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318篇 您的检索式:作者名="HUGHES C S"
    题名 作者 年代 出处 被引量
1皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 2016国际脑血管病杂志2016,24,6:18
2饮水微量元素与老年人群认知能力关系研究显示文摘在中国山东与河南两省农村研究了饮水中微量元素与老年人群认知能力 (CognitiveFunction)之间的关系。采用中国国标方法分析了饮水中氟、钙、硒、铝、铁、锌、镉、铅、砷微量元素和pH值 ;用老年性痴呆症 (Dementia)调查表 ,进行了≥ 6 5岁老年暴露人群认知能力的测定。调整年龄、性别和文化水平后 ,对微量元素与老年认知能力之间的关系进行直线模型、二次方模型和联合作用模型的统计分析 ,评价饮水中每种微量元素浓度对老年认知能力的影响。结果表明 ,单因素分析时发现几种微量元素对老年认知能力有明显作用。然而 ,在调整其它元素水平后 ,其中一些元素的作用消失。饮水中钙浓度对老年认知能力呈现一作用曲线 ,即随着饮水钙水平升高而认知能力增加 ;到某一点高峰后 ,又随钙水平增加而认知能力降低。而锌与镉之间存在一种相互作用 ,即在低饮水镉水平时 ,锌浓度与认知能力呈正相关 ,但在高饮水镉水平时 。梁超轲 吉荣娣 曹静祥 姜玉亭 余波 马凤 吴云鹏 应波 张妍 孙淑庄 Li Yiming Christine L Emsley Gao Sujuan Kathleen S Hall Hugh C Hendrie 2003卫生研究2003,32,5:12
3Acute and subacute effects of naturally occurring estrogens on luteinizing hormone secretion in the ovariectomised rat: part 2 显示文摘Hughes C L Chakinala M M Reece S G 1991Reprod Toxicol1991,5,:1
4Renal artery perfusion modifies ischemia/reperfusion injury显示文摘HUGHES J D MATTAR S G CHEN C 1996J Surg Res1996,60,2:1
5Finite element analysis of bone stress and strain around a distal osseointegrated implant for prosthetic limb attachment显示文摘Xu W Crocombe A D Hughes S C 2000Proc Inst Mech Eng2000,214,6:1
6Demonstration of protontransfer reaction time-of-flight mass spectrometry for real-time analysis of trace volatile organic compounds显示文摘Blake R S Whyte C hughes C 2004Analytical Chemistry2004,76,13:1
7Acomparison of baseline and induced DNA damage in human spermatozoa from fertile and infertile men, using a modified comet assay显示文摘Hughes C M Lewis S E McKelvey-Martin V J 1996Mol Hum Reprod1996,2,:1
8Quinazolinones as gamma-secretase modulators 显示文摘FISCHER C SHAH S HUGHES B L 2011Bioorg Med Chem Lett2011,21,2:1
9Analytical Chemistry显示文摘Blake R S Whyte C hughes C 200476(13):38412004,76,13:1
10Invited review--survey of value - focused thinking: Applications, research developments and areas for fu- ture research显示文摘PARNELL G S HUGHES D W BURK R C etal 2013Journal of Multi-Criteria Decision Analysis2013,20,12:1
11Estrogenic soybean isoflavones and chronic disease-risks and benefits显示文摘CLARKSON T B ANTHONY M S HUGHES C L 1995Trends Endocrinol Metab1995,6,1:1
12IL-4 and IL-13 activate the JAK2 tyrosine kinase and Stat6 in cultured human vascular endothelial cells through a common pathway that does not involve the gamma c chain显示文摘 Hughes C C Pober J S 1996J Clin Invest1996,98,3:1
13Eosinophilia , interleukin-5, and tumour necrosis factor-alpha inasthmatic children显示文摘Hughes J M Rimmer S J Salome C M 2001Allergy2001,56,5:1
14Elevated enzyme activities in soils under the invasive nitrogen-fixing tree falcataria moluccana显示文摘Allison S D Nielsen C Hughes R F 2006Soil Biology & Biochemistry2006,38,7:1
15Mutagenicity of ni troaromatic degradation compounds 显示文摘Padda R S Wang C Hughes J B 2003Environmental Tox icology & Chemistry2003,22,:1
16Soy isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys显示文摘Anthony M S Clarkson T B Hughes C L J Morgan T M Burke GL 1996J Nutr1996,126,1:1
17Worldwide survey on the methods,efficacy,and safety of catheter ablation for human arial fibrillation显示文摘Riccardo C Hugh C Chen S A 2005Circulation2005,111,9:1
18Effects of perches on trabecular bone volume in laying hens显示文摘Wilson S B O Hughes M C Appleby 1993Res Vet Sci1993,54,:1
19Minimally disruptive decompression and transforaminal lumbar interbody fusion显示文摘Ozgur B M Hughes S A Baird L C 2006Spine J2006,6,1:1
20Cutting edge: progesterone regu- lates IFN-alpha production by plasmacytoid dendritic cells 显示文摘Hughes GC Thomas S Li C 2008J Immunol2008,180,4:1
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