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| 1 | Factors associated with time to laparoscopic cholecystectomy for acute cholecystitis显示文摘AIM: To determine patient and process of care factors associated with performance of timely laparoscopic cholecystectomy for acute cholecystitis. METHODS: A retrospective medical record review of 88 consecutive patients with acute cholecystitis was conducted. Data collected included demographic data, co-morbidities, symptoms and physical findings at presentation, laboratory and radiological investigations, length of stay, complications, and admission service (medical or surgical). Patients not undergoing cholecystectomy during this hospitalization were excluded from analysis. Hierarchical generalized linear models were constructed to assess the association of pre-operative diagnostic procedures, presenting signs, and admitting service with time to surgery.RESULTS: Seventy cases met inclusion and exclusion criteria, among which 12 were admitted to the medical service and 58 to the surgical service. Mean ± SD time to surgery was 39.3 ± 43 h, with 87% of operations performed within 72 h of hospital arrival. In the adjusted models, longer time to surgery was associated with number of diagnostic studies and endoscopic retrograde cholangio-pancreatography (ERCP, P = 0.01) as well with admission to medical service without adjustment for ERCP (P < 0.05). Patients undergoing both magnetic resonance cholangiopancreatography (MRCP) and computed tomography (CT) scans experienced the longest waits for surgery. Patients admitted to the surgical versus medical service underwent surgery earlier (30.4 ± 34.9 vs 82.7 ± 55.1 h, P < 0.01), had less post-operative complications (12% vs 58%, P < 0.01), and shorter length of stay (4.3 ± 3.4 vs 8.1 ± 5.2 d, P < 0.01).CONCLUSION: Admission to the medical service and performance of numerous diagnostic procedures, ERCP, or MRCP combined with CT scan were associated with longer time to surgery. Expeditious performance of ERCP and MRCP and admission of medically stable patients with suspected cholecystitis to the surgical service to speed up time to surgery should be considered. | Chris N Daniak David Peretz Jonathan M Fine Yun Wang Alan K Meinke William B Hale | 2008 | World Journal of Gastroenterology2008，14，7： | 13 |
| 2 | Phase Space of Retarded Equations with Infinitely Delay 显示文摘 | Hale J K Kato J | 1978 | J Tohoku Marth1978，21，： | 2 |
| 3 | A prospective trial of volumetric intensity-modulated arc therapy vs conventional intensity modulated radiation therapy in advanced head and neck cancer显示文摘AIM: To prospectively compare volumetric intensitymodulated arc therapy(VMAT) and conventional intensity-modulated radiation therapy(IMRT) in coverage of planning target volumes and avoidance of multiple organs at risk(OARs) in patients undergoing definitive chemoradiotherapy for advanced(stage Ⅲ or Ⅳ)squamous cell cancer of the head and neck. METHODS: Computed tomography scans of 20 patients with advanced tumors of the larynx, naso-, oroand hypopharynx were prospectively planned using IMRT(7 field) and VMAT using two arcs. Calculated doses to planning target volume(PTV) and OAR were compared between IMRT and VMAT plans. Dose-volume histograms(DVH) were utilized to obtain calculated doses to PTV and OAR, including parotids, cochlea,spinal cord, brainstem, anterior tongue, pituitary and brachial plexus. DVH's for all structures were compared between IMRT and VMAT plans. In addition the planswere compared for dose conformity and homogeneity. The final treatment plan was chosen by the treating radiation oncologist. RESULTS: VMAT was chosen as the ultimate plan in 18 of 20 patients(90%) because the plans were thought to be otherwise clinically equivalent. The IMRT plan was chosen in 2 of 20 patients because the VMAT plan produced concentric irradiation of the cord which was not overcome even with an avoidance structure. For all patients, VMAT plans had a lower number of average monitor units on average(MU = 542.85) than IMRT plans(MU = 1612.58)(P < 0.001). Using the conformity index(CI), defined as the 95% isodose volume divided by the PTV, the IMRT plan was more conformal with a lower conformity index(CI = 1.61) than the VMAT plan(CI = 2.00)(P = 0.003). Dose homogeneity, as measured by average standard deviation of dose distribution over the PTV, was not different with VMAT(1.45 Gy) or IMRT(1.73 Gy)(P = 0.069). There were no differences in sparing organs at risk.CONCLUSION: In this prospective study, VMAT plans were chosen over IMRT 90% of the time. Compared to IMRT, VMAT plans used only one third of the MUs, had shorter treatment times, and similar sparing of OAR. Overall, VMAT provided similar dose homogeneity but less conformity in PTV irradiation compared to IMRT. This difference in conformity was not clinically significant. | Simon D Fung-Kee-Fung Rachel Hackett Lee Hales Graham Warren Anurag K Singh | 2012 | World Journal of Clinical Oncology2012，3，4： | 2 |
| 4 | Aminotransferases:demonstration of homology and division into evolutionary subgroups显示文摘 | Hale T I and Christen P | 1993 | Eur J Biochem1993，214，： | 1 |
| 5 | Autologous transplantation of CD133 selected hematopoietic progenitor cells for treatment of relapsed acute lymphoblastic leukemia显示文摘 | BARFIELD R C HALE G A BURNETTE K | 2007 | Pediatr Blood Cancer2007，48，3： | 1 |
| 6 | Perturbation of homoclinies and subharmonics in Duffing' s equation 显示文摘 | Hale J K Spezamiglio A | 1985 | Nonlinear Anal : TMA1985，9，： | 1 |
| 7 | Annular honey- comb seals:Test results for leakage and rotordynam- ic coefficients;comparisons to labyrinth and smooth configurations 显示文摘 | CHILDS D ELROD D HALE K | 1989 | Journal of tribology1989，111，2： | 1 |
| 8 | Collision Induced Dissociation of Fe2^+ 显示文摘 | Loh S K Lian L Hales D A | 1988 | J Phys Chem1988，92，： | 1 |
| 9 | 显示文摘 | Morales A R Belfield K D Hales J M | 2006 | Chem Mater2006，18，： | 1 |
| 10 | Manipulation of coupled osmotic flows for stabilization of shale exposed to water- based drilling fluids 显示文摘 | vanOort E Hale A H Mody F K | 1995 | SPE 304991995，，： | 1 |
| 11 | Elemental and mineralogicalchanges in soils due to bioturbation along an earthworm inva-sion chronosequence in Northern Minnesota显示文摘 | Resner K Yoo K Hale C | 2011 | Applied Geo-chemistry2011，26，1： | 1 |
| 12 | Recurrent morphoeic basal carcinoma at the later canthus with orbitocranal invasion显示文摘 | Selva D Hale L Bouskill K | | 0，，02： | 1 |
| 13 | Assessment of Scenic Beauty of the Roadside Vegetation in Northern England显示文摘 | Akbar K F Hale W H G Headley A D | 2003 | Landscape and Urban Planning2003，，63： | 1 |
| 14 | Maf transcriptionally activates the mouse p53 promoter and causes a p53-dependent cell death显示文摘 | MYERS C MAITRA R | 2000 | J Biol Chem2000，275，17： | 1 |
| 15 | Effects of chronic alcohol treatment on the synthesis, sialylation, and disposition of nascent apolipoprotein E by peritoneal macrophages of ratsl-3显示文摘 | GHOSH P HALE E A MAYUR K | 2000 | Am Soci Clin Nutr2000，72，： | 1 |
| 16 | Persistence in infinite-dimensional systems显示文摘 | Hale J K Waltman P | 1989 | SIAM Journal on Math- ematical Analysis1989，20，： | 1 |
| 17 | Effects of varying bulk densities of steam-flaked corn and dietary roughage concentration on in vitro fermentation,performance,carcass quality,and acid-base balance measurements in finishing steers显示文摘 | Hales K E McMeniman J P Leibovich J | 2010 | Journal of Animal Science2010，88，3： | 1 |
| 18 | Phase spacefor retarded equations with infinite delay 显示文摘 | Hale J K Kato J | 1978 | Funkcial Ekvac1978，21，： | 1 |
| 19 | A multifaceted intervention for quality improvement in a network of intensive care units: a cluster ran- domized trial 显示文摘 | Scales DC Dainty K Hales B | 2011 | JAMA2011，305，4： | 1 |
| 20 | Types of Software Evolution and Software Maintenance显示文摘 | Chapin N Hale J E Khan K M | 2001 | Journal of Software Maintenance and Evolution:Research and Practice2001，13，1： | 1 |
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