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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Bioretention column studies of phosphorus removal from urban storm water runoff显示文摘 | Hsieh C H Davis A P Needleman B A | 2007 | Water Environ Res2007，79，2： | 1 |
| 3 | Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways 显示文摘 | Chen P N Hsieh Y S Chiou H L | 2005 | Chem Biol Interact2005，156，： | 1 |
| 4 | Multiple-event study of bioretention for treatment of urban storm water runoff显示文摘 | Hsieh C H Davis A P | 2005 | Water Sci Technol2005，51，34： | 1 |
| 5 | The global attractor of a dissipative nonlinear evolution system显示文摘 | Jian H Y Wang X P Hsieh D Y | 1999 | J Math Anal Appl1999，238，： | 1 |
| 6 | Heterology expression of the Arabidopsis…C-Repeat/dehydration response element binding factor 1 gene confers elevated tolerance to chilling and oxidative stressesin transgenic tomato显示文摘 | Hsieh T H Lee J T Yang P T | 2002 | Plant Physiology2002，129，： | 1 |
| 7 | Heterology expression of the arabidopsis C-repeat/dehydration response element binding factor 1 gene confers elevated tolerance to chilling and oxidative stresses in transgenic tomato显示文摘 | Hsieh T H Lee J T Yang P T | 2002 | Plant Physi- ol2002，129，： | 1 |
| 8 | Mutifunctional arc ion plated TiO2 photocatalytic coatings with improved wear and corrosion protection显示文摘 | CHUNG C J HSIEH P Y HSIAO C H | 2009 | Surface Coatings Technol2009，203，12： | 1 |
| 9 | Prediction-based reversible data hiding显示文摘 | Tseng H W Hsieh C P | 2009 | Information Sciences2009，179，： | 1 |
| 10 | Prediction-based reversible data hid?ing显示文摘 | Tseng H W Hsieh C P | 2009 | Information Sciences2009，179，14： | 1 |
| 11 | Top-emitting organic light emitting devices using surface-modified Ag anode显示文摘 | Chen C W Hsieh P Y Chiang H H | 2003 | Applied Physics Letters2003，83，25： | 1 |
| 12 | The influence of implicit theories and message frame on the persuasiveness of disease prevention and detection advocacies显示文摘 | Mathur P Jain S P Hsieh M H | 2013 | Organizational Behavior and Human Decision Processes2013，122，2： | 1 |
| 13 | Improving Mobile IP Handoff by Recorded Neighbor Information显示文摘 | Chuang P J Hsieh C H Lin C S | 2012 | Journal of the Chinese Institute of Engineers2012，35，5： | 1 |
| 14 | Handwashing Program for the Prevention of Nosocomial Infection in a Neonatal Intensive Care Unit 显示文摘 | Won S P Chou H C Hsieh W S | 2004 | Infect Control Hosp Epidemiol2004，25，9： | 1 |
| 15 | Heterology expression of the Arabidopsis C-repeat/dehydration-responsive element binding factor 1 gene confers elevated tolerance to chilling and oxidative stresses in transgenic tomato显示文摘 | Hsieh T H Lee J T Yang P T | 2002 | Plant Physiology2002，129，： | 1 |
| 16 | Mutagenicity of aflatoxins related to their metabolism and carcinogenic potentia 显示文摘 | Wong J J Hsieh D P H | 1976 | Proc Natl Acad Sci USA1976，73，： | 1 |
| 17 | C/D class MADS box genes from two monocots,orchid (Oncidium Cower Ramsey) and lily (Lilium lon- giflorum), exhibit different effects on floral transition and formation in Arahi- dopsis thaliana显示文摘 | Hsu H F Hsieh W P Chen M K | 2010 | Plant and Ceil Physiology2010，51，6： | 1 |
| 18 | Attribution and self-efficacy and their interrelationship in the Korean EFL context显示文摘 | Hsieh P P Kang H | | 0，，03： | 1 |
| 19 | Sharing secrets in stego images with authentication 显示文摘 | Chang C C Hsieh Y P Lin C H | 2008 | Pattern Recognition2008，41，10： | 1 |
| 20 | Diffusion methods for the determination of reduced inorganic sulfur species in sediments 显示文摘 | Hsieh Y P Yang C H | 1989 | Limnol Oceanogr1989，34，： | 1 |
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