ratiometer: Preliminary results 显示文摘 | HOSSAIN M KOELLIKER J IBRAHIM H | 1996 | J Transport Res Board1996，1532，： | 1 |
| 12 | Car- rier generation and collection in CdS/CdSe-sensitized SnO2 solar cells exhibiting unprecedented photocur- rent densities 显示文摘 | HOSSAIN M A JENNINGS J R KOH Z Y | 2011 | ACS Nano2011，5，4： | 1 |
| 13 | Nipah virus en- cephalitis reemergence, Bangladesh显示文摘 | Hsu V P Hossain M J Parashar U D | 2004 | Emerg Infect Dis2004，10，： | 1 |
| 14 | Robust partial feedback linearizing stabilization scheme for three-phase grid-connected photovoltaic systems显示文摘 | Mahmud M A Pota H R Hossain M J | 2014 | IEEE Journal of Photovoltaics2014，4，1： | 1 |
| 15 | Antineoplas- tic activity of N-(2-hydroxybenzylidene) 2'-hydroxyphe- nylimine aqua nickel( II ) complex on ehrlich ascites carcinoma (EAC) in Swiss albino mice 显示文摘 | Hossain I A Khanam J A Jesmin M | 2016 | Exp Toxieol Pathol2016，68，1： | 1 |
| 16 | Serum immunoglobulins and white blood cells status of drug addicts: influence of illicit drugs and sex habit显示文摘 | Islam SK Hossain K J Kamal M | 2004 | Addict Biol2004，9，： | 1 |
| 17 | Benefits of a pediatric an-timicrobial stewardship program at a children′s hospital显示文摘 | Di Pentima MC Chan S Hossain J | 2011 | Pediatrics2011，128，6： | 1 |
| 18 | Delayed presenlatinn of post-traumatic aneurysm of the posterior inferior cerebellar arlery in a pa-tient with spinal cord injury显示文摘 | Hossain M Brown J McLean AN | 2002 | Spinal Cotxt2002，40，6： | 1 |
| 19 | VAR planning with tuning of STATCOM in a DG integrated industrial system 显示文摘 | T Aziz M J Hossain T K Saha | 2013 | IEEe Transactions on Power Delivery2013，28，2： | 1 |
| 20 | Comparative study of total phenolics, flavonoids contents and evaluation of antioxidant and antimicrobial activities of different polarities fruits crude extracts of Datura metel L显示文摘 | HOSSAIN M A KALBANI M S A FARSI S A J A | 2014 | Asian Pacific Journal of Tropical Disease2014，4，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员