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| 1 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, protects pancreas against acute cerulein-induced pancreatitis显示文摘ABM: To determine the effect of pioglitazone, a specific peroxisome proliferator-activated receptor-γ(PPARγ) ligand, on the development of acute pancreatitis (AP) and on the expression of heat shock protein 70 (HSP70) in the pancreas. METHODS: AP was induced in rats by subcutaneous infusion of cerulein for 5 h. Pancreatic blood flow was measured by laser Doppler flowmetry. Plasma lipase activity, interleukin-1β (IL-1β) and IL-10 were determined, Pancreatic weight and histology were evaluated and pancreatic DNA synthesis and blood flow as well as pancreatic mRNA for IL-1β and HSP70 were assessed in rats treated with pioglitazone alone or in combination with cerulein. RESULTS: Pioglitazone administered (10-100 mg/kg i.g.) 30 min before cerulein, attenuated dose-dependently the pancreatic tissue damage in cerulein-induced pancreatitis (CIP) as demonstrated by the improvement of pancreatic histology, reduction in plasma lipase activity, plasma concentration of pro-inflammatory IL-1β and its gene expression in the pancreas and attenuation of the pancreatitis-evoked fall in pancreatic blood flow. CIP increased pancreatic HSP70 mRNA and protein expression in the pancreas and this effect was enhanced by pioglitazone treatment. CONCLUSION: Pioglitazone attenuates CIP and the beneficial effect of this pioglitazone is multifactorial probably due to its anti-inflammatory activities, to the suppression of IL-1β and to the over-expression of HSP70. PPARγ ligands could represent a new therapeutic option in the treatment of AP. | Peter C Konturek Artur Dembinski Zygmunt Warzecha Grzegorz Burnat Piotr Ceranowicz Eckhart G Hahn Marcin Dembinski Romana Tomaszewska Stanislaw J Konturek | 2005 | World Journal of Gastroenterology2005，11，40： | 7 |
| 2 | Flavivirus Genome Organization, Expression, and Replication显示文摘 | T J Chambers C S Hahn R Galler C M Rice | 1990 | Annual Review of Microbiology1990，，： | 2 |
| 3 | Flavivirus Genome Organization, Expression, and Replication显示文摘 | T J Chambers C S Hahn R Galler C M Rice | 1990 | Annual Review of Microbiology1990，，： | 2 |
| 4 | A study on comparison of optimization performances between immune algorithm and other heuristic algorithms 显示文摘 | Sung C J Jang Hyun Kyo Hahn Song Yop | 1998 | IEEE Trans on Magnetics1998，34，5： | 2 |
| 5 | Emergence of new project teams from open source software developer networks: Impact of prior collaboration ties 显示文摘 | Hahn J Moon J Y Zhang C | 2008 | Information Systems Research2008，19，3： | 1 |
| 6 | Flavivirus genome organization expression and replication显示文摘 | Chambers T J Hahn C S Galler R | 1990 | Annu Rev Microbiol1990，44，： | 1 |
| 7 | A fast algo- rithm for Euler's elastic method using augmented Lagrangian method显示文摘 | TAI X C HAHN J CHUNG G J | 2010 | SIAM J Imaging Sci2010，4，5： | 1 |
| 8 | Field trial to evaluate immunogenicity of a glycoprotein I (gE) - deleted pseudorabies virus vaccine after its administration in the presence ofmaternal antibodies显示文摘 | Weigel R M Lehman J R Herr L Hahn E C | 1995 | Am J Vet Res1995，56，9： | 1 |
| 9 | Expression of cyclin D1 is correlated with poor prognosis in patients with areca quid chewing-related oral squamous cell carcinomas in Taiwan显示文摘 | KUO M Y P LIN C Y HAHN L J | 1999 | J Oral Pathol Med1999，28，4： | 1 |
| 10 | Cytokine induction by streptococ- cus mutans and pulpal pathagenesis显示文摘 | Hahn C L Best A M Tew J G | 2000 | Infect Immun2000，68，12： | 1 |
| 11 | Temperature rise prediction of EHV GIS bus bar by coupled magnetothermal finite element method显示文摘 | Kim J K Hahn S C Park K Y | 2005 | IEEE Transactions on Magnetics2005，41，5： | 1 |
| 12 | Just-in-time production and purchasing 显示文摘 | Hahn C K Pinto P A Braggd J | 1983 | Journal of Purchasing Materials Management1983，，： | 1 |
| 13 | Flavivirus genome organ-ization,expression and replication显示文摘 | Chambers T J Hahn C S Galler R | 1990 | Annu Rev Microbio1990，44，： | 1 |
| 14 | Immunoreactivity of CD99 in stomach caneer显示文摘 | Jung K C Park W S Bae Y M Hahn J H Hahn K Lee H | 2002 | J Korean Med Sci2002，17，： | 1 |
| 15 | Just-in-time Production and Purchasing 显示文摘 | Pinto P A Bragg D J | 1983 | Journal of Purchasing and Materials Management1983，19，3： | 1 |
| 16 | Six-month versus 12-month dual antiplatelet therapy after implantation of drug-eluting stentsclinical perspective the efficacy of xience/ promus versus cypher to reduce late loss after stenting (EXCELLENT) randomized, muhicenter study显示文摘 | GWON H C HAHN J Y PARK K W | 2012 | Circulation2012，125，3： | 1 |
| 17 | Kinetics and mechanism of the oxidation of sulfur(IV) by ozone in aqueous solutions显示文摘 | BOTHA C F HAHN J PIENAAR J J | 1994 | Atmospheric Environment1994，28，20： | 1 |
| 18 | Inoculum size and auxinconcentration influence the growth of adventitious roots and accumulation of ginsenosides in suspension cultures of ginseng(Panax ginseng CA Meyer)显示文摘 | JEONG C S MURTHY H N HAHN E J | 2009 | Acta Physiol Plant2009，31，1： | 1 |
| 19 | T/P23,24,911 and 92:new grades for advanced coal-fired power plants-properties and experience显示文摘 | VAILLANT J C VANDENBERGHE B HAHN B | 2008 | Pressure Vessels and Piping2008，85，12： | 1 |
| 20 | Effects of oxygen, carbon dioxide and ethylene on growth and bioactive compound production in bioreactor culture of ginseng adventitious roots 显示文摘 | Jeong C S Chakrabarty D Hahn E J | 2006 | Biochem Eng J2006，27，： | 1 |
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