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| 1 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 2 | Association of types of diabetes and insulin dependency on birth outcomes显示文摘BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy outcomes.AIM To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes status.METHODS Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant mortality.Confounders included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm birth.Bivariate and multivariate logistic regression assessed differences in outcomes by diabetes status.RESULTS Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic women.Women with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic women.CONCLUSION Diabetes is associated with the poor birth outcomes.Clinical management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes. | Pamela K Xaverius Steven W Howard Deborah Kiel Jerry E Thurman Ethan Wankum Catherine Carter Clairy Fang Romi Carriere | 2022 | World Journal of Clinical Cases2022，10，7： | 2 |
| 3 | Adaptive immune responses to Acanthamoeba cysts显示文摘 | McClellan K Howard K Mayhew E Niederkorn J Alizadeh H | 2002 | Exp Eye Res2002，75，： | 1 |
| 4 | Release of pro-teins and peptides from fusion proteins using a recombinantplant virus proteins显示文摘 | Parks T D Leuther K K Howard E D | 1994 | Anal Biochem1994，216，2： | 1 |
| 5 | Corn as a production system for human and animal vaccines显示文摘 | Streatfield S J Lane J R Brooks C A Barker D K Poage M L Mayor J M Lamphear B J Drees C F Jilka J M Hood E E and Howard J A | 2003 | Vaccine2003，21，： | 1 |
| 6 | OLED/CMOS combo opens a new world of microdisplay 显示文摘 | Jones S K Howard W E | 2001 | Laser Focus World2001，37，12： | 1 |
| 7 | Conductive polymer composite materials and their utility in electromagnetic shielding applications显示文摘 | Fox R T Wani V Howard K E | 2008 | Journal of Applied Polymer Science2008，107，4： | 1 |
| 8 | The relation- ship of cataract and cataract extraction to age-related macular degeneration : The Beaver Dam Eye Study 显示文摘 | Klein B E Howard K P Lee K E | 2012 | Ophthalmology2012，119，8： | 1 |
| 9 | The impact of diabetes on left ventricular filling pattern in normotensive and hypertensive adults: the strong heart study显示文摘 | Jennifer E Liu Vittorio Palmieri Mary J Roman Jonanthan N Bella Richard Fabsitz Barbara V Howard Thomas K Welty Elisa T Lee Richard B Devereux | 2001 | Journal of the American College of Cardiology2001，，7： | 1 |
| 10 | 应用2017年美国心脏病学会/美国心脏协会血压指南预防潜在的心血管病事件显示文摘该研究在美国高血压成人患者比较血压达到2017年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)指南推荐的血压目标与(1)当前血压水平,(2)达到2003年高血压预防、检测、评估和治疗全国联合委员会(the joint national committee on prevention,detection,evaluatioyl and treatment of highblood pressure,JNC)第七次报告(JNC7)目标;以及(3)达到2014年JNC第8次报告(JNCS)血压目标时可预防的心血管事件数和治疗相关严重不良事件的发生次数。 | Bress AP Colantonio LD Cooper R Kramer H Booth JN Odden MC Bibbins-Domingo K Shimbo D Whelton PK Levitan EB Howard G Bellows BK Kleindorfer D Safford MM Muntner P Andrew E 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 1 |
| 11 | Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses显示文摘 | Zumey J Howard K E Sherry B | 2007 | J Virol2007，81，13： | 1 |
| 12 | Criteria for high--level expression of a fungal laecase gene in transgenic maize显示文摘 | Hood E E Bailey M R Beifuss K Magallanes--Lundback M Horn M E Callaway E Drees C Delaney D E Clough R and Howard J A | 2003 | Plant Biotechnology Journal2003，1，： | 1 |
| 13 | Cell sorting but not serum starvation is effective for SV40 human corneal epithelial cell cycle synchronization 显示文摘 | Liliensiek S J Schell K Howard E | 2006 | Experimental Eye Research2006，83，1： | 1 |
| 14 | Serum lipids and proliferative diabetic retinopathy and macular edema in persons with long-term type 1 diabetes mellitus: the wisconsin epidemiologic study of diabetic retinopathy显示文摘 | Klein B E Myers C E Howard K P | 2014 | Jama Ophthal- mology2014，133，5： | 1 |
| 15 | Transcription of testicular angiotensin converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene 显示文摘 | Howard T E Shai S Y Langford K G | 1990 | Mol Cell Biol1990，，： | 1 |
| 16 | Identification of multiple constitutive and inducible hepatic cytochrome CYP enzymes in market weight swine 显示文摘 | MYERS M J FARRELL D E HOWARD K D | 2001 | Drug Metab Dispos2001，29，3： | 1 |
| 17 | Selecting the donor liver: risk factors for poor function after orthotopic liver transplantation显示文摘 | STRASBERG S M HOWARD T K MOLMENTI E P | 1994 | Hepatology1994，20，41： | 1 |
| 18 | EIT and LASCO Observation of the Initiation of a Coronal Mass Ejection显示文摘 | Dere K P Brueckner G E Howard R A | 1997 | Solar Phys1997，175，： | 1 |
| 19 | The CI- FLOW Project:A sytem for total water level prediction from the summit to the sea显示文摘 | VAN C S KELLEHER K E HOWARD K | 2011 | Bulletin of the American Meteoro- logical Society2011，92，11： | 1 |
| 20 | Determination of the analgesic dose–response relationship for epidural fentanyl and sufentanil with bupivacaine 0.125% in laboring patients显示文摘 | Norman L Herman Kevin L Sheu Tama K Van Decar Joyce D Rubin Farida Gadalla Howard D Koff John E Reynolds | 1998 | Journal of Clinical Anesthesia1998，，8： | 1 |
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