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| 1 | 低社会经济地位与美国成年人早发冠状动脉粥样硬化性心脏病的关系显示文摘低社会经济地位(socioeconomic status,SES)的个体承担着不成比例的冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)负担。在美国低收入地区,CHD仍然是死亡的主要原因。该研究旨在评估美国低SES个体的过量CHD负担,以及传统风险因素和与低SES相关因素影响所占的比例。 | Hamad R Penko J Kazi DS Coxson P Guzman D Pengxiao C.Wei Mason A Wang EA Goldman L Fiscella K Bibbins-Domingo K 周卫(译) 刘莉(审校) | 2020 | 中华高血压杂志2020，28，7： | 7 |
| 2 | Unexpected alliance between syndecan-1 and innatelike T cells to protect host from autoimmune effects of interleukin-17显示文摘Innate-like T cells, namely natural killer T(NKT) and γδ T cells, play critical roles in linking innate and adaptive immune responses through rapid production of cytokines. Prominent among these cytokines is interleukin-17(IL-17), which is a potent proinflammatory cytokine that plays a critical role in host defense against fungi and extracellular bacteria. However, excessive IL-17-production promotes autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus. IL-17 has also been implicated in regulating body fat, which is highly relevant given rises in obesity and type 2 diabetes. NKT cells, γδ T cells and mucosal-associated invariant T cells(MAIT) are the major sources of IL-17 involved in protection of mucosal surfaces from opportunistic infections and causing autoimmunity when become dysregulated. Given the pathogenic effects of IL-17, efforts have been directed towards understanding mechanisms that guard against IL-17 overproduction. One novel potent mechanism is mediated by the heparan sulfate proteoglycan, syndecan-1(sdc1), which is selectively expressed by IL-17-producing subsets of NKT and γδ T cells. This unexpected role for sdc1 is uncovered by analysis of NKT and γδ T cells in sdc1-deficient mice. In this mini-review, we discuss selective expression of sdc1 by these innate T cells and consequences of its absence on IL-17 homeostasis and pathological implications. | Anil Kumar Jaiswal Mohanraj Sadasivam Abdel Rahim A Hamad | 2018 | World Journal of Diabetes2018，9，12： | 5 |
| 3 | Current understandings of the pathogenesis of type 1 diabetes:Genetics to environment显示文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages. | Adebola Matthew Giwa Rizwan Ahmed Zahra Omidian Neha Majety Kagan Ege Karakus Sarah M Omer Thomas Donner Abdel Rahim A Hamad | 2020 | World Journal of Diabetes2020，11，1： | 2 |
| 4 | Biomechanical Evaluation of Nano-Zirconia Coatings on Ti-6Al-7Nb Implant Screws in Rabbit Tibias显示文摘 | Thekra I. Hamad Abdalbseet A Fatalla Amer Subhi Waheed Zena G. M. Azzawi Ying-guang CAO Ke SONG | 2018 | Current Medical Science2018，38，3： | 2 |
| 5 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 6 | Performance of American Society for Gastrointestinal Endoscopy guidelines for dyspepsia in Saudi population: Prospective observational study显示文摘AIM: To evaluate adherence of primary care physicians(PCPs) to international guidelines when referring patients for upper-gastrointestinal endoscopy(UGE), evaluate the importance of alarm symptoms and the performance of the American Society for Gastrointestinal Endoscopy(ASGE) guidelines in a Saudi population.METHODS: A prospective, observational cross-sectional study on dyspeptic patients undergoing UGE who were referred by PCPs over a 4 mo period. Refer-rals were classified as appropriate or inappropriate according to adherence to ASGE guidelines.RESULTS: Total of 221 dyspeptic patients was enrolled; 161 patients met our inclusion criteria. Mean age was 40.3 years(SD ± 18.1). Females comprised 70.1%. Alarm symptoms included low hemoglobin level(39%), weight loss(18%), vomiting(16%), loss of appetite(16%), difficulty swallowing(3%), and gastrointestinal bleeding(3%). Abnormal endoscopy findings included gastritis(52%), duodenitis(10%), hiatus hernia(7.8%), features suggestive of celiac disease(6.5%), ulcers(3.9%), malignancy(2.6%) and gastroesophageal reflux disease(GERD: 17%). Among patients who underwent UGE, 63% met ASGE guidelines, and 50% had abnormal endoscopic findings. Endoscopy was not indicated in remaining 37% of patients. Among the latter group, endoscopy was normal in 54% of patients. There was no difference in proportion of abnormal endoscopic findings between two groups(P = 0.639).CONCLUSION: Dyspeptic patients had a low prevalence of important endoscopic lesions, and none of the alarm symptoms could significantly predict abnormalendoscopic findings. | Nahla A Azzam Majid A Almadi Hessah Hamad Alamar Lamis Atyah Almalki Rehab Nawaf Alrashedi Rawabi Saleh Alghamdi Waleed Al-hamoudi | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 7 | Solubility studies of paraffin waxes in selected petroleum fractions and toluene 显示文摘 | Beg S A Hamad E Tukur N M | 1993 | Fuel Science & Technology International1993，11，2： | 1 |
| 8 | Conversion to neoral for neurotoxicity after primary adult liver transplantation under tacrolimus显示文摘 | Jain A Brody D Hamad D | 2000 | Transplantation2000，69，1： | 1 |
| 9 | The effect of write-beam wavelength on the grating formation in Eu-doped alkali silicate glasses 显示文摘 | HAMAD A Y WICKSTED J P DIXON G S | 1999 | Opt Mater1999，12，： | 1 |
| 10 | Similarity solution of boundary layer stagnation-point flow to- wards a heated porous stretching sheet saturated with a nanofluid with heat absorption/gen- eration and suction/blowing: a lie group analysis 显示文摘 | Hamad M A A Ferdows M | 2012 | Commun Nonlinear Sci Numer Simu- lat2012，17，1： | 1 |
| 11 | Environmental factors affecting submerged macrophyte communities in regulated waterbodies in Egypt 显示文摘 | Ali M M Hamad A Springuel I V | 1995 | Arch Hydrobiol1995，133，： | 1 |
| 12 | Secretory meningioma显示文摘 | Ejeckam GC Azadeh B Hamad A | | 0，，05： | 1 |
| 13 | Kinetic Insights into the Role of the Solvent in the PolymorpHism of 5-Fluorou-racil from Molecular Dynamics Simulations显示文摘 | Hamad S Moon C Catlow C R A | 2006 | J Phys Chem B2006，110，7： | 1 |
| 14 | Ontology- based approach for measuring semantic similarity显示文摘 | TAIB M A H AOUICHA M B HAMADOU A B | 2014 | Engi- neering Application of Artificial Intelligence2014，，： | 1 |
| 15 | Pilot-plant treatment of olive mill wastewaters by Phanerochaete chrysosporium coupled to anaerobic digestion and ultrafiltration 显示文摘 | Dhouib A Aloui D Hamad N | 2006 | Process Biochemistry2006，41，： | 1 |
| 16 | Structure and stability of small TiO2 nanoparticles显示文摘 | Hamad S Catlow C R A Woodley S M | 2005 | J Phys Chem B2005，109，15： | 1 |
| 17 | The influence of substrate ab- sorbency on coating surface energy显示文摘 | Hamad A T Douglas W B | 2004 | Prog Org Coat2004，4963，： | 1 |
| 18 | A clinical study on the effects of cordless and conventional retraction tech- niques on the gingival and periodontal health显示文摘 | AI Hamad 14 Q Azar W Z Alwaeli H A etal | 2008 | J Clin Peri- odontol2008，，35： | 1 |
| 19 | In selfde- fence: Hexokinase promotes voltagedependent anion channel closure and prevents mitochondria - mediated apoptotie cell death 显示文摘 | Azoulay - Zohar H Israelson A Abu - HamadS | 2004 | Biochem2004，377，： | 1 |
| 20 | Behavior of concrete block masonry under axial compression显示文摘 | DRYSDALE R G HAMAD A A | 1979 | ACI Structural Journal1979，76，3： | 1 |
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