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| 1 | Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents显示文摘The Keap1–Nrf2–ARE pathway is an important antioxidant defense mechanism that protects cells from oxidative stress and the Keap1–Nrf2 protein–protein interaction(PPI) has become an important drug target to upregulate the expression of ARE-controlled cytoprotective oxidative stress response enzymes in the development of therapeutic and preventive agents for a number of diseases and conditions. However, most known Nrf2 activators/ARE inducers are indirect inhibitors of Keap1–Nrf2PPI and they are electrophilic species that act by modifying the sulfhydryl groups of Keap1's cysteine residues. The electrophilicity of these indirect inhibitors may cause 'off-target' side effects by reacting with cysteine residues of other important cellular proteins. Efforts have recently been focused on the development of direct inhibitors of Keap1–Nrf2 PPI. This article reviews these recent research efforts including the development of high throughput screening assays, the discovery of peptide and small molecule direct inhibitors, and the biophysical characterization of the binding of these inhibitors to the target Keap1 Kelch domain protein. These non-covalent direct inhibitors of Keap1–Nrf2 PPI could potentially be developed into effective therapeutic or preventive agents for a variety of diseases and conditions. | Dhulfiqar Ali Abed Melanie Goldstein Haifa Albanyan Huijuan Jin Longqin Hu | 2015 | Acta Pharmaceutica Sinica B2015，5，4： | 46 |
| 2 | Diversity of metabolite accumulation patterns in inner and outer seed coats of pomegranate:exploring their relationship with genetic mechanisms of seed coat development显示文摘The expanded outer seed coat and the rigid inner seed coat of pomegranate seeds,both affect the sensory qualities of the fruit and its acceptability to consumers.Pomegranate seeds are also an appealing model for the study of seed coat differentiation and development.We conducted nontarget metabolic profiling to detect metabolites that contribute to the morphological differentiation of the seed coats along with transcriptomic profiling to unravel the genetic mechanisms underlying this process.Comparisons of metabolites in the lignin biosynthetic pathway accumulating in seed coat layers at different developmental stages revealed that monolignols,including coniferyl alcohol and sinapyl alcohol,greatly accumulated in inner seed coats and monolignol glucosides greatly accumulated in outer seed coats.Strong expression of genes involved in monolignol biosynthesis and transport might explain the spatial patterns of biosynthesis and accumulation of these metabolites.Hemicellulose constituents and flavonoids in particular accumulated in the inner seed coat,and candidate genes that might be involved in their accumulation were also identified.Genes encoding transcription factors regulating monolignol,cellulose,and hemicellulose metabolism were chosen by coexpression analysis.These results provide insights into metabolic factors influencing seed coat differentiation and a reference for studying seed coat developmental biology and pomegranate genetic improvement. | Gaihua Qin Chunyan Liu Jiyu Li Yongjie Qi Zhenghui Gao Xiaoling Zhang Xingkai Yi Haifa Pan Ray Ming Yiliu Xu | 2020 | Horticulture Research2020，7，1： | 4 |
| 3 | Geophysical and Production Data History Matching Based on Ensemble Smoother with Multiple Data Assimilation显示文摘The Ensemble Kalman Filter(EnKF),as the most popular sequential data assimilation algorithm for history matching,has the intrinsic problem of high computational cost and the potential inconsistency of state variables updated at each loop of data assimilation and its corresponding reservoir simulated result.This problem forbids the reservoir engineers to make the best use of the 4D seismic data,which provides valuable information about the fluid change inside the reservoir.Moreover,only matching the production data in the past is not enough to accurately forecast the future,and the development plan based on the false forecast is very likely to be suboptimal.To solve this problem,we developed a workflow for geophysical and production data history matching by modifying ensemble smoother with multiple data assimilation(ESMDA).In this work,we derived the mathematical expressions of ESMDA and discussed its scope of applications.The geophysical data we used is P-wave impedance,which is typically included in a basic seismic interpretation,and it directly reflects the saturation change in the reservoir.Full resolution of the seismic data is not necessary,we subsampled the P-wave impedance data to further reduce the computational cost.With our case studies on a benchmark synthetic reservoir model,we also showed the supremacy of matching both geophysical and production data,than the traditional reservoir history matching merely on the production data:the overall percentage error of the observed data is halved,and the variances of the updated forecasts are reduced by two orders of the magnitude. | Zelong Wang Xiangui Liu Haifa Tang Zhikai Lv Qunming Liu | 2020 | Computer Modeling in Engineering & Sciences2020，，5： | 2 |
| 4 | Sliced orthogonal nonlinear generalized decomposition based fringe-adjusted joint transform correlation 显示文摘 | Qu Wang Haifa Zhao Shutian Liu | 2004 | Optik2004，115，9： | 1 |
| 5 | The role of biochemicalmarkers of bone turnover in the diagnosis of osteoporosis and predicting fracture risk 显示文摘 | Mohamed Y Haifa H Datel O | 2014 | Tunis Med2014，92，5： | 1 |
| 6 | An mRNA vaccine elicits STING-dependent antitumor immune responses显示文摘Lipid-formulated RNA vaccines have been widely used for disease prevention and treatment,yet their mechanism of action and individual components contributing to such actions remain to be delineated.Here,we show that a therapeutic cancer vaccine composed of a protamine/mRNA core and a lipid shell is highly potent in promoting cytotoxic CD8+T cell responses and mediating anti-tumor immunity.Mechanistically,both the mRNA core and lipid shell are needed to fully stimulate the expression of type I interferons and inflammatory cytokines in dendritic cells.Stimulation of interferon-βexpression is exclusively dependent on STING,and antitumor activity from the mRNA vaccine is significantly compromised in mice with a defective Sting gene.Thus,the mRNA vaccine elicits STING-dependent antitumor immunity. | Zhe Chen Chaoyang Meng Junhua Mai Yongbin Liu Hangwen Li Haifa Shen | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 1 |
| 7 | Ground fault location ona transmission line using high-frequency transient voltages 显示文摘 | REDY M HAIFA A M CHARLES Q s | 2011 | IEEE Transactions on Power Delivery2011，26，2： | 1 |
| 8 | A discrete fractional random transform 显示文摘 | Liu Zhengjun Zhao Haifa Liu Shutian | 2005 | Opt Commun2005，255，46： | 1 |
| 9 | Image eneryption based on pure intensity random coding and digital holography technique显示文摘 | Banghe Zhu Haifa Zhao Shutian Liu | 2003 | Optik2003，114，2： | 1 |
| 10 | The Binding Site for TRAF2 and TRAF3 but Not for TRAF6 Is Essential for CD40-Mediated Immunoglobulin Class Switching显示文摘 | Haifa H Jabara Dhafer Laouini | 2002 | Immunity2002，17，： | 1 |
| 11 | Generation of Hollow Gaussian Beams by Spatial Filtering显示文摘 | Liu Zhengjun Zhao Haifa Liu Jianlong | 2007 | OPTICS LET- TERS2007，32，15： | 1 |
| 12 | The Amplatzer duct occluder:experience in 209 patients显示文摘 | BILKIS A A ALWI M HAIFA S | 2001 | J Am Coll Cardiol2001，37，1： | 1 |
| 13 | Video-assisted thoracoscopic surgery in the treatment of chest trauma:long-term benefit显示文摘 | HAIFA ISRAE DEPARTMENT OF GENERAL THORACIC SURGERY RAMBAM MEDICAL CENTERL | 2007 | The Annals of Thoracic Surgery2007，83，2： | 1 |
| 14 | Increasing Lump Ores Proportion in Blast Furnace Based on the High- Temperature Interactivity of Iron Bearing Materials显示文摘 | Wu Shengli Han Hongliang Xu Haifa | 2010 | ISIJ International2010，50，5： | 1 |
| 15 | Evaluation of lump ores for use in modern blast furnaces as part of mixed burden practice显示文摘 | WU Shengli XU Haifa TIAN Yunqing | 2009 | Ironmaking & Steelrnaking2009，36，1： | 1 |
| 16 | Increasing lump ores proportion in blast furnace based on the high-temperature interactivity of iron beating materials显示文摘 | WU Shengli HAN Hongliang XU Haifa | 2010 | ISIJ international2010，50，5： | 1 |
| 17 | Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients : Systematic review and meta-analysis of prospective cohort studies 显示文摘 | Haifa M Jos6 MO Ben S | 2014 | European Journal of Cancer2014，50，8： | 1 |
| 18 | Older than 60 years: a study of the East German Hematology and Oncology Study Group ( OSHO ) 显示文摘 | Christoph K Rainer K Haifa KA | 2014 | Blood ( ASH annual meeting abstracts )2014，124，21： | 1 |
| 19 | Changes in the rheo- logical and colloidal properties of paper coating liquids with paper- yellowing inhibition additives 显示文摘 | Haifa E1-Sadi Pierre Carreau Nabil Esmail | 2004 | Journal of Colloid and Interface Science2004，271，： | 1 |
| 20 | 显示文摘 | Xu Qingyu Zai Haifa Wu D | 2009 | Applied Physics Letters2009，95，： | 1 |
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