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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Carotid intima-media thickness:an index for subclinical atherosclerosis in type 1 diabetes显示文摘 | Abdelghaffar S EI Amir M EI Hadidi A | 2006 | Trop Pediatr2006，52，1： | 1 |
| 3 | Molecular modeling and spectroscopic studies on the interaction of the chiral drug venlafaxine hydrochloride with bovine serum albumin显示文摘 | SHAHABADI N HADIDI S | 2014 | Spectrochimica Acta Part A2014，122，： | 1 |
| 4 | Medical complications of re-nal transpantation显示文摘 | Fahdi L Hadidy S | 1999 | Transplantation Proceedings1999，31，8： | 1 |
| 5 | Antisense deoxyoligonucleotides or antibodies to murine MD-1 inhibit rejection of allogeneic and xenogeneic skin grafts in C3H mice 显示文摘 | Hadidi S Chen Z Phillips J | 2002 | Transplantation2002，73，11： | 1 |
| 6 | Carotid intimamedia thickness: an index for subclinical atherosclerosis in type 1 diabetes显示文摘 | Abdelghaffar S El Amir M El Hadidi A | 2006 | J Trop Pediatr2006，52，1： | 1 |
| 7 | Sensitive detection of potato spindle tuber viroid using RT-PCR and identification of variant naturally infecting pepino plants显示文摘 | Shanloul A M Hadidi A Zhu S F | 1997 | Can J Plant Phathol1997，19，： | 1 |
| 8 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 9 | Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men显示文摘 | E1 Hadidy el HM Ghonaim M E1 Gawad S | 2011 | BMC Endocr Disord2011，1115，： | 1 |
| 10 | Nucleotide sequence and secondary structure of pome fruit viroids from dapple apple diseased apples,pear rusty skin diseased pears and apple scar skin symptomless pears显示文摘 | ZHU S F HADIDI A YANG X HAMMOND R W HANSEN A J | 1995 | Acta Horticulturae1995，386，： | 1 |
| 11 | Evaluation of the reaction rate constants for chlorinated ethylene and ethane decomposition in attachment-dominated atmospheric pressure dry-air plasmas显示文摘 | VITALE S A HADIDI K COHN D R | 1997 | Physics Letters A1997，232，6： | 1 |
| 12 | IC-PCR amplification of apple stem grooving virus isolates and comparison of polymerase and coat protein gene sequences 显示文摘 | CROSSLEY S J JACOBI V ADAMS A N HADIDI A | 1998 | Acta Hortieulturae1998，472，： | 1 |
| 13 | Performance evaluation and benchmarking for main- tenance decision making units at petrochemical corpo- ration using a DEA model 显示文摘 | ASSAF S A HADIDI L A HASSANAIN M A | 2015 | International Journal of Advanced Manufacturing Technology2015，76，9： | 1 |
| 14 | Fractures of the metacarpals: treatment by AO screw and plate fixation显示文摘 | Ford DJ El - Hadidi S Lunn PG | 1987 | J Hand Surg( Br)1987，12，： | 1 |
| 15 | Linear recursive state estimators under uncertain observations显示文摘 | HADIDI M SCHWARTZ S | 1979 | IEEE Trans Auto Cont1979，24，： | 1 |
| 16 | Detection of potato leafroll andstraw berry mild yellow-edge luteo virus by RT-PCR 显示文摘 | Hadidi A Montasser M S Levy L | 1993 | PlantDisease1993，77，6： | 1 |
| 17 | Stability of morphine and buprenorphine in whole blood 显示文摘 | Hadidi K A Oliver J S | 1998 | Int J Legal Med1998，111，3： | 1 |
| 18 | Linear recursive state estimators under uncertain observations显示文摘 | Hadidi M T Schwartz S C | 1979 | IEEE Transactions on Automatic Control1979，24，6： | 1 |
| 19 | Accuracy of single versus combined use of ultrasonography or computed tomo- graphy in the localization of parathyroid adenoma显示文摘 | Younes N A Hadidi A M Mahafzah W S | 2008 | Saudi Med J2008，29，2： | 1 |
| 20 | Remodeling after femoral shaft fractures in children treated by the modified blount method显示文摘 | Malkawi H Shannak A Hadidi S | 1986 | J Pediatr Orthop1986，6，4： | 1 |
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