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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Chaosin in mechanism with time delay under parametric and external显示文摘 | Plaut R H Hsieh J C | 1987 | Journal of Sound and Vibration1987，11，4： | 1 |
| 3 | Constructing en- dophenotypes of complex diseases using non-negative matrix factorization and adjusted rand index显示文摘 | Wang H M Hsiao C L Hsieh A R | 2012 | PLoS One2012，7，40： | 1 |
| 4 | Application of electrolyzed oxidizing water on the reduction of bacterial contamination for seafood显示文摘 | HUANG Y R HSIEH H S LIN S Y | 2006 | Food Control2006，17，： | 1 |
| 5 | A novel mutation in the mitochondrial 16S rRNA gene in a patient with MELAS syndrome,diabetes mellitus,hyperthyroidism and cardiomyopathy显示文摘 | Hsieh R H Li J Y Pang C Y | 2001 | J Biomed Sci2001，8，： | 1 |
| 6 | Serum intedeukin-6 and tumor necrosis factor-Alpha concentrations in children with mycoplasma pneumonia显示文摘 | HSIEH C C TANG R B TSAI C H | 2001 | J Micr-obiol Immunol Infect2001，34，2： | 1 |
| 7 | Development of a monoclonal antibody specific to cooked mammalian meats显示文摘 | Hsieh Y H Sheu S C Bridgman R C | 1998 | J Food Prot1998，61，4： | 1 |
| 8 | Monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for sensitive detection of prohibited ruminant proteins in feedstuffs显示文摘 | Chen F C Hsieh Y H Bridgman R C | 2004 | J Food Prot2004，67，3： | 1 |
| 9 | Flat-top interleavers using two Gires-Tournois etalons as phase-dispersion mirrors in a Michelson interferometer 显示文摘 | HSIEH C H WANG R B WEN Z Q J | 2003 | IEEE Photonics Technol Lett2003，15，2： | 1 |
| 10 | Double-yield-surface model I: theory显示文摘 | HSIEH H S KAVAZANJIAN JR E BORJA R I | 1990 | Journal of Geotechnical Engineering ASCE1990，116，9： | 1 |
| 11 | Tumor microsatellite in- stability and clinical outcome in young patients with col- oreetal cancer显示文摘 | Gryfe R Kim H Hsieh ET | 2000 | N Engl J Med2000，342，2： | 1 |
| 12 | Multiple rearrangements of mitochondrial DNA and defective oxidative phosphorylation gene expression in unfertilized human oocytes 显示文摘 | HSIEH R TSAI N AU H | 2001 | Fertil Steril2001，76，1： | 1 |
| 13 | Application of electrolyzed oxidizing water on the reduetinn of bacterial contamination for seafood 显示文摘 | Huang Y R Hsieh H S Lin S Y | 2006 | Food Control2006，17，： | 1 |
| 14 | Chaosin in mechanism with time delay under parametric and external显示文摘 | R H Plaut J C Hsieh | 1987 | Journal of Sound and Vibration1987，114，： | 1 |
| 15 | Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells显示文摘 | Chen Y Y Wu Y C Chia Y Chang F R Hsu H K Hsieh Y C Chen C C Yuan S S | 2009 | Cancer Letters2009，286，2： | 1 |
| 16 | Blind maximum-likelihood carrier-frequency-offset estimation for interleaved OFDMA uplink systems显示文摘 | Hsieh H T and Wu W R | | 0，，01： | 1 |
| 17 | Microst ructure and pitting corrosion in simulated heat affected zones of duplex stainless steels 显示文摘 | Liou H Y Hsieh R I Tsai W T | 2002 | Mater Chem Phys2002，74，1： | 1 |
| 18 | Development of a monoclonal antibody specific to cooked mammalian meats 显示文摘 | Hsieh Y H P Sheu S C Bridgman R C | 1998 | J Food Prot1998，61，4： | 1 |
| 19 | Application of electrolyzed oxidizing water on the reduction of bacterial contamination for seafood 显示文摘 | HUANG Y R HSIEH H S LIN S Y | 2006 | Food Control2006，17，12： | 1 |
| 20 | Visible light activity of Pt/N-TiO2 towards enhanced H2 production ~rom water split- ting显示文摘 | Wu R J Hsieh Y C Hung H C | 2014 | Journal of the Chinese Chemical Society2014，61，49： | 1 |
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